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IL-12, TNF-α, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times

Elenkov, Ilia J., Wilder, Ronald L., Bakalov, Vladimir K., Link, Amrey A., Dimitrov, Mariana A., Fisher, Scott, Crane, Marianna, Kanik, Keith S., Chrousos, George P.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.10.7905
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Abstract

Clinical observations indicate that some autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, frequently remit during pregnancy but exacerbate, or have their onset, in the postpartum period. The immune basis for these phenomena is poorly understood. Recently, excessive production of IL-12 and TNF-alpha was causally linked to rheumatoid arthritis and multiple sclerosis. We studied 18 women with normal pregnancies in their third trimester and during the early postpartum period. We report that during the third trimester pregnancy, ex vivo monocytic IL-12 production was about 3-fold and TNF-alpha production was approximately 40% lower than postpartum values. At the same time, urinary cortisol and norepinephrine excretion and serum levels of 1,25-dihydroxyvitamin were 2- to 3-fold higher than postpartum values. As shown previously, these hormones can directly suppress IL-12 and TNF-alpha production by monocytes/macrophages in vitro. We suggest that a cortisol-, norepinephrine-, and 1,25-dihydroxyvitamin-induced inhibition and subsequent rebound of IL-12 and TNF-alpha production may represent a major mechanism by which pregnancy and postpartum alter the course of or susceptibility to various autoimmune disorders.

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Metadata

Authors
Elenkov, I. J., Wilder, R. L., Bakalov, V. K., Link, A. A., Dimitrov, M. A., Fisher, S., Crane, M., Kanik, K. S., & Chrousos, G. P.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-10-01
Volume
86
Issue
10
Pages
4933-4938
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.10.7905
OpenAlex
W2143241373
Cited by
272
References
0
FWCI
4.52
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: IL-12, TNF-α, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times. https://app.cochat.ai/papers/10.1210/jcem.86.10.7905
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Elenkov, I. J., Wilder, R. L., Bakalov, V. K., Link, A. A., Dimitrov, M. A., Fisher, S., Crane, M., Kanik, K. S., & Chrousos, G. P. (2001). IL-12, TNF-α, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.86.10.7905

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