The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Randomized Pilot Trial of Bariatric Surgery Versus Intensive Medical Weight Management on Diabetes Remission in Type 2 Diabetic Patients Who Do NOT Meet NIH Criteria for Surgery and the Role of Soluble RAGE as a Novel Biomarker of Success
Open accessAbstract
In Brief Objective: To compare bariatric surgery versus intensive medical weight management (MWM) in patients with type 2 diabetes mellitus (T2DM) who do not meet current National Institutes of Health criteria for bariatric surgery and to assess whether the soluble form of receptor for advanced glycation end products (sRAGE) is a biomarker to identify patients most likely to benefit from surgery. Background: There are few studies comparing surgery to MWM for patients with T2DM and BMI less than 35. Methods: Fifty-seven patients with T2DM and BMI 30 to 35, who otherwise met the criteria for bariatric surgery were randomized to MWM versus surgery (bypass, sleeve or band, based on patient preference). The primary outcomes assessed at 6 months were change in homeostatic model of insulin resistance (HOMA-IR) and diabetes remission. Secondary outcomes included changes in HbA1c, weight, and sRAGE. Results: The surgery group had improved HOMA-IR (−4.6 vs +1.6; P = 0.0004) and higher diabetes remission (65% vs 0%, P < 0.0001) than the MWM group at 6 months. Compared to MWM, the surgery group had lower HbA1c (6.2 vs 7.8, P = 0.002), lower fasting glucose (99.5 vs 157; P = 0.0068), and fewer T2DM medication requirements (20% vs 88%; P < 0.0001) at 6 months. The surgery group lost more weight (7. vs 1.0 BMI decrease, P < 0.0001). Higher baseline sRAGE was associated with better weight loss outcomes (r = −0.641; P = 0.046). There were no mortalities. Conclusions: Surgery was very effective short-term in patients with T2DM and BMI 30 to 35. Baseline sRAGE may predict patients most likely to benefit from surgery. These findings need to be confirmed with larger studies. ClinicalTrials.gov ID: NCT01423877 This pilot randomized trial comparing bariatric surgery to medical weight management in patients with type 2 diabetes and BMI 30 to 35 found that surgery was very effective in improving insulin resistance and inducing diabetes remission at 6 months. We also found that sRAGE may be a good biomarker to identify which patients benefit most from surgery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A short-term follow-up randomized trial examining patients with T2D demonstrated significantly improved remission of diabetes and weight loss in those individuals undergoing MBS compared with medical weight management [35].”
In the citing paper
“A RCT performed in a mixed population (RYGB, sleeve gastrectomy, banding) reported a weighted mean difference (WMD) of 53% (95% confidence interval, CI, 42% to 63%) excess weight loss (EWL) compared to non-operative management [34].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis
Buchwald, H., Estok, R., Fahrbach, K., Banel, D., Jensen, M. D., Pories, W. J., Bantle, J. P., & Sledge, I. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.041 · Cited by 2,551
Boutron, I., Moher, D., Altman, D. G., Schulz, K. F., Ravaud, P., & for the CONSORT Group* (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-4-200802190-00008 · Cited by 2,292
Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
Schauer, P. R., Kashyap, S. R., Wolski, K., Brethauer, S. A., Kirwan, J. P., Pothier, C. E., Thomas, S., Abood, B., Nissen, S. E., & Bhatt, D. L. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200225 · Cited by 2,164
Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
Mingrone, G., Panunzi, S., De Gaetano, A., Guidone, C., Iaconelli, A., Leccesi, L., Nanni, G., Pomp, A., Castagneto, M., Ghirlanda, G., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200111 · Cited by 1,791
Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
Selvin, E., Steffes, M. W., Zhu, H., Matsushita, K., Wagenknecht, L., Pankow, J., Coresh, J., & Brancati, F. L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908359 · Cited by 1,544
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522
Dixon, J. B., O’Brien, P. E., Playfair, J., Chapman, L., Schachter, L. M., Skinner, S., Proietto, J., Bailey, M., & Anderson, M. (2008) · JAMA · doi:10.1001/jama.299.3.316 · Cited by 1,434
Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
Wadden, T. A., Berkowitz, R. I., Womble, L. G., Sarwer, D. B., Phelan, S., Cato, R. K., Hesson, L. A., Osei, S. Y., Kaplan, R., & Stunkard, A. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050156 · Cited by 794
Cited by
Sorted by citations
Items 101–123 of 123
Shtarkman, A., Drago, L., & Parikh, M. (2016) · AADE in Practice · doi:10.1177/2325160316666561
Self-citationNahle, A. (2016) · TSpace (University of Toronto)
Alkaff, F. F., Nugraha, R. A., Jonatan, M., & Wati, S. (2018) · Biomolecular and Health Science Journal · doi:10.20473/bhsj.v1i1.8192
Bariatric surgery in diabetes Mellitus type 2: predictors of remission, outcome and guidelines.
Ferreira, A. M. D. S. L. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/2bjp-fh97
Peçanha, O. J. D. S., da Silva, C. R. L., Louro, T. Q., Machado, D. A., Avellar, J. G. N. D. S., & da Silva, R. C. L. (2019) · Cogitare Enfermagem · doi:10.5380/ce.v24i0.64034
Gastric Bypass for Type 2 Diabetes Mellitus on BMI < 35
Filho, A. C., Teixeira, A. F., Grecco, E., de Quadros, L. G., Neto, M. G., & de Souza, T. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-28803-7_47
Metabolic Surgery; Indications and Outcomes
Castagneto‐Gissey, L., Casella-Mariolo, J. R., & Mingrone, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65824-5
The metabolic effects of surgery in type 2 diabetes
Özgüç, H. (2021) · Annals of Laparoscopic and Endoscopic Surgery · doi:10.21037/ales-19-248
Wisbach, G. G. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.02.014 · Cited by 10
Andrade, V. B. P. K., Andreoli, C. V., Ejnisman, B., Pochini, A. D. C., & Biruel, E. P. (2021) · Brazilian Journal of Health Review · doi:10.34119/bjhrv4n2-444
Sudlow, A. C., le Roux, C. W., & Pournaras, D. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-54064-7_100-1
Anästhesie in der Viszeralchirurgie
Brack, A., Kaspar, M., & Welte, M. (2016) · Springer eBooks · doi:10.1007/978-3-662-45539-5_78-1
Anästhesie in der Viszeralchirurgie
Brack, A., Kaspar, M., & Welte, M. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-54507-2_78
Carette, C., Poghosyan, T., & Czernichow, S. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76753-1.00095-3
(2015) · British journal of surgery · doi:10.1002/bjs.9801
Pedron, F. F., de Moura, D. S., Calcing, A., Patias, L. D., Alvarez, G. D. C., Machado, A. C. D. A., & de Moraes, C. M. B. (2022) · Brazilian Journal of Health Review · doi:10.34119/bjhrv5n6-049
Bariatric surgery effects on glycemic control and diabetes mellitus remission: A meta-analysis
Mirghani, H. O., Alamrani, B. A., Algabri, M. O., Alatawi, M. S., Alasmari, M. S., Alsharif, A., Alqahtani, F., Albalawi, M., Alamrani, F. O., Albalawi, A. E., et al. (2022) · Medical Science · doi:10.54905/disssi/v26i130/ms510e2603
Hanna, A. C. L., Costa, R. V., Rodrigues, R. B. D. O., Souza, T. P. D., Abreu, L. F. D., Oliveira, R. T. D., Neto, R. M. C., Brito, L. F. T., Vuolo, F. H. P., Chaves, M. V. D. M., et al. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n4-069
Weight Management and Metabolic Surgery
Sudlow, A. C., Pournaras, D. J., & le Roux, C. W. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch38
Diabetes After Bariatric Surgery
Bello-Ramos, J. C., Rizo, I. M., & Alexanian, S. M. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-44648-1_22
Bariatric Surgery Indications in the 2020s
Hill, C. E., Shikora, S. A., & Kothari, S. N. (2024) · Springer eBooks · doi:10.1007/978-3-031-72309-4_4
Leyaro, B. J., Howie, L., Ali, A., & Carragher, R. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01956-6 · Cited by 1
Metadata
- Authors
- Parikh, M., Chung, M., Sheth, S., McMacken, M., Zahra, T., Saunders, J. K., Ude-Welcome, A., Dunn, V., Ogedegbe, G., Schmidt, A. M., & Pachter, H. L.
- Affiliations
- Lincoln Medical Center (US)
- New York City Health and Hospitals Corporation (US)
- Bellevue Hospital Center (US)
- Corresponding author
- Parikh, Manish
- Chung, Mimi
- Sheth, Sheetal
- Saunders, John K.
- Pachter, H. Leon
- ORCID
- Venue
- Annals of Surgery
- Published
- 2014-10
- Volume
- 260
- Issue
- 4
- Pages
- 617-624
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC4691842
- OpenAlex
- W2334320614
- Cited by
- 123
- References
- 27
- Citations by year
- 2025: 8 · 2024: 5 · 2023: 19 · 2022: 8 · 2021: 13 · 2020: 16 · 2019: 11 · 2018: 10 · 2017: 8 · 2016: 19 · 2015: 6
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agency for Healthcare Research and Quality (K12HS019473)
- National Center for Research Resources (UL1RR029893, KL2RR029891)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- bariatric surgery, type 2 diabetes, diabetes remission, soluble receptor for advanced glycation end products, treatment response biomarkers, insulin resistance, HOMA-IR, HbA1c, weight loss, sleeve gastrectomy, gastric bypass, gastric band, obesity
- MeSH terms
- Receptor for Advanced Glycation End Products, Adult, Counseling, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Pilot Projects, Receptors, Immunologic, Remission Induction, Biomarkers, Weight Loss, Body Mass Index, Glycation End Products, Advanced, Bariatric Surgery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
