CoChat
Sign Up
Cited by 624HIV-related health complications and treatmentsLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Impact of HIV infection and HAART on serum lipids in men

Open access
Riddler, Sharon A.·2003·JAMA
DOI 10.1001/jama.289.22.2978
Open this paper in CoChat — free account

Abstract

CONTEXT: Alterations in serum lipid values have been widely reported among persons infected with human immunodeficiency virus (HIV) type 1 treated with highly active antiretroviral therapy (HAART), but no data have yet been reported on changes from preseroconversion lipid values. OBJECTIVE: To describe changes in serum cholesterol levels associated with HIV infection and antiretroviral medication exposure, and 1-time assessment of triglyceride levels post-HAART initiation. DESIGN, SETTING, AND PARTICIPANTS: The Multicenter AIDS Cohort Study, a prospective study in which homosexual and bisexual men were enrolled and from which 50 of 517 HIV seroconverters were drawn for the analysis herein, who later initiated HAART, involving measurements of stored serum samples obtained between 1984 and 2002. MAIN OUTCOME MEASURES: Changes in levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) at 6 time points during an average of 12 years; 1-time assessment of triglyceride levels from the third post-HAART clinic visit. RESULTS: Among the 50 men, notable declines in mean serum TC (-30 mg/dL [-0.78 mmol/L]), HDL-C (-12 mg/dL [-0.31 mmol/L]), and LDL-C values (-22 mg/dL [-0.57 mmol/L]) were observed after HIV infection. Following HAART initiation, there were large increases in mean TC and LDL-C values (50 and 21 mg/dL [1.30 and 0.54 mmol/L], respectively); however, the mean changes from the preseroconversion values were 20 mg/dL (0.52 mmol/L) (95% confidence interval [CI], -1 to 41) and -1 mg/dL (-0.03 mmol/L) (95% CI, -25 to 22), respectively. Mean HDL-C remained below baseline levels throughout follow-up. The median value (interquartile range) of triglycerides was 225 mg/dL (2.54 mmol/L) (147-331 mg/dL). CONCLUSIONS: Before treatment, HIV infection results in substantial decreases in serum TC, HDL-C, and LDL-C levels. Subsequent HAART initiation is associated with increases in TC and LDL-C but little change in HDL-C. Increases in TC and LDL-C observed after about 3 years of HAART possibly represent a return to preinfection serum lipid levels after accounting for expected age-related changes.

Integrity signals

Registry

Crossref · 10.1001/jama.289.22.2978

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • HIV-infected patients typically have low total cholesterol and LDL-C, low HDL-C and increased triglycerides.

    “HIV-infected patients typically have low TC and LDL-C, as well as low HDL-C and increased TGs.430,431”

    From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [430]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Riddler, S. A.
Affiliations
University of Pittsburgh (US)
Corresponding author
Riddler, Sharon A.
ORCID
Riddler, Sharon A.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2003-06-11
Volume
289
Issue
22
Pages
2978
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.289.22.2978
OpenAlex
W2073738273
Cited by
624
References
25
Citations by year
2026: 5 · 2025: 10 · 2024: 15 · 2023: 17 · 2022: 15 · 2021: 25 · 2020: 11 · 2019: 24 · 2018: 20 · 2017: 20 · 2016: 32 · 2015: 28 · 2014: 41 · 2013: 38 · 2012: 38
FWCI
25.40
Type
journal article
Language
en
Open access
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Abbott Laboratories
  • Bristol-Myers Squibb
  • Pfizer
  • GlaxoSmithKline
  • F. Hoffmann-La Roche
  • Northwestern University
  • Johns Hopkins University
  • University of Pittsburgh
  • Jaeb Center for Health Research
  • National Institutes of Health (5r21de015166-02)
  • University of California, Los Angeles
  • Johns Hopkins Bloomberg School of Public Health
  • National Institute of Allergy and Infectious Diseases (U01 AI 35039, U01AI035041, P01 AI-43664, U01AI046383, U01-AI-35041, U01AI035039, U01 AI46383, P01AI043664)
  • National Institute of Dental and Craniofacial Research (DE 15166)
Topics
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
HIV infection, highly active antiretroviral therapy, serum lipids, cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, HIV seroconversion, men who have sex with men, Multicenter AIDS Cohort Study, HIV-associated dyslipidemia
MeSH terms
Adult, HIV Seropositivity, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Regression Analysis, Triglycerides, HIV-1, HIV Infections, Anti-HIV Agents, Antiretroviral Therapy, Highly Active

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review