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Cited by 580Appendicitis Diagnosis and ManagementIntraperitoneal and Appendiceal MalignanciesGastrointestinal disorders and treatments

The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies

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Ferris, Mollie, Quan, Samuel, Kaplan, Belle S., Molodecky, Natalie, Ball, Chad G., Chernoff, Greg W., Bhala, Nij, Ghosh, Subrata +3 more·2017·Annals of Surgery
DOI 10.1097/sla.0000000000002188
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Abstract

OBJECTIVE: We compared the incidence of appendicitis or appendectomy across the world and evaluated temporal trends. SUMMARY BACKGROUND DATA: Population-based studies reported the incidence of appendicitis. METHODS: We searched MEDLINE and EMBASE databases for population-based studies reporting the incidence of appendicitis or appendectomy. Time trends were explored using Poisson regression and reported as annual percent change (APC) with 95% confidence intervals (CI). APC were stratified by time periods and pooled using random effects models. Incidence since 2000 was pooled for regions in the Western world. RESULTS: The search retrieved 10,247 citations with 120 studies reporting on the incidence of appendicitis or appendectomy. During the 21st century the pooled incidence of appendicitis or appendectomy (in per 100,000 person-years) was 100 (95% CI: 91, 110) in Northern America, and the estimated number of cases in 2015 was 378,614. The pooled incidence ranged from 105 in Eastern Europe to 151 in Western Europe. In Western countries, the incidence of appendectomy steadily decreased since 1990 (APC after 1989=-1.54; 95% CI: -2.22, -0.86), whereas the incidence of appendicitis stabilized (APC=-0.36; 95% CI: -0.97, 0.26) for both perforated (APC=0.95; 95% CI: -0.25, 2.17) and nonperforated appendicitis (APC=0.44; 95% CI: -0.84, 1.73). In the 21st century, the incidence of appendicitis or appendectomy is high in newly industrialized countries in Asia (South Korea pooled: 206), the Middle East (Turkey pooled: 160), and Southern America (Chile: 202). CONCLUSIONS: Appendicitis is a global disease. The incidence of appendicitis is stable in most Western countries. Data from newly industrialized countries is sparse, but suggests that appendicitis is rising rapidly.

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  • The incidence of perforated and nonperforated acute appendicitis and the number of appendectomies in the United States have been decreasing in recent years.

    “In the United States the incidence of perforated and nonperforated acute appendicitis, as well as the number of appendectomies performed has been decreasing in recent years. 8”

    From Increasing incidence of complicated appendicitis during COVID-19 pandemic (2021) · cites this paper as [8]

    The Results (p. 5) report that appendectomy incidence has decreased since 1990 in Northern America, Europe, and Oceania. But they report that the incidence of both perforated and nonperforated appendicitis has been stable, not decreasing. These are regional trends rather than United States–specific findings. (LLM, conf=0.91)

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Research works printed but not linked: 2

  1. [8]8. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA . 2000;283:2008-2012.
  2. [29]29. D'Inca R, Neri L, Daperno M, et al. Poor adherence is associated with impaired quality of life and increased illness intrusiveness in patients with ulcerative colitis and Crohn disease. Digest Liver Dis . 2015;47:e183.

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Authors
Ferris, M., Quan, S., Kaplan, B. S., Molodecky, N., Ball, C. G., Chernoff, G. W., Bhala, N., Ghosh, S., Dixon, E., Ng, S., & Kaplan, G. G.
Affiliations
  • University of Calgary (CA)
  • Queen Elizabeth Hospital Birmingham (GB)
  • Chinese University of Hong Kong (HK)
Corresponding author
  • Ferris, Mollie
  • Quan, Samuel
  • Kaplan, Belle S.
  • Molodecky, Natalie
  • Ghosh, Subrata
  • Kaplan, Gilaad G.
ORCID
Venue
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-08
Volume
266
Issue
2
Pages
237-241
ISSN
0003-4932 (ISSN-L)
DOI
10.1097/sla.0000000000002188
OpenAlex
W2594769351
Cited by
580
References
27
Citations by year
2026: 63 · 2025: 62 · 2024: 82 · 2023: 94 · 2022: 72 · 2021: 87 · 2020: 64 · 2019: 31 · 2018: 23 · 2017: 2
FWCI
41.62
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Annals of Surgery (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
Funders
  • Alberta Innovates
  • Health Canada
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
  • Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
  • Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
Keywords
appendicitis, appendectomy, incidence, temporal trends, global incidence, appendiceal perforation, uncomplicated appendicitis, newly industrializing countries, Western countries, Asia, South America, Middle East
MeSH terms
Africa, Appendectomy, Appendicitis, Asia, Australia, Europe, Humans, Middle East, North America, South America, Global Health, Incidence, Oceania

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