Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study
Open accessAbstract
OBJECTIVE: To assess associations between abacavir (ABC) use and systemic inflammation. DESIGN: Nested case-control study. METHODS: The Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) cohort participants who initiated ABC were matched, using propensity score methods, to ABC-unexposed persons. Levels of high-sensitivity C-reactive protein (hsCRP) (microg/ml), interleukin-6 (IL-6) (pg/ml), and D-dimer (microg/ml) were measured from pre-HAART and on-HAART plasma. Random-effects models compared markers by ABC exposure and by changes from pre-HAART levels. RESULTS: Biomarkers were measured in N = 508 matched pairs (328 women; 180 men). Pre-HAART levels did not differ by exposure group except that hsCRP levels were higher among WIHS women who subsequently used ABC (P = 0.04). Regardless of ABC use, mean hsCRP increases and D-dimer reductions were seen when comparing pre-HAART to on-HAART levels, in the overall group (28 and -27%), for MACS men (28 and -31%) and for WIHS women [29 and -24%, P < 0.01 for all]; IL-6 levels declined in MACS men (P = 0.02). No adjusted biomarker level differences existed by ABC exposure at the on-HAART visit. HIV RNA reductions correlated with D-dimer (r = 0.14, P < 0.01) and IL-6 (r = 0.12, P < 0.01) reductions. Associations between ABC use and mean biomarker levels were modified by pre-HAART antiretroviral therapy experience. Renal dysfunction was equally likely among non-ABC and ABC recipients. DISCUSSION: ABC use was not associated with plasma elevations in hsCRP, IL-6, and D-dimer. Mechanisms other than increased systemic inflammation may account for ABC's reported association with increased cardiovascular disease. HAART-associated reductions in D-dimer and IL-6 were apparent regardless of ABC use and were correlated with HIV RNA reductions.
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Cites
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
Rosenbaum, P., & Rubin, D. (1985) · The American Statistician · doi:10.2307/2683903 · Cited by 6,854 · see citing works
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.
Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Kaslow, R. A., Ostrow, D. G., Detels, R., Phair, J., Polk, B. F., & Rinaldo, C. R. (1987) · American Journal of Epidemiology · doi:10.1093/aje/126.2.310 · Cited by 1,195 · see citing works
Rosenbaum, P. R. (1987) · Journal of the American Statistical Association · doi:10.1080/01621459.1987.10478441 · Cited by 998 · see citing works
Ridley, D. M., & Jordaan, H. V. F. (1986) · Journal of Clinical Ultrasound · doi:10.1002/jcu.1870140619 · Cited by 861 · see citing works
Impact of HIV infection and HAART on serum lipids in men
Riddler, S. A. (2003) · JAMA · doi:10.1001/jama.289.22.2978 · Cited by 624 · see citing works
The Women's Interagency HIV Study: an Observational Cohort Brings Clinical Sciences to the Bench
Bacon, M. C., von Wyl, V., Alden, C. B., Sharp, G. B., Robison, E., Hessol, N. A., Gange, S. J., Barranday, Y., Holman, S., Weber, K. M., et al. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.9.1013-1019.2005 · Cited by 524 · see citing works
Groups, T. S. A. T. D. S. (2008) · AIDS · doi:10.1097/qad.0b013e32830fe35e · Cited by 329 · see citing works
How much is too much? Interleukin-6 and its signalling in atherosclerosis
Schuett, H., Luchtefeld, M., Grothusen, C., Grote, K., & Schieffer, B. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-05-0297 · Cited by 293 · see citing works
Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men
Kaplan, R. C., Kingsley, L., Gange, S. J., Benning, L., Jacobson, L. P., Lazar, J., Anastos, K., Tien, P. C., Sharrett, A. R., & Hodis, H. N. (2008) · AIDS · doi:10.1097/qad.0b013e328300581d · Cited by 265 · see citing works
Fibrin fragment D-dimer and the risk of future venous thrombosis
Cushman, M., Folsom, A. R., Wang, L., Aleksic, N., Rosamond, W. D., Tracy, R. P., & Heckbert, S. R. (2003) · Blood · doi:10.1182/blood-2002-05-1416 · Cited by 231 · see citing works
C-Reactive Protein Is a Marker for Human Immunodeficiency Virus Disease Progression
Lau, B. M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.1.64 · Cited by 212 · see citing works
Kingsley, L., Cuervo-Rojas, J., Muñoz, Á., Palella, F. J., Post, W. S., Witt, M. D., Budoff, M. J., & Kuller, L. H. (2008) · AIDS · doi:10.1097/qad.0b013e328306a6c5 · Cited by 121 · see citing works
Association of HIV Infection and HIV/HCV Coinfection With C-Reactive Protein Levels
Reingold, J. S., WANKE, C. A., Kotler, D. P., Lewis, C. E., Tracy, R. P., Heymsfield, S. B., Tien, P. C., Bacchetti, P., Scherzer, R., Grünfeld, C., et al. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181685727 · Cited by 107 · see citing works
C-Reactive Protein, Fibrin D-Dimer, and Risk of Ischemic Heart Disease
Lowe, G. D. O., Sweetnam, P. M., YARNELL, J. W. G., Rumley, A., Rumley, C. N., Bainton, D., & Ben‐Shlomo, Y. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000141842.27810.a9 · Cited by 64 · see citing works
Henry, K., Kitch, D. W., Dubé, M. P., Zackin, R. A., Parker, R. A., Sprecher, D. L., Hammer, S., & Currier, J. S. (2004) · PubMed · Cited by 39 · see citing works
Lundgren, J. D., Reiss, P., Worm, S. W., Weber, R. K., El-Sadr, W. M., Wit, S. D., Law, M. G., Monforte, A. D., Pradier, C., & Sabin, C. A. (2009) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 27 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- [5]Lang S Mary-Krause M Cotte L 2 Gilquin G Partisani M Simon A Impact of Specific NRTI and PI Exposure on the Risk of Myocardial Infarction: A Case-Control Study Nested within FHDH ANRS CO4 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8 - 11, 2009 Montreal, Canada Abstract 43LB
- [6]Cooper D Bloch M Humphries A Amin J Baker D Emery S Simplification with Fixed-dose Tenofovir/Emtricitabine or Abacavir/Lamivudine in Adults with Suppressed HIV Replication: The STEAL Study, a Randomized, Open-label, 96-Week, Non-inferiority Trial 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8 - 11, 2009 Montreal, Canada Abstract 576
- [8]Belloso W HOrellana LC Losso MH Grinsztejn B Veloso VG 4 Ismerio Moreira R Predictive factors of serious vascular events in HIV patients in LATINA (LATInamerican Network on AIDS) 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention July 19-22, 2009 Cape Town, South Africa Abstr.TUPEB116
- [9]Benson C Ribaudo H Zheng E Koletar S Smurzynski M Bosch R No Association of Abacavir Use with Risk of Myocardial Infarction or Severe Cardiovascular Disease Events: Results from ACTG A5001 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8 - 11, 2009 Montreal, Canada Abstract 721
- [10]McComsey G Smith K Patel P Bellos N Sloan L Lackey P Similar Reductions in Markers of Inflammation and Endothelial Activation after Initiation of Abacavir/Lamivudine or Tenofovir/Emtricitabine: The HEAT Study 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8-11, 2009 Montreal, Canada Abst. 732
- [11]Bedimo R Westfall A Drechsler H Tebas P Abacavir use and risk of acute myocardial infarction and cerebrovascular disease in the HAART era 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention July 19-22, 2009 Cape Town, South Africa Abst. MOAB202
- [12]Martinez E Larrousse M Perez I Lonca M Podzamczer D Gutierrez F No evidence for recent abacavir/lamivudine use in promoting inflammation, endothelial dysfunction, hypercoagulability, or insulin resistance in virologically suppressed HIV-infected patients: a substudy of the BICOMBO randomized clinical trial (ISRCTN6189) 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention July 19-22, 2009 Cape Town, South Africa Abst. MOAB203
- [24]Hsue P Wu Y Schnell A Ganz P Hunt P Hatano H Association of Abacavir and HIV Disease Factors with Endothelial Function in Patients on Long-term Suppressive ART 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8 - 11, 2009 Montreal, Canada Abstract 723
- [31]Grunfeld C Delaney J Wanke C Currier J Scherzer R Biggs M HIV Infection Is an Independent Risk Factor for Atherosclerosis Similar in Magnitude to Traditional Cardiovascular Disease Risk Factors 16th Conference on Retroviruses and Opportunistic Infections (CROI 2009) February 8 - 11, 2009 Montreal, Canada Abstract 146
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Systemic Effects of Inflammation on Health during Chronic HIV Infection
Deeks, S. G., Tracy, R. P., & Douek, D. C. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.001 · Cited by 871 · see citing works
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522 · see citing works
T cell activation predicts carotid artery stiffness among HIV-infected women
Kaplan, R. C., Sinclair, E., LANDAY, A. L., Lurain, N. S., Sharrett, A. R., Gange, S. J., Xue, X., Parrinello, C. M., Hunt, P. W., Deeks, S. G., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.011 · Cited by 123 · see citing works
Cardiovascular disease in HIV infection
Palella, F. J., & Phair, J. (2011) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328347876c · Cited by 115 · see citing works
Castillo‐Mancilla, J., Brown, T. T., Erlandson, K. M., Palella, F. J., Gardner, E. M., Macatangay, B. J. C., Breen, E. C., Jacobson, L. P., Anderson, P. L., & Wada, N. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw650 · Cited by 101 · see citing works
McComsey, G. A., Kitch, D. W., Daar, E. S., Tierney, C., Jahed, N. C., Melbourne, K. M., Ha, B., Brown, T. T., Bloom, A. A., Fedarko, N. S., et al. (2012) · AIDS · doi:10.1097/qad.0b013e328354f4fb · Cited by 94 · see citing works
Satchell, C. S., O’Halloran, J. A., Cotter, A. G., Peace, A. J., O’Connor, E., Tedesco, A. F., Feeney, E. R., Lambert, J. S., Sheehan, G. J., Kenny, D. J., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir509 · Cited by 91 · see citing works
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Baker, J. V., Sharma, S., Grund, B., Rupert, A. W., Metcalf, J. A., Schechter, M., Munderi, P., Aho, I., Emery, S., Babiker, A. G., et al. (2017) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofx262 · Cited by 83 · see citing works
Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase
Baum, P. D., Sullam, P. M., Stoddart, C. A., & McCune, J. M. (2011) · AIDS · doi:10.1097/qad.0b013e32834d3cc3 · Cited by 75 · see citing works
Baker, J. V., Brummel‐Ziedins, K. E., Neuhaus, J., Duprez, D. A., Cummins, N. W., Dalmau, D., DeHovitz, J. A., Lehmann, C., Sullivan, A. K., Woolley, I. J., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000264 · Cited by 71 · see citing works
Hanna, D. B., Guo, M., Bůžková, P., Miller, T. L., Post, W. S., Stein, J. H., Currier, J. S., Kronmal, R. A., Freiberg, M. S., Bennett, S., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw261 · Cited by 71 · see citing works
Dorjee, K., Choden, T., Baxi, S. M., Steinmaus, C., & Reingold, A. L. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.07.010 · Cited by 66 · see citing works
Hattab, S., Guiguet, M., Carcelain, G., Fourati, S., Guihot, A., Autran, B., Caby, F., Marcelin, A., Costagliola, D. G., & Katlama, C. (2015) · HIV Medicine · doi:10.1111/hiv.12257 · Cited by 62 · see citing works
Kaplan, R. C., LANDAY, A. L., Hodis, H. N., Gange, S. J., Norris, P. J., Young, M., Anastos, K., Tien, P. C., Xue, X., Lazar, J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825b03be · Cited by 60 · see citing works
Freiberg, M. S., Bebu, I., Tracy, R. P., So‐Armah, K., Okulicz, J. F., Ganesan, A., Armstrong, A. W., O’Bryan, T. A., Rimland, D., Justice, A. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152588 · Cited by 57 · see citing works
Chronic HIV disease and activation of the coagulation system
Baker, J. V. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.08.016 · Cited by 52 · see citing works
Mooney, S., Tracy, R. P., Osler, T. M., & Grace, C. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144312 · Cited by 52 · see citing works
Cardiovascular toxicity of abacavir
Álvarez, Á., Orden, S., Andújar, I., Collado‐Díaz, V., Núñez-Delgado, S., Galindo, M. J., Estrada, V., Apostolova, N., & Esplugues, J. V. (2017) · AIDS · doi:10.1097/qad.0000000000001547 · Cited by 47 · see citing works
Dorjee, K., Baxi, S. M., Reingold, A. L., & Hubbard, A. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2808-8 · Cited by 43 · see citing works
Wohl, D. A., Arnoczy, G. S., Fichtenbaum, C. J., Campbell, T., Taiwo, B., Hicks, C. B., McComsey, G. A., Koletar, S. L., Sax, P. E., Tebas, P., et al. (2013) · Antiviral Therapy · doi:10.3851/imp2681 · Cited by 40 · see citing works
Hatano, H., Scherzer, R., Wu, Y., Harvill, K., Maka, K., Hoh, R., Sinclair, E., Palmer, S., Martin, J. N., Busch, M. P., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31826e7d0f · Cited by 38 · see citing works
Herold, B. C., Keller, M. J., Shi, Q., Hoover, D. R., Carpenter, C., Huber, A. M., Parikh, U. M., Agnew, K. J., MINKOFF, H. L., Colie, C. F., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182961cfc · Cited by 38 · see citing works
Padilla, S., Masiá, M., García, N., Jarrín, I., Tormo, C., & Gutiérrez, F. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-40 · Cited by 34 · see citing works
Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities
Pandrea, I., LANDAY, A. L., Wilson, C. C., Stock, J. L., Tracy, R. P., & Apetrei, C. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-014-0245-5 · Cited by 32 · see citing works
Okay, G., Koç, M. M., Güler, E. M., Yabacı, A., Koçyiğit, A., & Akkoyunlu, Y. (2020) · Current HIV Research · doi:10.2174/1570162x18666200712174642 · Cited by 31 · see citing works
HIV Disease Activity as a Modulator of Lipoprotein(a) and Allele-Specific Apolipoprotein(a) Levels
Enkhmaa, B., Anuurad, E., Zhang, W., Abbuthalha, A., Li, X., Dotterweich, W., Pollard, R. B., Asmuth, D. M., & Berglund, L. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300125 · Cited by 31 · see citing works
Castillo‐Mancilla, J., Morrow, M., Boum, Y., Byakwaga, H., Haberer, J. E., Martin, J. N., Bangsberg, D. R., MaWhinney, S., Musinguzi, N., Huang, Y., et al. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001629 · Cited by 31 · see citing works
Brouwer, E., Napravnik, S., Eron, J. J., Stalzer, B., Floris-Moore, M., Simpson, R. J., & Stürmer, T. (2014) · Epidemiology · doi:10.1097/ede.0000000000000041 · Cited by 30 · see citing works
In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
Papakonstantinou, V. D., Chini, M., Mangafas, N., Stamatakis, G. M., Tsogas, N., Τσούπρας, Α., Psarra, K., Fragopoulou, E., Antonopoulou, S., Gargalianos, P., et al. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-90 · Cited by 26 · see citing works
Can Biomarkers Advance HIV Research and Care in the Antiretroviral Therapy Era?
Justice, A. C., Erlandson, K. M., Hunt, P. W., LANDAY, A. L., Miotti, P., & Tracy, R. P. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix586 · Cited by 25 · see citing works
Ticona, E., Bull, M. E., Soria, J., Tapia, K. A., Legard, J., Styrchak, S. M., Williams, C. M., Mitchell, C. M., Rosa, A. L., Coombs, R. W., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000758 · Cited by 25 · see citing works
the Bicombo-met Substudy Team, Saumoy, M., Ordóñez‐Llanos, J., Martínez, E., Barragán, P., Ribera, E., Bonet, R., Knobel, H., Negredo, E., Loncà, M., et al. (2010) · Antiviral Therapy · doi:10.3851/imp1785 · Cited by 24 · see citing works
Associations between antiretroviral use and subclinical coronary atherosclerosis
Thomas, G. P., Li, X., Post, W. S., Jacobson, L. P., Witt, M. D., Brown, T. T., Kingsley, L., Phair, J., & Palella, F. J. (2016) · AIDS · doi:10.1097/qad.0000000000001220 · Cited by 22 · see citing works
Lake, J. E., Vo, Q., Jacobson, L. P., Sacktor, N. C., Miller, E. N., Post, W. S., Becker, J. T., Palella, F. J., Ragin, A. B., Martin, E. M., et al. (2015) · Antiviral Therapy · doi:10.3851/imp2952 · Cited by 22 · see citing works
Hileman, C. O., Wohl, D. A., Tisch, D. J., Debanne, S. M., & McComsey, G. A. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2012.0034 · Cited by 22 · see citing works
Atherosclerotic Cardiovascular Disease and Anti-Retroviral Therapy
Kaplan‐Lewis, E., Aberg, J. A., & Lee, M.-K. (2016) · Current HIV/AIDS Reports · doi:10.1007/s11904-016-0331-y · Cited by 21 · see citing works
Interleukin 10 Responses Are Associated With Sustained CD4 T-Cell Counts in Treated HIV Infection
Villacres, M. C., Kono, N., Mack, W. J., Nowicki, M. J., Anastos, K., Augenbraun, M. H., Liu, C., LANDAY, A. L., Greenblatt, R. M., Gange, S. J., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis380 · Cited by 19 · see citing works
Inflammatory Markers Associated with Coronary Heart Disease in Persons with HIV Infection
Fichtenbaum, C. J. (2010) · Current Infectious Disease Reports · doi:10.1007/s11908-010-0153-9 · Cited by 18 · see citing works
Coronary Artery Disease in Patients with HIV Infection
Patel, A., & Budoff, M. J. (2015) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-015-0105-8 · Cited by 17 · see citing works
for the SUPPORT Study Team, Kumar, P. N., DeJesus, E., Huhn, G. D., Sloan, L. M., Small, C. B., Edelstein, H. E., Felizarta, F., Hao, R. M., Ross, L., et al. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-269 · Cited by 17 · see citing works
Longitudinal evaluation of markers of inflammation in HIV ‐positive and HIV ‐negative Rwandan women
Kiefer, E., Hoover, D. R., Shi, Q., Dusingize, J. C., Sinayobye, J. D., & Anastos, K. (2018) · HIV Medicine · doi:10.1111/hiv.12665 · Cited by 16 · see citing works
Tincati, C., Mondatore, D., Bai, F., Monforte, A. D., & Marchetti, G. C. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa340 · Cited by 15 · see citing works
Abacavir/lamivudine fixed-dose combination antiretroviral therapy for the treatment of HIV
Achenbach, C. J., Scarsi, K. K., & Murphy, R. L. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0006-9 · Cited by 15 · see citing works
Parikh, S. M., Obuku, E. A., Walker, A. S., Semeere, A., Auerbach, B. J., Hakim, J. G., Mayanja‐Kizza, H., Mugyenyi, P. N., Salata, R. A., Kityo, C. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076158 · Cited by 12 · see citing works
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Patel, P., Bush, T. J., Overton, T., Baker, J. V., Hammer, J., Kojic, E. M., Conley, L. J., Henry, K., Brooks, J. T., & the SUN Study Investigators (2011) · Antiviral Therapy · doi:10.3851/imp2020 · Cited by 11 · see citing works
Current advances in pharmacovigilance in the USA and Europe
Marcus, K. A., Sorbello, A. F., Truffa, M. M., Williams, J., Raine, J. M., & Powderly, W. G. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328354dcac · Cited by 11 · see citing works
Chan, P., Yoon, B., Colby, D. J., Kroon, E. D. M. B., Sacdalan, C., Sriplienchan, S., Pinyakorn, S., Ananworanich, J., Valcour, V., Vasan, S., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac466 · Cited by 11 · see citing works
Moran, C. A., Sheth, A. N., Mehta, C. C., Hanna, D. B., Gustafson, D., Plankey, M. W., Mack, W. J., Tien, P. C., French, A. L., Golub, E. T., et al. (2018) · AIDS · doi:10.1097/qad.0000000000001785 · Cited by 10 · see citing works
Simpson, K., Chen, S., Wu, A., Boulanger, L., Chambers, R. B., Nedrow, K., Tawadrous, M., Pashos, C., & Haider, S. (2014) · HIV Medicine · doi:10.1111/hiv.12145 · Cited by 8 · see citing works
Arribas, J. R., Hill, A., Xi, N., van Delft, Y., & Moecklinghoff, C. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks102 · Cited by 8 · see citing works
Luca, A. D., Donati, K. D. G., Cozzi‐Lepri, A., Colafigli, M., Curtis, A. D., Capobianchi, M. R., Antinori, A., Giacometti, A., Magnani, G., Vullo, V., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318259875b · Cited by 6 · see citing works
Shahmanesh, M., Phillips, K. L., Boothby, M., & Tomlinson, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117164 · Cited by 5 · see citing works
HIV Infection and Acute Stroke: A Case Report and a Review of the Literature
Assallum, H., Alkayem, M., & Shabarek, N. (2013) · Case Reports in Medicine · doi:10.1155/2013/892054 · Cited by 4 · see citing works
Bagchi, S., Burrowes, S. A. B., Fantry, L. E., Hossain, M. B., Tollera, G. H., Kottilil, S., Pauza, C. D., Miller, M. J., Baumgarten, M., & Redfield, R. (2017) · SAGE Open Medicine · doi:10.1177/2050312117725644 · Cited by 4 · see citing works
Haile, Z. T., Sarfo, B. Y., Bonney, E. Y., Mensah, E. A., & Deletsu, S. D. (2020) · Current HIV Research · doi:10.2174/1570162x18666200817111152 · Cited by 3 · see citing works
Drabe, C. H., Rönsholt, F. F., Jakobsen, D. M., Ostrowski, S. R., Gerstoft, J., & Helleberg, M. (2022) · The Open AIDS Journal · doi:10.2174/18746136-v16-e2206200 · Cited by 2 · see citing works
Hullsiek, P. R. H. (2014) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000278 · Cited by 2 · see citing works
Moore-Igwe, B. W., Jacob, R. B., Christian, S. G., & Eze, E. M. (2022) · International Journal of Immunology · doi:10.11648/j.iji.20221001.12 · Cited by 1 · see citing works
From lipodystrophy to cardiovascular disease: new insight into the management of HIV infection
Guaraldi, G., & Zona, S. (2010) · Clinical Lipidology · doi:10.2217/clp.10.32
Influence of haart on the functional state of cardiovascular system (reference review)
Возна, Х. І. (2015) · Bukovinian Medical Herald · doi:10.24061/2413-0737.xix.1.73.2015.51
HEFFICON: HIV Effectiveness Italian Conference.
Antinori, A., Andreoni, M., Perno, C. F., & Lazzarin, A. (2015) · PubMed
- Authors
- Palella, F. J., Gange, S. J., Benning, L., Jacobson, L., Kaplan, R. C., Landay, A. L., Tracy, R. P., & Elion, R.
- Affiliations
- Northwestern University (US)
- Johns Hopkins University (US)
- Albert Einstein College of Medicine (US)
- Rush University Medical Center (US)
- University of Vermont (US)
- George Washington University (US)
- Corresponding author
- Palella, Frank J
- Venue
- AIDS
- Published
- 2010-07-17
- Volume
- 24
- Issue
- 11
- Pages
- 1657-1665
- ISSN
- 0269-9370 (ISSN-L)
- PMC
- PMC3514460
- OpenAlex
- W1979036222
- Cited by
- 61
- References
- 21
- Citations by year
- 2022: 3 · 2020: 3 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases
- National Center for Research Resources (M01RR000048)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- abacavir, systemic inflammation, C-reactive protein, interleukin-6, D-dimer, HIV infection, antiretroviral therapy, highly active antiretroviral therapy, cardiovascular risk, renal dysfunction, HIV RNA suppression, Women's Interagency HIV Study, Multicenter AIDS Cohort Study
- MeSH terms
- Abacavir, Adult, C-Reactive Protein, Female, Fibrin Fibrinogen Degradation Products, Humans, Inflammation, Male, Middle Aged, RNA, Viral, Dideoxynucleosides, Biomarkers, HIV-1, HIV Infections, Interleukin-6, Case-Control Studies, Inflammation Mediators, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Antiretroviral Therapy, Highly Active
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