The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals
Open accessAbstract
OBJECTIVE: To estimate the effect of combined antiretroviral therapy (cART) on mortality among HIV-infected individuals after appropriate adjustment for time-varying confounding by indication. DESIGN: A collaboration of 12 prospective cohort studies from Europe and the United States (the HIV-CAUSAL Collaboration) that includes 62 760 HIV-infected, therapy-naive individuals followed for an average of 3.3 years. Inverse probability weighting of marginal structural models was used to adjust for measured confounding by indication. RESULTS: Two thousand and thirty-nine individuals died during the follow-up. The mortality hazard ratio was 0.48 (95% confidence interval 0.41-0.57) for cART initiation versus no initiation. In analyses stratified by CD4 cell count at baseline, the corresponding hazard ratios were 0.29 (0.22-0.37) for less than 100 cells/microl, 0.33 (0.25-0.44) for 100 to less than 200 cells/microl, 0.38 (0.28-0.52) for 200 to less than 350 cells/microl, 0.55 (0.41-0.74) for 350 to less than 500 cells/microl, and 0.77 (0.58-1.01) for 500 cells/microl or more. The estimated hazard ratio varied with years since initiation of cART from 0.57 (0.49-0.67) for less than 1 year since initiation to 0.21 (0.14-0.31) for 5 years or more (P value for trend <0.001). CONCLUSION: We estimated that cART halved the average mortality rate in HIV-infected individuals. The mortality reduction was greater in those with worse prognosis at the start of follow-up.
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Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., Hakim, J. G., Kumwenda, J., Grinsztejn, B., Pilotto, J. H. S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105243 · Cited by 6,873
Morbidity and Aging in HIV-Infected Persons: The Swiss HIV Cohort Study
Hasse, B., Ledergerber, B., Furrer, H., Battegay, M., Hirschel, B., Cavassini, M., Bertisch, B., Bernasconi, E., Weber, R., & Study, T. S. H. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir626 · Cited by 608
Increased Risk of Fragility Fractures among HIV Infected Compared to Uninfected Male Veterans
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Metadata
- Venue
- AIDS
- Published
- 2010-01-02
- Volume
- 24
- Issue
- 1
- Pages
- 123-137
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2172275755
- Cited by
- 462
- References
- 29
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- green
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