Cited by 38Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Inflammation, high-density lipoprotein and cardiovascular dysfunction

Haas, Michael J, Mooradian, Arshag D·2011·Current Opinion in Infectious Diseases

Abstract

PURPOSE OF REVIEW: This review describes the evidence that supports the hypothesis that high-density lipoprotein (HDL) is atheroprotective due to its antiinflammatory effects and benefits on vascular health. RECENT FINDINGS: Recent investigations have shown that HDL may inhibit atherosclerosis by promoting healthy endothelial function and by limiting or inhibiting the activation of macrophage and other immune cells. Receptors for HDL clearly regulate immune system function as well as cellular stress. Recent studies also suggest that participation of HDL in the process of reverse cholesterol transport may inhibit growth factor and cytokine receptor signaling by depleting cholesterol from lipid rafts. However, inflammation can also be associated with circulating dysfunctional HDL, which often possesses both prooxidative and proinflammatory properties. SUMMARY: These studies suggest that HDL-based therapeutics have potential in treating both acute and chronic conditions associated with inflammation. These studies also reveal several other pathways that may be targeted for therapeutic drug development.

Integrity signals

Registry

Crossref · 10.1097/qco.0b013e328344b724

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71 of 71 references verified0 citation errors · 0 not checkable

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  • HDL can protect against atherosclerosis by multiple mechanisms, including the ability to efflux cholesterol from endothelial macrophages (macrophage reverse cholesterol transport), or through anti-inflammatory, antioxidative and antiapoptotic pathways.

    “HDL can protect against atherosclerosis by multiple mechanisms, including the ability to efflux cholesterol from endothelial macrophages (macrophage reverse cholesterol transport)43, or through anti-inflammatory44, antioxidative45 and antiapoptotic46 pathways.”

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Authors
Haas, M. J., & Mooradian, A. D.
Affiliations
University of Florida (US)
Corresponding author
Haas, Michael J
Venue
Current Opinion in Infectious Diseases
Published
2011-06
Volume
24
Issue
3
Pages
265-272
ISSN
0951-7375 (ISSN-L)
OpenAlex
W2327064388
Cited by
38
References
71
Citations by year
2025: 2 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 8 · 2012: 13
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
high-density lipoprotein, inflammation, atherosclerosis, endothelial function, macrophage activation, HDL receptor, reverse cholesterol transport, lipid rafts, HDL dysfunction, cardiovascular dysfunction
MeSH terms
Anti-Inflammatory Agents, Cardiovascular Diseases, Coronary Artery Disease, Humans, Inflammation, Lipoproteins, HDL

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