The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Supplementation With Multivitamins and Vitamin A and Incidence of Malaria Among HIV-Infected Tanzanian Women
Open accessAbstract
INTRODUCTION: HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age. METHODS: HIV-infected pregnant Tanzanian women recruited into the study were randomly assigned to daily multivitamins (B complex, C, and E), vitamin A alone, both multivitamins and vitamin A, or placebo. Women received malaria prophylaxis during pregnancy and were followed monthly during the prenatal and postpartum periods. Malaria was defined in 2 ways: presumptive diagnosis based on a physician's or nurse's clinical judgment, which in many cases led to laboratory investigations, and periodic examination of blood smears for malaria parasites. RESULTS: Multivitamin supplementation compared with no multivitamins significantly lowered women's risk of presumptively diagnosed clinical malaria (relative risk: 0.78, 95% confidence interval: 0.67 to 0.92), although multivitamins increased their risk of any malaria parasitemia (relative risk: 1.24, 95% confidence interval: 1.02 to 1.50). Vitamin A supplementation did not change malaria incidence during the study. CONCLUSIONS: Multivitamin supplements have been previously shown to reduce HIV disease progression among HIV-infected women, and consistent with that, these supplements protected against development of symptomatic malaria. The clinical significance of increased risk of malaria parasitemia among supplemented women deserves further research, however. Preventive measures for malaria are warranted as part of an integrated approach to the care of HIV-infected individuals exposed to malaria.
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“These measures include IPTp-SP, the use of ITNs and the use of IRS in conjunction with nutritional interventions [130, 160, 181, 194].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [160]
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“In contrast, another study reported that vitamin A supplementation did not change the incidence of malaria during the study [160].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [160]
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Doolan, D. L., Dobaño, C., & Baird, J. K. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00025-08 · Cited by 1,363
The burden of malaria in pregnancy in malaria-endemic areas
Steketee, R., Nahlen, B., Parise, M., & Menendez, C. (2001) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.28 · Cited by 1,063
Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study
Dellicour, S., Tatem, A. J., Guerra, C. A., Snow, R. W., & ter Kuile, F. O. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000221 · Cited by 490
Whitworth, J., Morgan, D., QUIGLEY, M. A., Smith, A. D., Mayanja, B. N., Eotu, H., Omoding, N., Okongo, M. J., Malamba, S. S., & Ojwiya, A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02727-6 · Cited by 471
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Self-citationA Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality
Fawzi, W. W., Msamanga, G. I., Spiegelman, D., Wei, R., Kapiga, S., Villamor, E., Mwakagile, D., Mugusi, F., Hertzmark, E., Essex, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040541 · Cited by 446
Self-citationter Kuile, F. O., Parise, M. E., Verhoeff, F. H., Udhayakumar, V., Newman, R. D., van Eijk, A. M., Rogerson, S. J., & Steketee, R. W. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.41 · Cited by 364
Kublin, J. G., Patnaik, P., Jere, C. S., Miller, W. C., Hoffman, I., Chimbiya, N., Pendame, R., Taylor, T. E., & Molyneux, M. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17743-5 · Cited by 283
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Multiple-micronutrient supplementation for women during pregnancy
Haider, B. A., & Bhutta, Z. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004905.pub5 · Cited by 740
The Role of Vitamin E in Immunity
Lee, G. Y., & Han, S. N. (2018) · Nutrients · doi:10.3390/nu10111614 · Cited by 582
Multiple-micronutrient supplementation for women during pregnancy
Keats, E. C., Haider, B. A., Tam, E. W. Y., & Bhutta, Z. A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004905.pub6 · Cited by 418
Vitamin A and Pregnancy: A Narrative Review
Bastos Maia, S., Rolland Souza, A. S., Costa Caminha, M. D. F., Lins da Silva, S., Callou Cruz, R. D. S. B. L., Carvalho dos Santos, C., & Batista Filho, M. (2019) · Nutrients · doi:10.3390/nu11030681 · Cited by 228
Vitamin A supplementation during pregnancy for maternal and newborn outcomes
van den Broek, N. R., Dou, L., Othman, M., Neilson, J. P., Gates, S., & Gülmezoglu, A. M. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008666.pub2 · Cited by 171
Metadata
- Authors
- Olofin, I. O., Spiegelman, D., Aboud, S., Duggan, C., Danaei, G., & Fawzi, W. W.
- Affiliations
- Boston Children's Hospital (US)
- Harvard University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- Corresponding author
- Olofin, Ibironke O.
- Spiegelman, Donna
- Danaei, Goodarz
- Fawzi, Wafaie W.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2014-12-01
- Volume
- 67
- Issue
- Supplement 4
- Pages
- S173-S178
- ISSN
- 1525-4135 (ISSN-L)
- PMC
- PMC4251912
- OpenAlex
- W2134137086
- Cited by
- 30
- References
- 39
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IHI Repository (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Muhimbili University of Health and Allied Sciences
- University of Health and Allied Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK104676, P30DK040561)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD058795)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
- Keywords
- multivitamin supplementation, vitamin A supplementation, malaria incidence, HIV infection, pregnant women, malaria parasitaemia, malaria prophylaxis, B vitamins, vitamin C, vitamin E
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Female, Humans, Middle Aged, Postnatal Care, Pregnancy, Pregnancy Complications, Infectious, Prenatal Care, Tanzania, Vitamin A, Vitamin B Complex, Vitamin E, HIV Infections, Comorbidity, Incidence, Malaria, Falciparum, Dietary Supplements, Young Adult
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