The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings
Open accessAbstract
BACKGROUND: It has been suggested that a new strategy for HIV prevention, 'Universal Test and Treat', whereby everyone is tested for HIV once a year and treated immediately with antiretroviral therapy (ART) if they are infected, could 'eliminate' the epidemic and reduce ART costs in the long term. METHODS: We investigated the impact of test-and-treat interventions under a variety of assumptions about the epidemic using a deterministic mathematical model. RESULTS: Our model shows that such an intervention can substantially reduce HIV transmission, but that impact depends crucially on the epidemiological context; in some situations, less aggressive interventions achieve the same results, whereas in others, the proposed intervention reduces HIV by much less. It follows that testing every year and treating immediately is not necessarily the most cost-efficient strategy. We also show that a test-and-treat intervention that does not reach full implementation or coverage could, perversely, increase long-term ART costs. CONCLUSION: Interventions that prevent new infections through ART scale-up may hold substantial promise. However, as plans move forward, careful consideration should be given to the nature of the epidemic and the potential for perverse outcomes.
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Cites
Auvert, B., Taljaard, D., Lagarde, E., Sobngwi-Tambekou, J., Sitta, R., & Puren, A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020298 · Cited by 2,451
Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial.
Bailey, R. C., Moses, S., Parker, C. B., Agot, K., Maclean, I., Krieger, J. N., Williams, C. F., Campbell, R. T., & Ndinya-Achola, J. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60312-2 · Cited by 2,292
Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial.
Gray, R. H., Kigozi, G., Serwadda, D., Makumbi, F., Watya, S., Nalugoda, F., Kiwanuka, N., Moulton, L. H., Chaudhary, M. A., Chen, M. Z., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60313-4 · Cited by 2,226
Granich, R. M., Gilks, C. F., Dye, C., De Cock, K. M., & Williams, B. G. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61697-9 · Cited by 1,988
Attia, S., Egger, M., Müller, M., Zwahlen, M., & Low, N. (2009) · AIDS · doi:10.1097/qad.0b013e32832b7dca · Cited by 1,001
Concurrent partnerships and the spread of HIV
Morris, M., & Kretzschmar, M. (1997) · AIDS · doi:10.1097/00002030-199705000-00012 · Cited by 976
HIV-1 Transmission, by Stage of Infection
Hollingsworth, T. D., Anderson, R. M., & Fraser, C. (2008) · The Journal of Infectious Diseases · doi:10.1086/590501 · Cited by 652
Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe
Gregson, S., Nyamukapa, C. A., Garnett, G. P., Mason, P. R., Zhuwau, T., Caraël, M., Chandiwana, S. K., & Anderson, R. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08780-9 · Cited by 583
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Cited by
Gardner, E. M., McLees, M. P., Steiner, J. F., del Rio, C., & Burman, W. J. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq243 · Cited by 1,893
Combination HIV Prevention: Significance, Challenges, and Opportunities
Kurth, A. E., Celum, C., Baeten, J. M., Vermund, S. H., & Wasserheit, J. N. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0063-3 · Cited by 329
HIV treatment as prevention and HPTN 052
Cohen, M. S., McCauley, M., & Gamble, T. R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834f5cf2 · Cited by 301
Hamlyn, E., Ewings, F. M., Porter, K., Cooper, D. A., Tambussi, G., Schechter, M., Pedersen, C., Okulicz, J. F., McClure, M., Babiker, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043754 · Cited by 71
Metadata
- Authors
- Dodd, P. J., Garnett, G. P., & Hallett, T. B.
- Venue
- AIDS
- Published
- 2010-03-13
- Volume
- 24
- Issue
- 5
- Pages
- 729-735
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2001602693
- Cited by
- 268
- References
- 35
- FWCI
- 24.79
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
