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Cited by 30Malaria Research and ControlHIV/AIDS Research and InterventionsChild Nutrition and Water Access

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

Supplementation With Multivitamins and Vitamin A and Incidence of Malaria Among HIV-Infected Tanzanian Women

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Olofin, Ibironke O., Spiegelman, Donna, Aboud, Said, Duggan, Christopher, Danaei, Goodarz, Fawzi, Wafaie W.·2014·JAIDS Journal of Acquired Immune Deficiency Syndromes
DOI 10.1097/qai.0000000000000375PMC PMC4251912
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Abstract

INTRODUCTION: HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age. METHODS: HIV-infected pregnant Tanzanian women recruited into the study were randomly assigned to daily multivitamins (B complex, C, and E), vitamin A alone, both multivitamins and vitamin A, or placebo. Women received malaria prophylaxis during pregnancy and were followed monthly during the prenatal and postpartum periods. Malaria was defined in 2 ways: presumptive diagnosis based on a physician's or nurse's clinical judgment, which in many cases led to laboratory investigations, and periodic examination of blood smears for malaria parasites. RESULTS: Multivitamin supplementation compared with no multivitamins significantly lowered women's risk of presumptively diagnosed clinical malaria (relative risk: 0.78, 95% confidence interval: 0.67 to 0.92), although multivitamins increased their risk of any malaria parasitemia (relative risk: 1.24, 95% confidence interval: 1.02 to 1.50). Vitamin A supplementation did not change malaria incidence during the study. CONCLUSIONS: Multivitamin supplements have been previously shown to reduce HIV disease progression among HIV-infected women, and consistent with that, these supplements protected against development of symptomatic malaria. The clinical significance of increased risk of malaria parasitemia among supplemented women deserves further research, however. Preventive measures for malaria are warranted as part of an integrated approach to the care of HIV-infected individuals exposed to malaria.

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Metadata

Authors
Olofin, I. O., Spiegelman, D., Aboud, S., Duggan, C., Danaei, G., & Fawzi, W. W.
Affiliations
  • Boston Children's Hospital (US)
  • Harvard University (US)
  • Muhimbili University of Health and Allied Sciences (TZ)
Corresponding author
  • Olofin, Ibironke O.
  • Spiegelman, Donna
  • Danaei, Goodarz
  • Fawzi, Wafaie W.
ORCID
Venue
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-12-01
Volume
67
Issue
Supplement 4
Pages
S173-S178
ISSN
1525-4135 (ISSN-L)
DOI
10.1097/qai.0000000000000375
PMC
PMC4251912
OpenAlex
W2134137086
Cited by
30
References
39
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 1
FWCI
2.65
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • IHI Repository (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • Muhimbili University of Health and Allied Sciences
  • University of Health and Allied Sciences
  • National Institute of Diabetes and Digestive and Kidney Diseases (K24DK104676, P30DK040561)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD058795)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
Keywords
multivitamin supplementation, vitamin A supplementation, malaria incidence, HIV infection, pregnant women, malaria parasitaemia, malaria prophylaxis, B vitamins, vitamin C, vitamin E
MeSH terms
Adolescent, Adult, Ascorbic Acid, Female, Humans, Middle Aged, Postnatal Care, Pregnancy, Pregnancy Complications, Infectious, Prenatal Care, Tanzania, Vitamin A, Vitamin B Complex, Vitamin E, HIV Infections, Comorbidity, Incidence, Malaria, Falciparum, Dietary Supplements, Young Adult

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