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Updated Guideline on Treatment and Management of Craniosynostosis
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Contents CHAPTER 1. INTRODUCTION The first version of the Dutch guideline for care and treatment of patients with craniosynostosis was established in 2010 and published in 2015.1 The Dutch Society for Plastic and Reconstructive Surgery initiated the revision of this guideline, to update it according to the most recent scientific literature. This second version has been approved by all participating societies in 2020. All chapters from the previous version were revised and new topics on prenatal detection and speech and language development were introduced. REFERENCES 1. Mathijssen IMJ. Guideline for care of patients with the diagnoses of craniosynostosis: Working group on craniosynostosis. J Craniofac Surg 2015:26:1735-1807. CHAPTER 2. METHODOLOGY FOR GUIDELINE DEVELOPMENT Input of Patient Perspective The patient perspective was taken into account by asking the Patient Federation Netherlands for written input on bottlenecks and points for attention in the preparatory phase. They forwarded the request for the submission of bottlenecks to LAPOSA and Stichting Kind en Ziekenhuis (Child and Hospital Foundation). No bottlenecks were submitted. In addition, the chair of LAPOSA had a seat in the working group. During the comment phase, the draft guideline was also presented to the Patient Federation Netherlands, LAPOSA and Foundation Child and Hospital. For information: A focus group meeting had been organized during the development of the guideline in 2010 (see Appendix 1, https://links.lww.com/SCS/B832). This report is still valid. Method Employed by the Working Group Procedure in 2010 The content of this guideline is based on evidence from published scientific research. Relevant articles were identified using systematic searches in Medline, Embase, and the Cochrane Library. Existing guidelines were specifically searched for in online accessible (international and national guideline clearinghouses). Searches were limited to the Dutch, English and French languages. In addition, articles were extracted from reference lists of relevant literature. This resulted for several basic questions in additional articles. Care for children with craniosynostosis was introduced in the late 1960 s, and consequently the English literature from those years onwards was included. Searches were performed until 1 December 2009 and articles available as “Epub ahead of publication” at that date were included as well. Regarding all basic questions, patient categories were defined in a uniform way. The following search terms were used: craniofacial, craniosynostosis combined with: genetics, hydrocephalus, Chiari, cerebral pressure, otitis, hearing, vision, psychology, anesthesia, complications, infection, development, growth, maxilla, mandible, distraction, osteotomy, Fort, midface, RED, halo, monobloc, facial bipartition, median fasciotomy, hypertelorism. The complete search strategies are available on request. Relevant articles extracted from reference lists of retrieved literature and several relevant publications until 1 November 2009 were included as well. Ongoing research was left out of consideration. Under the headings Summary of the literature / Conclusions only published studies / guidelines are discussed. Case reports and letters were excluded, unless they reported a complication. The selected articles were assessed on methodological quality graded by level of evidence according to the standard classification: see Table 1. After selection, those articles remained that are listed to underpin the various conclusions. The articles are assessed under the heading ‘Summary of the literature’. Next, the scientific evidence was briefly summarized in a ‘Conclusion’. The main literature on which a conclusion is based was mentioned as well, including the level of evidence (see Table 2). Other aspects than scientific evidence may be relevant to making a recommendation as well, such as patient preferences (derived from the results of the focus group sessions or relevant literature on the patient perspective), costs, availability, or organizational aspects. These kinds of aspects, provided they have not been subject of research, were mentioned under the heading ‘Considerations’. The experience and the opinion of the working group members have been key to the other considerations. The ‘Recommendation’ results from the combination of the available evidence and the other considerations. Procedure in 2017/2018 AGREE This guideline has been revised in accordance with the requirements according to the report Medical Specialist Guidelines 2.0 of the Advisory Committee on Guidelines of the Council for Quality (www.kwaliteitskoepel.nl). This report is based on the AGREE II instrument (Appraisal of Guidelines for Research & Evaluation II) (www.agreecollaboration.org), which is an internationally widely accepted instrument, and on ’guidelines for guideline’ for assessing the quality of guidelines (www.cvz.nl). Bottleneck Analysis During the preparator
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“Surgical approaches have evolved from simple linear craniectomies to more complex cranial vault reconstructions (CVR) as well as minimal invasive approaches, highlighting continued efforts to refine treatment approaches for this complex condition [1, 6].”
From Developments in diagnostic and surgical techniques in children with sagittal suture craniosynostosis: a systematic review spanning the last 30 years (2025) · cites this paper as [6]
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“The effective use of these technologies still requires specialized expertise for accurate interpretation and further appropriate treatment recommendations based on the latest research findings [2, 6].”
From Developments in diagnostic and surgical techniques in children with sagittal suture craniosynostosis: a systematic review spanning the last 30 years (2025) · cites this paper as [6]
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Self-citationHearing loss in syndromic craniosynostoses: Otologic manifestations and clinical findings
Agochukwu, N. B., Solomon, B. D., & Muenke, M. (2014) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2014.09.019 · Cited by 45
Anolik, R. A., Allori, A., Pourtaheri, N., Rogers, G., & Marcus, J. (2016) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0000000000002052 · Cited by 44
Facial Growth in Patients with Apert and Crouzon Syndromes Compared to Normal Children
Reitsma, J., Ongkosuwito, E., Buschang, P., & Prahl-Andersen, B. (2012) · The Cleft Palate-Craniofacial Journal · doi:10.1597/10-021 · Cited by 44
Eley, K., Johnson, D. W., Wilkie, A. O., Jayamohan, J., Richards, P., & Wall, S. (2012) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e318267d5ae · Cited by 43
Luna-Paredes, C., Antón-Pacheco, J., Hernández, G. G., Gimeno, A. M., García, A. R. R., & Recuero, I. I. G. (2012) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2012.08.020 · Cited by 42
Adenotonsillectomy for Sleep-Disordered Breathing in Children With Syndromic Craniosynostosis
Amonoo-Kuofi, K., Phillips, S., Randhawa, P., Lane, R., Wyatt, M., & Leighton, S. (2009) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0b013e3181bd2c9a · Cited by 42
Czerwiński, M., Kolar, J. C., & Fearon, J. (2011) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e3182268ca6 · Cited by 40
Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations.
Jadico, S. K., Huebner, A., McDonald-McGinn, D., Zackai, E., & Young, T. (2006) · Journal of AAPOS · doi:10.1016/j.jaapos.2006.06.008 · Cited by 40
Health-related problems and quality of life in patients with syndromic and complex craniosynostosis
de Jong, T., Maliepaard, M., Bannink, N., Raat, H., & Mathijssen, I. (2012) · Child's Nervous System · doi:10.1007/s00381-012-1681-4 · Cited by 39
Self-citationOphthalmic findings in apert syndrome prior to craniofacial surgery.
Khong, J., Anderson, P., Gray, T., Hammerton, M., Selva, D., & David, D. (2006) · American journal of ophthalmology-glaucoma · doi:10.1016/j.ajo.2006.02.046 · Cited by 39
Complications in 54 Frontofacial Distraction Procedures in Patients With Syndromic Craniosynostosis
Goldstein, J., Paliga, J. T., Taylor, J. A., & Bartlett, S. (2015) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0000000000001320 · Cited by 38
Driessen, C., van Veelen, M. V., Lequin, M., Joosten, K., & Mathijssen, I. (2012) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e31825dc1f1 · Cited by 38
Self-citationReformation of the sagittal suture following surgery for isolated sagittal craniosynostosis.
Agrawal, D., Steinbok, P., & Cochrane, D. (2006) · Journal of Neurosurgery · doi:10.3171/ped.2006.105.2.115 · Cited by 38
Rijken, B., den Ottelander, B. D., van Veelen, M. V., Lequin, M., & Mathijssen, I. (2015) · Neurosurgical Focus · doi:10.3171/2015.2.focus14846 · Cited by 37
Self-citationScott, W., Fearon, J., Swift, D., & Sacco, D. (2013) · Journal of Neurosurgery: Pediatrics · doi:10.3171/2013.4.peds12463 · Cited by 36
Behavioral Adjustment of Toddler and Preschool-Aged Children with Single-Suture Craniosynostosis
Kapp-Simon, K., Collett, B., Barr-Schinzel, M. A., Cradock, M., Buono, L., Pietila, K. E., & Speltz, M. L. (2012) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e31825dc18b · Cited by 36
Pattern of Closure of Skull Base Synchondroses in Crouzon Syndrome.
Coll, G., Sakka, L., Botella, C., Pham-Dang, N., Collet, C., Zérah, M., Arnaud, É., & Rocco, F. D. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2017.09.208 · Cited by 36
Seruya, M., Tan, S. Y., Wray, A. C., Penington, A. J., Greensmith, A. L., Holmes, A. D., & Chong, D. K. (2013) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e31829f4b3d · Cited by 35
Fischer, S., Maltese, G., Tarnow, P., Wikberg, E., Bernhardt, P., & Kölby, L. (2016) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0000000000002519 · Cited by 35
Intracranial hypertension after surgical correction for craniosynostosis: a systematic review.
Christian, E., Imahiyerobo, T. A., Nallapa, S., Urata, M., McComb, J., & Krieger, M. D. (2015) · Neurosurgical Focus · doi:10.3171/2015.2.focus14853 · Cited by 35
Jadico, S. K., Young, D., Huebner, A., Edmond, J., Pollock, A., McDonald-McGinn, D., Li, Y.-J., Zackai, E., & Young, T. (2006) · Journal of AAPOS · doi:10.1016/j.jaapos.2006.07.012 · Cited by 35
Delayed synostoses of uninvolved sutures after surgical treatment of nonsyndromic craniosynostosis
Yarbrough, C. K., Smyth, M. D., Holekamp, T. F., Ranalli, N. J., Huang, A. H., Patel, K. B., Kane, A. A., & Woo, A. S. (2014) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e3182a75102 · Cited by 35
van Veelen, M. V., Jippes, M., Carolina, J. A., de Rooi, J. D., Dirven, C., Adrichem, L. V. V., & Mathijssen, I. (2016) · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · doi:10.1016/j.jcms.2016.07.029 · Cited by 34
Self-citationSpring-assisted surgery in the treatment of sagittal synostosis: A systematic review
Maltese, G., Fischer, S., Strandell, A., Tarnow, P., & Kölby, L. (2015) · Journal of Plastic Surgery and Hand Surgery · doi:10.3109/2000656x.2014.981268 · Cited by 34
Ophthalmic Findings in Children With Nonsyndromic Craniosynostosis Treated by Expansion Cranioplasty
Chung, S.-A., Yun, I., Moon, J., & Lee, J. (2015) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0000000000001238 · Cited by 34
Optical coherence tomography: a quantitative tool to screen for papilledema in craniosynostosis
Driessen, C., Eveleens, J. R. J., Bleyen, I., van Veelen, M. V., Joosten, K., & Mathijssen, I. (2014) · Child's Nervous System · doi:10.1007/s00381-014-2376-9 · Cited by 34
Self-citationMetopic “ridge” vs. “craniosynostosis”: Quantifying severity with 3D curvature analysis
Cho, M., Kane, A. A., Seaward, J. R., & Hallac, R. R. (2016) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2016.06.019 · Cited by 34
Ophthalmologic Outcomes Following Fronto-Orbital Advancement for Unicoronal Craniosynostosis
Gencarelli, J., Murphy, A., Samargandi, O. A., & Bezuhly, M. (2016) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0000000000003085 · Cited by 33
Frontofacial Advancement by Distraction Osteogenesis: A Long-Term Review
Gwanmesia, I., Jeelani, O., Hayward, R., & Dunaway, D. (2015) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0000000000001115 · Cited by 33
Palatal and Oral Manifestations of Muenke Syndrome (FGFR3-Related Craniosynostosis)
Agochukwu, N. B., Solomon, B. D., Doherty, E. S., & Muenke, M. (2012) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e31824db8bb · Cited by 33
Endoscopically assisted craniosynostosis surgery (EACS): The craniofacial team Nijmegen experience
Delye, H., Arts, S., Borstlap, W. A., Blok, L. M., Driessen, J. J., Meulstee, J. W., Maal, T., & van Lindert, E. J. (2016) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2016.05.014 · Cited by 30
Memory and Response Inhibition in Young Children with Single-Suture Craniosynostosis
Toth, K., Collett, B. R., Kapp‐Simon, K. A., Cloonan, Y. K., Gaither, R., Cradock, M. M., Buono, L. A., Cunningham, M. L., Dawson, G., Starr, J. R., et al. (2008) · Child Neuropsychology · doi:10.1080/09297040701594888 · Cited by 30
Benign Radiographic Coronal Synostosis After Sagittal Synostosis Repair
Kuang, A. A., Jenq, T., Didier, R., Moneta, L. B., Bardo, D., & Selden, N. (2013) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0b013e31828dcf24 · Cited by 29
Dental agenesis patterns of permanent teeth in Apert syndrome.
Stavropoulos, D., Bartzela, T., Bronkhorst, E., Mohlin, B., & Hagberg, C. (2011) · European Journal of Oral Sciences · doi:10.1111/j.1600-0722.2011.00821.x · Cited by 28
Dental Maturation in Children with the Syndrome of Crouzon and Apert
Reitsma, J. H., Balk-Leurs, I. H., Ongkosuwito, E. M., Wattel, E., & Prahl‐Andersen, B. (2013) · The Cleft Palate-Craniofacial Journal · doi:10.1597/13-071 · Cited by 28
Adenotonsillectomy for obstructive sleep apnea in children.
González, R. (2011) · The American Journal of Nursing · doi:10.1097/01.naj.0000403357.36435.fb · Cited by 27
Use of Ambulatory Polysomnography in Children With Syndromic Craniosynostosis
Bannink, N., Mathijssen, I., & Joosten, K. (2010) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0b013e3181ec69a5 · Cited by 27
Self-citationvan Veelen, M.-L. C., Mihajlović, D., Dammers, R., Lingsma, H., van Adrichem, L. N. A., & Mathijssen, I. M. J. (2015) · Journal of Neurosurgery: Pediatrics · doi:10.3171/2014.12.peds14260 · Cited by 27
Self-citationThe Management of Obstructive Sleep Apnea in Syndromic Craniosynostosis
Nash, R., Possamai, V., Manjaly, J., & Wyatt, M. (2015) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0000000000002097 · Cited by 26
Vasco, G., Baranello, G., Ricci, D., Salerni, A., Tamburrini, G., Amante, R., Dickmann, A., di Rocco, C., Velardi, F., & Mercuri, E. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2007.128421 · Cited by 26
The Dental Health and Caries-Related Microflora in Children With Craniosynostosis
Mustafa, D., Lucas, V. S., Junod, P., Evans, R. D., Mason, C., & ROBERTS, G. J. (2001) · The Cleft Palate-Craniofacial Journal · doi:10.1597/1545-1569(2001)038 · Cited by 26
Dagi, L. R., Tiedemann, L. M., Heidary, G., Robson, C., Hall, A. M., & Zurakowski, D. (2014) · Journal of AAPOS · doi:10.1016/j.jaapos.2014.07.177 · Cited by 23
Volumetric Analysis of Cranial Vault Distraction for Cephalocranial Disproportion
Deschamps-Braly, J. C., Hettinger, P., Amm, C. E., & Denny, A. (2012) · Pediatric Neurosurgery · doi:10.1159/000337873 · Cited by 23
What Are the Effects of Metopic Synostosis on Visual Function?
Macintosh, C., Wells, R., Johnson, D. W., & Wall, S. (2011) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0b013e31821c6a64 · Cited by 23
Effects of a Child With a Craniofacial Anomaly on Stability of the Parental Relationship
John, D. S., Pai, L., Belfer, M., & Mulliken, J. (2003) · The Journal of craniofacial surgery (Print) · doi:10.1097/00001665-200309000-00019 · Cited by 23
Spruijt, B., Mathijssen, I., Bredero-Boelhouwer, H., Cherian, P., Corel, L., van Veelen, M. V., Hayward, R., Tasker, R., & Joosten, K. (2016) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0000000000002741 · Cited by 22
Self-citationA longitudinal study of dental arch morphology in children with the syndrome of Crouzon or Apert.
Reitsma, J., Elmi, P., Ongkosuwito, E., Buschang, P., & Prahl-Andersen, B. (2013) · European Journal of Oral Sciences · doi:10.1111/eos.12051 · Cited by 21
Incidence of Amblyopia and Its Risk Factors in Children with Isolated Metopic Craniosynostosis
Nguyen, T. B., Shock, L. A., Missoi, T. G., & Muzaffar, A. (2014) · The Cleft Palate-Craniofacial Journal · doi:10.1597/14-212 · Cited by 20
Differential Effects of FGFR2 Mutation in Ophthalmic Findings in Apert Syndrome
Khong, J., Anderson, P., Hammerton, M., Roscioli, T., Selva, D., & David, D. (2007) · The Journal of craniofacial surgery (Print) · doi:10.1097/01.scs.0000249358.74343.70 · Cited by 20
Determining the fate of cranial sutures after surgical correction of non-syndromic craniosynostosis.
Kim, S. Y., Shin, H., & Lim, S.-Y. (2017) · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · doi:10.1016/j.jcms.2017.08.009 · Cited by 18
Sharma, N., Greenwell, T. H., Hammerton, M., David, D., Selva, D., & Anderson, P. (2016) · Journal of AAPOS · doi:10.1016/j.jaapos.2016.04.007 · Cited by 18
Cradock, M. M., Gray, K. E., Kapp‐Simon, K. A., Collett, B. R., Buono, L. A., & Speltz, M. L. (2015) · Child s Nervous System · doi:10.1007/s00381-015-2671-0 · Cited by 18
Caterson, E., Shetye, P., Grayson, B., & Mccarthy, J. (2013) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e31829f4b11 · Cited by 16
Does central sleep apnea occur in children with syndromic craniosynostosis?
Driessen, C., Mathijssen, I., de Groot, M., & Joosten, K. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.03.017 · Cited by 16
Self-citationSleep apnoea in syndromic craniosynostosis occurs independent of hindbrain herniation
Driessen, C., Joosten, K., Florisson, J., Lequin, M., van Veelen, M. V., Dammers, R., Bredero-Boelhouwer, H., Tasker, R., & Mathijssen, I. (2012) · Child's Nervous System · doi:10.1007/s00381-012-1922-6 · Cited by 16
Self-citationFujimoto, T., Imai, K., Matsumoto, H., Sakamoto, H., & Nakano, T. (2011) · The Journal of craniofacial surgery (Print) · doi:10.1097/scs.0b013e31822e5d15 · Cited by 15
Mandibular Asymmetry in Patients with the Crouzon or Apert Syndrome
Elmi, P., Reitsma, J., Buschang, P., Wolvius, E., & Ongkosuwito, E. (2015) · The Cleft Palate-Craniofacial Journal · doi:10.1597/13-143 · Cited by 14
Patterns of Tooth Agenesis in Patients with Crouzon or Apert Syndrome
Reitsma, J., Ongkosuwito, E., van Wijk, A., & Prahl-Andersen, B. (2014) · The Cleft Palate-Craniofacial Journal · doi:10.1597/12-180 · Cited by 13
The dental development in patients with Aperts syndrome.
Woods, E., Parekh, S., Evans, R., Moles, D., & Gill, D. (2015) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.12114 · Cited by 11
Audiologic Findings in Saethre-Chotzen Syndrome
Rosen, H., Andrews, B., Meara, J. G., Stoler, J., Mulliken, J., & Rogers, G. (2011) · Plastic and Reconstructive Surgery · doi:10.1097/prs.0b013e31820cf16a · Cited by 10
Papilledema in unicoronal synostosis: a rare finding.
van de Beeten, S. D. C., Cornelissen, M., van Seeters, R. M., van Veelen, M. V., Versnel, S., Loudon, S., & Mathijssen, I. (2019) · Journal of Neurosurgery: Pediatrics · doi:10.3171/2019.3.peds18624 · Cited by 9
Self-citationKnudsen, E., Maltese, G., Tarnow, P., Tovetjärn, R., & Kölby, L. (2012) · Journal of Plastic Surgery and Hand Surgery · doi:10.3109/2000656x.2012.676555 · Cited by 9
Gray, K. E., Kapp-Simon, K., Starr, J. R., Collett, B., Wallace, E. R., & Speltz, M. L. (2014) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12643 · Cited by 8
Insight into the Pathophysiologic Mechanisms behind Cognitive Dysfunction in Trigonocephaly
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Family-centred care during midface advancement with a rigid external device: what do families need?
Bredero-Boelhouwer, H., Joosten, K., der Hoek, M. V. V.-V., & Mathijssen, I. (2013) · Journal of Plastic, Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2013.04.022 · Cited by 5
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Non-syndromic craniosynostosis
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“The development of a fused metopic suture in the first year of life without any morphological cranial deformity is referred to as metopic ridging and is distinct from trigonocephaly 13,127 .”
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Metadata
- Authors
- Mathijssen, I. M. J.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Mathijssen, Irene M.J.
- Venue
- Journal of Craniofacial Surgery
- Published
- 2020-11-04
- Volume
- 32
- Issue
- 1
- Pages
- 371-450
- ISSN
- 1049-2275 (ISSN-L)
- 1536-3732
- PMC
- PMC7769187
- OpenAlex
- W3096934129
- Cited by
- 140
- References
- 159
- Citations by year
- 2026: 29 · 2025: 31 · 2024: 29 · 2023: 29 · 2022: 14 · 2021: 7 · 2020: 1
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Craniofacial Surgery (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- Stichting Kwaliteitsgelden Medisch Specialisten
- Topics
- Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
- Health Sciences › Medicine › Surgery › Pectus Deformity Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Reconstructive Facial Surgery Techniques
- Keywords
- prenatal diagnosis, speech and language development, pediatric neurosurgery, craniofacial surgery, patient perspectives, guideline development, multidisciplinary care
- MeSH terms
- Craniosynostoses, Humans
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