The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
HIV treatment as prevention and HPTN 052
Open accessAbstract
PURPOSE OF REVIEW: This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published. RECENT FINDINGS: A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96%. The logistical challenges in preparing for and conducting such a trial were considerable. SUMMARY: HPTN 052 required many years of preparation, considerable collaboration between National Institute of Health and six pharmaceutical companies, and careful ongoing consideration of a large number of ethical issues. HPTN 052 revealed the magnitude of benefit when using antiretroviral therapy to prevent the transmission of HIV, and served as proof of a concept. The results have proven central to the development of new global HIV-prevention efforts.
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Cites
Prevention of HIV-1 infection with early antiretroviral therapy.
Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., Hakim, J. G., Kumwenda, J., Grinsztejn, B., Pilotto, J. H. S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105243 · Cited by 6,873
Self-citationViral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
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Equipoise and the Ethics of Clinical Research
Freedman, B. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707163170304 · Cited by 2,339
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Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival
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Cited by
Cook, J. A., Burke-Miller, J. K., Steigman, P. J., Schwartz, R. M., Hessol, N. A., Milam, J., Merenstein, D. J., Anastos, K., Golub, E. T., & Cohen, M. H. (2018) · AIDS and Behavior · doi:10.1007/s10461-018-2051-3 · Cited by 102
“Taking this one step further, the strong association between having psychiatric disorders and substance use disorders and engaging in HIV risk behaviors increases the chances of viral transmission and creation of new infections, while lessening the positive potential of treatment as prevention [78], incurring addition…”
BackgroundSelf-citationAmankwaa, I., Boateng, D., Quansah, D. Y., Akuoko, C. P., & Evans, C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204091 · Cited by 98
Dodd, S. J., Ruffins, J., & Arzola, D. (2018) · Sexuality Research and Social Policy · doi:10.1007/s13178-017-0287-8 · Cited by 15
Metadata
- Authors
- Cohen, M. S., McCauley, M., & Gamble, T. R.
- Venue
- Current Opinion in HIV and AIDS
- Published
- 2012-03
- Volume
- 7
- Issue
- 2
- Pages
- 99-105
- ISSN
- 1746-630X (ISSN-L)
- OpenAlex
- W2052123269
- Cited by
- 301
- References
- 48
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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