The Role of Vitamin E in Immunity

Lee, Ga Young; Han, Sung Nim

doi:10.3390/nu10111614

Cited by 582Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesT-cell and B-cell Immunology

The Role of Vitamin E in Immunity

Open access

Lee, Ga Young, Han, Sung Nim·2018·Nutrients

DOI 10.3390/nu10111614PMC PMC6266234

Open this paper in CoChat — free account Open PDF

Abstract

Vitamin E is a fat-soluble antioxidant that can protect the polyunsaturated fatty acids (PUFAs) in the membrane from oxidation, regulate the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and modulate signal transduction. Immunomodulatory effects of vitamin E have been observed in animal and human models under normal and disease conditions. With advances in understating of the development, function, and regulation of dendritic cells (DCs), macrophages, natural killer (NK) cells, T cells, and B cells, recent studies have focused on vitamin E’s effects on specific immune cells. This review will summarize the immunological changes observed with vitamin E intervention in animals and humans, and then describe the cell-specific effects of vitamin E in order to understand the mechanisms of immunomodulation and implications of vitamin E for immunological diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/nu10111614

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vitamin E protects against lipid peroxidation and slows skin ageing owing to its antioxidant properties and ability to scavenge free radicals and become part of lipid structures.
“Owing to the antioxidant properties of vitamin E and its ability to scavenge free radicals and become part of lipid structures, it protects against lipid peroxidation and slows skin ageing [80].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [80]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,501 · see citing works
Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
Meydani, S. N., Barklund, M., Liu, S., Meydani, M., Miller, R. A., Cannon, J., Morrow, F. D., Rocklin, R. E., & Blumberg, J. B. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.3.557 · Cited by 585 · see citing works
Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects: A Randomized Controlled Trial
Meydani, S. N. (1997) · JAMA · doi:10.1001/jama.1997.03540410058031 · Cited by 545 · see citing works
The role of dendritic cells in autoimmunity
Ganguly, D., Haak, S., Sisirak, V., & Reizis, B. (2013) · Nature reviews. Immunology · doi:10.1038/nri3477 · Cited by 508 · see citing works
Dendritic cell metabolism
Pearce, E. J., & Everts, B. (2014) · Nature reviews. Immunology · doi:10.1038/nri3771 · Cited by 482 · see citing works
Vitamin E Regulatory Mechanisms
Traber, M. G. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093819 · Cited by 414 · see citing works
Effect of Vitamin E and Selenium Supplementation on Incidence of Clinical Mastitis and Duration of Clinical Symptoms
Smith, K. L., Harrison, J. H., Hancock, D. D., Todhunter, D. A., & Conrad, H. R. (1984) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(84)81436-8 · Cited by 311 · see citing works
Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents: A Randomized Controlled Trial
Meydani, S. N., Leka, L. S., Fine, B. C., Dallal, G. E., Keusch, G. T., Singh, M. F., & Hamer, D. H. (2004) · JAMA · doi:10.1001/jama.292.7.828 · Cited by 290 · see citing works
Vitamin E supplementation suppresses prostaglandin E21 synthesis and enhances the immune response of aged mice
Meydani, S. N., Meydani, M., Verdon, C. P., Shapiro, A. A., Blumberg, J. B., & Hayes, K. C. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90034-5 · Cited by 277 · see citing works
Dendritic cell maturation and cross‐presentation: timing matters!
Alloatti, A., Kotsias, F., Magalhaes, J. G., & Amigorena, S. (2016) · Immunological Reviews · doi:10.1111/imr.12432 · Cited by 244 · see citing works
Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function.
Stiff, A., Trikha, P., Mundy-Bosse, B., McMichael, E., Mace, T. A., Benner, B., Kendra, K., Campbell, A., Gautam, S., Abood, D., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0691 · Cited by 244 · see citing works
Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
Meydani, S. N., Han, S. N., & Wu, D. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00274.x · Cited by 234 · see citing works
Self-citation
Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons: A Randomized Controlled Trial
Graat, J. M., Schouten, E. G., & Kok, F. J. (2002) · JAMA · doi:10.1001/jama.288.6.715 · Cited by 230 · see citing works
Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis
Cannon, J. G., Meydani, S. N., Fielding, R. A., FIATARONE, M. A., Meydani, M., Farhangmehr, M., Orencole, S. F., Blumberg, J. B., & Evans, W. J. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.6.r1235 · Cited by 223 · see citing works
Inhibition of NF-κB and Oxidative Pathways in Human Dendritic Cells by Antioxidative Vitamins Generates Regulatory T Cells
Tan, P., Sagoo, P., Chan, C. C. W., Yates, J., Campbell, J., Beutelspacher, S. C., Foxwell, B. M. J., Lombardi, G., & George, A. J. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7633 · Cited by 220 · see citing works
Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y
Ravaglia, G., Forti, P., Maioli, F., Bastagli, L., Facchini, A., Mariani, E., Savarino, L., Sassi, S., Cucinotta, D., & Lenaz, G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.590 · Cited by 189 · see citing works
Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E
Wu, D., Mura, C. V., Beharka, A. A., Han, S. N., Paulson, K. E., Hwang, D. H., & Meydani, S. N. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.3.c661 · Cited by 164 · see citing works
Self-citation
Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus
Han, S. N., Wu, D., Ha, W. K., et al. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00070.x · Cited by 158 · see citing works
Self-citation
Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E
Beharka, A. A., Wu, D., Han, S. N., & Meydani, S. N. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01819-2 · Cited by 153 · see citing works
Self-citation
Analysis and Distribution of Vitamin E in Vegetable Oils and Foods
Sheppard, A. J., Pennington, J. A. T., & Weihrauch, J. L. (2023) · CRC Press eBooks · doi:10.1201/9781003418160-4 · Cited by 148 · see citing works
Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity
Adolfsson, O., Huber, B. T., & Meydani, S. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.3809 · Cited by 145 · see citing works
Dietary Vitamin E Requirement for Optimum Immune Responses in the Rat
Bendich, A., Gabriel, E., & Machlin, L. J. (1986) · Journal of Nutrition · doi:10.1093/jn/116.4.675 · Cited by 141 · see citing works
Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
Pallast, E. G., Schouten, E. G., de Waart, F. G., Fonk, H. C., Doekes, G., von Blomberg, B. M., & Kok, F. J. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1273 · Cited by 141 · see citing works
Enhanced expression of inducible cyclooxygenase with age in murine macrophages
Hayek, M. G., Mura, C. V., Wu, D., Beharka, A. A., Han, S. N., Paulson, K. E., Hwang, D. H., & Meydani, S. N. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2445 · Cited by 138 · see citing works
Self-citation
Vitamin E: A Role in Signal Transduction
Zingg, J.-M. A. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034347 · Cited by 133 · see citing works
α‐Tocopheryl succinate‐induced apoptosis in Jurkat T cells involves caspase‐3 activation, and both lysosomal and mitochondrial destabilisation
Neužil, J., Svensson, I., Weber, T., Weber, C., & Brunk, U. T. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00141-6 · Cited by 126 · see citing works
Mechanism of vitamin E inhibition of cyclooxygenase activity in macrophages from old mice: role of peroxynitrite
Beharka, A. A., Wu, D., Serafini, M., & Meydani, S. N. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00817-6 · Cited by 117 · see citing works
Effect of vitamin E supplementation on leukocyte function
Prasad, J. S. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.3.606 · Cited by 116 · see citing works
Age-Associated Decline in Effective Immune Synapse Formation of CD4+ T Cells Is Reversed by Vitamin E Supplementation
Marko, M. G., Ahmed, T., Bunnell, S. C., Wu, D., Chung, H., Huber, B. T., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1443 · Cited by 112 · see citing works
Vitamin E and immune response. I. Enhancement of helper T cell activity by dietary supplementation of vitamin E in mice.
Tanaka, J., Fujiwara, H., & Torisu, M. (1979) · PubMed · Cited by 108 · see citing works
Effects of vitamin E, inorganic selenium, bacterial organic selenium, and their combinations on immunity response in broiler chickens
Dalia, A. M., Loh, T. C., Sazili, A. Q., Jahromi, M. F., & Samsudin, A. A. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1578-x · Cited by 108 · see citing works
Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza
Hayek, M. G., Taylor, S. F., Bender, B. S., et al. (1997) · The Journal of Infectious Diseases · doi:10.1086/517265 · Cited by 107 · see citing works
High Dietary Intakes of Vitamin E and Cellular Immune Functions in Rats
Moriguchi, S., Kobayashi, N., & Kishino, Y. (1990) · Journal of Nutrition · doi:10.1093/jn/120.9.1096 · Cited by 97 · see citing works
Effect of Supplemental Vitamin E on the Immune System of Calves,
Reddy, P. G., Morrill, J. L., Minocha, H. C., et al. (1986) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(86)80382-4 · Cited by 96 · see citing works
Vitamin E is Immunostimulatory in Calves
Reddy, P. G., Morrill, J. L., Minocha, H. C., et al. (1987) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(87)80104-2 · Cited by 92 · see citing works
Untitled work
(2002) · PubMed · Cited by 92 · see citing works
Vitamin E administration may decrease the incidence of pneumonia in elderly males
Hemilä, H. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s114515 · Cited by 90 · see citing works
Protection of Chicks Against E. coli Infection by Dietary Supplementation with Vitamin E
Heinzerling, R. H., Nockels, C. F., Quarles, C. L., et al. (1974) · Experimental Biology and Medicine · doi:10.3181/00379727-146-38087 · Cited by 88 · see citing works
The α-Tocopherol Form of Vitamin E Reverses Age-Associated Susceptibility to Streptococcus pneumoniae Lung Infection by Modulating Pulmonary Neutrophil Recruitment
Ghanem, E. N. B., Clark, S. A., Du, X., Wu, D., Camilli, A., Leong, J. M., & Meydani, S. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402401 · Cited by 88 · see citing works
Vitamin E and Beta-Carotene Supplementation and Hospital-Treated Pneumonia Incidence in Male Smokers
Hemilä, H., Virtamo, J. R. K., Albanes, D., & Kaprio, J. A. (2004) · CHEST Journal · doi:10.1378/chest.125.2.557 · Cited by 77 · see citing works
Vitamin E Protects Mice Against Diplococcus pneumoniae Type I Infection
Heinzerling, R. H., Tengerdy, R. P., Wick, L. L., et al. (1974) · Infection and Immunity · doi:10.1128/iai.10.6.1292-1295.1974 · Cited by 76 · see citing works
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
Li‐Weber, M., Weigand, M. A., Giaisi, M., Süss, D., Treiber, M. K., Baumann, S., Ritsou, E., Breitkreutz, R., & Krammer, P. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15073 · Cited by 75 · see citing works
Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells
Han, S. N., Adolfsson, O., Lee, C., Prolla, T. A., Ordovás, J. M., & Meydani, S. N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6052 · Cited by 74 · see citing works
Self-citation
Vitamin E or Vitamin A Protects Chickens Against E. coli Infection
Tengerdy, R. P., & Nockels, C. F. (1975) · Poultry Science · doi:10.3382/ps.0541292 · Cited by 72 · see citing works
Klotho Prevents Translocation of NFκB
Buendía, P., Ramı́rez, R., Aljama, P., & Carracedo, J. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.02.005 · Cited by 68 · see citing works
Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
Mahalingam, D., Radhakrishnan, A. K., Amom, Z., Ibrahim, N., & Nesaretnam, K. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.184 · Cited by 67 · see citing works
Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects
Waart, F. G. D., Portengen, L., Doekes, G., Verwaal, C. J., & Kok, F. J. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970193 · Cited by 67 · see citing works
Vitamin E and aspirin depress prostaglandins in protection of chickens against Escherichia coli infection
Likoff, R. O., Guptill, D. R., Lawrence, L. M., et al. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.2.245 · Cited by 66 · see citing works
Increased vitamin E intake restores fish-oil-induced suppressed blastogenesis of mitogen-stimulated T lymphocytes
Kramer, T., Schoene, N. W., Douglass, L., Judd, J., Ballard-Barbash, R. R., Taylor, P., Bhagavan, H., & Nair, P. P. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.5.896 · Cited by 64 · see citing works
Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo
Dworski, R., Han, W., Blackwell, T. S., Hoskins, A., & Freeman, M. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.040 · Cited by 60 · see citing works
Nitric Oxide Synthase and Cyclooxygenase Pathways: A Complex Interplay in Cellular Signaling
Sorokin, A. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160729105312 · Cited by 60 · see citing works
α-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+dendritic cells in utero and allergic inflammation in neonates
Abdala‐Valencia, H., Berdnikovs, S., Soveg, F. W., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00132.2014 · Cited by 56 · see citing works
Effect of Supplemental Dietary Vitamin E on the Serologic Response of Swine to an Escherichia coli Bacterin
Ellis, R. P., & Vorhies, M. W. (1976) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1976.168.03.231 · Cited by 56 · see citing works
Oxidative‐inflammatory damage in cirrhosis: Effect of vitamin E and a fermented papaya preparation
Marotta, F., Yoshida, C., Rafael, B., Naito, Y., & Packer, L. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04937.x · Cited by 55 · see citing works
Vitamin C, Vitamin E, and Beta-Carotene in Relation to Common Cold Incidence in Male Smokers
Hemilä, H., Kaprio, J. A., Albanes, D., Heinonen, O. P., & Virtamo, J. R. K. (2002) · Epidemiology · doi:10.1097/00001648-200201000-00006 · Cited by 55 · see citing works
Long-Term Feeding of High Vitamin E Diet Improves the Decreased Mitogen Response of Rat Splenic Lymphocytes with Aging.
Sakai, S., & Moriguchi, S. (1997) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.43.113 · Cited by 52 · see citing works
Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice
Ren, Z., Pae, M., Dao, M. C., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.110.121434 · Cited by 50 · see citing works
Swine dysentery: the influence of dietary vitamin E and selenium on the clinical and pathological effects of Treponema hyodysenteriae infection in pigs
Teige, J., Tollersrud, S., Lund, A., et al. (1982) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)32445-7 · Cited by 48 · see citing works
The effect of antioxidant supplementation on hepatitis C viral load, transaminases and oxidative status: a randomized trial among chronic hepatitis C virus-infected patients
Groenbæk, K., Friis, H., Hansen, M., et al. (2006) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000231746.76136.4a · Cited by 47 · see citing works
A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
Hanson, M., Özenci, V., Carlsten, M., Glimelius, B. L. G., Frödin, J., Masucci, G. V., Malmberg, K., & Kiessling, R. V. R. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0261-4 · Cited by 47 · see citing works
Effect of vitamin E on the immune response to influenza virus vaccine and the incidence of infectious disease in man
Harman, D., & Miller, R. W. (1986) · AGE · doi:10.1007/bf02431896 · Cited by 45 · see citing works
Vitamin E-Enhanced Humoral Antibody Response to Clostridium Perfringens Type D in Sheep
Tengerdy, R. P., Meyer, D. L., Lauerman, L. H., et al. (1983) · British Veterinary Journal · doi:10.1016/s0007-1935(17)30538-9 · Cited by 45 · see citing works
High concentration of vitamin E supplementation in sow diet during the last week of gestation and lactation affects the immunological variables and antioxidative parameters in piglets
Lin, W., Xu, X., Su, G., Shi, B., & Shan, A. (2016) · Journal of Dairy Research · doi:10.1017/s0022029916000650 · Cited by 44 · see citing works
Vitamin E Reverses Impaired Linker for Activation of T Cells Activation in T Cells from Aged C57BL/6 Mice
Marko, M. G., Pang, H.-J. E., Ren, Z., Azzi, A., Huber, B. T., Bunnell, S. C., & Meydani, S. N. (2009) · Journal of Nutrition · doi:10.3945/jn.108.103416 · Cited by 42 · see citing works
Investigation of the Effects of Oral Administration of Vitamin E and Beta-Carotene on the Chemiluminescence Responses and the Frequency of Sister Chromatid Exchanges in Circulating Leukocytes from Cigarette Smokers
Richards, G. A., Theron, A. J., van Rensburg, C. E. J., et al. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.3.648 · Cited by 41 · see citing works
Improved Recovery of Vitamin E-Treated Lambs that have been Experimentally Infected with Intratracheal Chlamydia
Stephens, L. C., McChesney, A. E., & Nockels, C. F. (1979) · British Veterinary Journal · doi:10.1016/s0007-1935(17)32890-7 · Cited by 37 · see citing works
Long-Term Dietary Vitamin E Retards Development of Retrovirus-Induced Disregulation in Cytokine Production
Wang, Y., Huang, D. S., Eskelson, C. D., et al. (1994) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1994.1108 · Cited by 36 · see citing works
γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+dendritic cells in utero and allergic inflammation in neonates
Abdala‐Valencia, H., Soveg, F. W., & Cook‐Mills, J. M. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00301.2015 · Cited by 35 · see citing works
Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers
Radhakrishnan, A. K., Lee, A.-L., Wong, P.-F., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508039998 · Cited by 34 · see citing works
Effect of Concomitant Consumption of Fish Oil and Vitamin E on T Cell Mediated Function in the Elderly: A Randomized Double-Blind Trial
Wu, D., Han, S. N., Meydani, M., & Meydani, S. N. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719539 · Cited by 33 · see citing works
Self-citation
The Immune Response to Herpes Simplex Virus Encephalitis in Mice Is Modulated by Dietary Vitamin E
Sheridan, P. A., & Beck, M. A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.1.130 · Cited by 32 · see citing works
Long-term dietary antioxidant supplementation reduces production of selected inflammatory mediators by murine macrophages
Beharka, A. A., Han, S. N., Adolfsson, O., Wu, D., Smith, D. E., Lipman, R. D., Cao, G., Meydani, M., & Meydani, S. N. (2000) · Nutrition Research · doi:10.1016/s0271-5317(99)00160-8 · Cited by 31 · see citing works
Self-citation
Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age
Capó, X., Martorell, M., Sureda, A., Riera, J., Drobnic, F., Tur, J. A., & Pons, A. (2016) · Nutrients · doi:10.3390/nu8100619 · Cited by 31 · see citing works
Supplementation With Multivitamins and Vitamin A and Incidence of Malaria Among HIV-Infected Tanzanian Women
Olofin, I. O., Spiegelman, D., Aboud, S., Duggan, C., Danaei, G., & Fawzi, W. W. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000375 · Cited by 30 · see citing works
Vitamin E enhances the immune functions of young but not old mice under restraint stress
Wakikawa, A., Utsuyama, M., Wakabayashi, A., et al. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00055-8 · Cited by 29 · see citing works
Vitamin E, signalosomes and gene expression in T cells
Molano, A., & Meydani, S. N. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.11.002 · Cited by 29 · see citing works
Down to the origin: Cdc6 protein and the competence to replicate
Pelizon, C. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00024-2 · Cited by 29 · see citing works
CELLULAR IMMUNE RESPONSES, CORTICOSTEROID LEVELS, AND RESISTANCE TO LISTERIA MONOCYTOGENES AND MURINE LEUKEMIA IN MICE FED A HIGH VITAMIN E DIET*
WATSON, R. R., & Petro, T. M. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb31255.x · Cited by 27 · see citing works
Supplementation with tocotrienols from Bixa orellana improves the in vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of infected wound
Pierpaoli, E., Orlando, F., Cirioni, O., et al. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.011 · Cited by 26 · see citing works
Influence of Vitamins A and E on Gnotobiotic and Conventionally Maintained Rats Exposed to Mycoplasma pulmonis
Tvedten, H. W., Whitehair, C. K., & Langham, R. F. (1973) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1973.163.06.605 · Cited by 26 · see citing works
Depressed natural killer cell activity due to decreased natural killer cell population in a vitamin E-deficient patient with Shwachman syndrome: reversible natural killer cell abnormality by α-tocopherol supplementation
Adachi, N., Migita, M., Ohta, T., et al. (1997) · European Journal of Pediatrics · doi:10.1007/s004310050634 · Cited by 23 · see citing works
Klotho sensitive regulation of dendritic cell functions by vitamin E
Xuân, N. T., Trang, P. T. T., Phòng, N. V., et al. (2016) · Biological Research · doi:10.1186/s40659-016-0105-4 · Cited by 23 · see citing works
Moderate dietary supplementation with vitamin E enhances lymphocyte functionality in the adult cat
O'Brien, T., Thomas, D. G., Morel, P. C. H., et al. (2015) · Research in Veterinary Science · doi:10.1016/j.rvsc.2015.01.007 · Cited by 16 · see citing works
The Effect of Free Radical Scavengers on Outcome after Infection in Burned Mice
Fang, C., Peck, M. D., Alexander, W. J., et al. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199004000-00015 · Cited by 16 · see citing works
The effect of vitamin E supplementation on an experimental Haemonchus contortus infection in lambs
Wolf, B. M. D., Zajac, A. M., Hoffer, K. A., Sartini, B. L., Bowdridge, S. A. A., LaRoith, T., & Petersson, K. H. (2014) · Veterinary Parasitology · doi:10.1016/j.vetpar.2014.07.013 · Cited by 15 · see citing works
The Effect of Free Radical Scavengers on Outcome after Infection in Burned Mice
Fang, C., Peck, M. D., Alexander, W. J., et al. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199030040-00015 · Cited by 14 · see citing works
Superoxide generation in leukocytes and vitamin E.
OKANO, T., Tamai, H., & Mino, M. (1991) · PubMed · Cited by 12 · see citing works
The effect of vitamins A, E and K on experimentally induced histomoniasis in turkeys
Schildknecht, E. G., & Squibb, R. L. (1979) · Parasitology · doi:10.1017/s0031182000048551 · Cited by 10 · see citing works
Untitled work
Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

Flagged first, then by citations

Sorted by citations

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
Su, L.-J., Zhang, J.-H., Gomez, H., Murugan, R., Hong, X., Xu, D., Jiang, F., & Peng, Z.-Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5080843 · Cited by 2,166 · see citing works
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445 · see citing works
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345 · see citing works
“Vitamin E (tocopherol) wheat germ oil, sunflower oil, safflower oil, soybean oil, maize oil, cottonseed oil, palm oil, cereal products, nuts -takes part in biosynthesis of collagen, elastin and GAGs -protects lipid structures of the stratum corneum -prevents the development of UV-induced erythema -has strong antioxida…”
BackgroundInfluential
Could Vitamins Help in the Fight Against COVID-19?
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234 · see citing works
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147 · see citing works
Vitamin C and vitamin C plus E improve the immune function in the elderly
De la Fuente, M., Sánchez, C., Vallejo, C., Díaz-Del Cerro, E., Arnalich, F., & Hernanz, Á. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111118 · Cited by 68 · see citing works
Effect of vitamin supplementation on polycystic ovary syndrome and key pathways implicated in its development: A Mendelian randomization study
Shen, J.-Y., Xu, L., Ding, Y., & Wu, X.-Y. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i23.5468 · Cited by 7 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019
Cloning and Characterization of Rat BAT3 cDNA
Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works
EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS
Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint
Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works
Anthoxanthum Mosaic Virus
Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works

Authors: Lee, G. Y., & Han, S. N.
Affiliations: Seoul National University (KR)
Corresponding author: Han, Sung Nim
ORCID: Lee, Ga Young
Han, Sung Nim
Venue: Nutrients
Publisher: MDPI AG
Published: 2018-11-01
Volume: 10
Issue: 11
Pages: 1614
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu10111614
PMC: PMC6266234
OpenAlex: W2899298350
Cited by: 582
References: 90
Citations by year: 2026: 38 · 2025: 62 · 2024: 88 · 2023: 92 · 2022: 105 · 2021: 104 · 2020: 79 · 2019: 14
FWCI: 5.07
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Research Foundation of Korea (NRF) (NRF-2018R1D1A1B07049178)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: vitamin E, immunomodulation, antioxidants, polyunsaturated fatty acid oxidation, reactive oxygen species, reactive nitrogen species, signal transduction, dendritic cells, macrophages, natural killer cells, T cells, B cells, immune disorders
MeSH terms: Animals, Antioxidants, Humans, Immunity, Cellular, Vitamin E

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role of Vitamin E in Immunity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks