CoChat
Sign Up
Cited by 8

The DOI matches its Crossref record, with a small difference in title or year.

HLA-A Locus is Associated With Sepsis and Septic Shock After Traumatic Injury

Horn, Dara L., Mindrinos, Michael, Anderson, Kirsten, Krishnakumar, Sujatha, Wang, Chunlin, Li, Ming, Hollenbach, Jill, O’Keefe, Grant E.·2022·Annals of Surgery
DOI 10.1097/sla.0000000000003932PMC PMC10060028
Open this paper in CoChat — free account

Abstract

Objective: Determine whether variation in the HLA region is associated with the development of post-traumatic sepsis and septic shock. Background: Sepsis-related deaths remain a major source of mortality after traumatic injury. Genetic characteristics may contribute to susceptibility to adverse outcomes including sepsis and septic shock. Recent advances in next-generation sequencing technology now allow comprehensive genotyping of the HLA region. Methods: White adult trauma patients requiring more than 2 days of mechanical ventilation underwent HLA genotyping, and were followed for the development of sepsis and septic shock. Odds ratios (OR) for the associations between our outcomes and HLA variants were estimated, a correction for multiple comparisons was applied, and significant variants were included in regression models adjusting for potential confounders. Results: A total of 1184 patients were included. Patients were severely injured (median injury severity score 33); 33% developed sepsis, 6% septic shock, and in-hospital mortality was 14%. An amino acid variant (156Q) within the HLA-A peptide-binding groove was associated with greater odds of sepsis [OR 1.50, (1.18–1.89)]. HLA-A ∗ 02:01 was associated with lower odds of septic shock [OR 0.52, (0.32–0.82)]. These associations remained significant after adjusting for potential confounders. Conclusions: This is the first study to apply next-generation sequencing techniques to evaluate associations between immunogenetic factors and post-traumatic sepsis and septic shock. Associations with class I HLA variants are novel as they implicate adaptive immunity in post-traumatic sepsis. These findings are a step towards developing a panel of genetic markers assessing risk of infection-related complications as we move towards more personalized medicine.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/sla.0000000000003932

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 32

  1. Raju, 2017, Immune and metabolic alterations following trauma and sepsis – an overview, Biochim Biophys Acta - Mol Basis Dis, 1863, 2523, 10.1016/j.bbadis.2017.08.008 · DOI
  2. Dombrovskiy, 2007, Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003∗, Crit Care Med, 35, 1244, 10.1097/01.CCM.0000261890.41311.E9 · DOI
  3. Lagu, 2012, Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007, Crit Care Med, 40, 754, 10.1097/CCM.0b013e318232db65 · DOI · Paper page
  4. Ingraham, 2010, The attributable mortality and length of stay of trauma-related complications, Ann Surg, 252, 358, 10.1097/SLA.0b013e3181e623bf · DOI
  5. Kimura, 2010, Immunosuppression following surgical and traumatic injury, Surg Today, 40, 793, 10.1007/s00595-010-4323-z · DOI
  6. Almansa, 2013, Immunological monitoring to prevent and treat sepsis, Crit Care, 17, 109, 10.1186/cc11922 · DOI
  7. Skrupky, 2011, Advances in the management of sepsis and the understanding of key immunologic defects, Anesthesiology, 115, 1349, 10.1097/ALN.0b013e31823422e8 · DOI
  8. Villar, 2004, Bench-to-bedside review: understanding genetic predisposition to sepsis, Crit Care, 8, 180, 10.1186/cc2863 · DOI
  9. Kotb, 2002, An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections, Nat Med, 8, 1398, 10.1038/nm1202-800 · DOI
  10. Parks, 2019, Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus, Genes Immun, 21, 63, 10.1038/s41435-019-0082-z · DOI
  11. Caruso, 1996, Major histocompatibility complex regulation of cytokine production, J Interf Cytokine Res, 16, 983, 10.1089/jir.1996.16.983 · DOI
  12. Aladzsity, 2011, Analysis of the 8.1 ancestral MHC haplotype in severe, pneumonia-related sepsis, Clin Immunol, 139, 282, 10.1016/j.clim.2011.02.013 · DOI
  13. Shalhub, 2009, Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study, XXX, 66, 115
  14. Shankar-Hari, 2016, Developing a new definition and assessing new clinical criteria for septic shock, JAMA, 315, 775, 10.1001/jama.2016.0289 · DOI
  15. Pappas, 2016, Bridging ImmunoGenomic data analysis workflow gaps (BIGDAWG): an integrated case-control analysis pipeline, Hum Immunol, 77, 283, 10.1016/j.humimm.2015.12.006 · DOI
  16. Hollenbach, 2012, Analytical methods for disease association studies with immunogenetic data, Methods Mol Biol, 882, 245, 10.1007/978-1-61779-842-9_14 · DOI
  17. Lagha, 2016, HLA DRB1/DQB1 alleles and DRB1-DQB1 haplotypes and the risk of rheumatoid arthritis in Tunisians: a population-based case-control study, HLA, 88, 100, 10.1111/tan.12855 · DOI
  18. Kuranov, 2014, Behçet's disease in HLA-B ∗ 51 negative Germans and Turks shows association with HLA-Bw4-80I, Arthritis Res Ther, 16, R116, 10.1186/ar4569 · DOI
  19. Stevens, 2016, Brief report: HLA-DRB1, DQA1, and DQB1 in juvenile-onset systemic sclerosis, Arthritis Rheumatol, 68, 2772, 10.1002/art.39765 · DOI
  20. Hershman, 1990, Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient, Br J Surg, 77, 204, 10.1002/bjs.1800770225 · DOI · Paper page
  21. Cheron, 2010, Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma, Crit Care, 14, R208, 10.1186/cc9331 · DOI
  22. Ditschkowski, 1999, HLA-DR expression and soluble HLA-DR levels in septic patients after trauma, Ann Surg, 229, 246, 10.1097/00000658-199902000-00013 · DOI
  23. da Silva, 2013, HLA-A ∗ 31 as a marker of genetic susceptibility to sepsis, Rev Bras Ter Intensiva, 25, 284, 10.5935/0103-507X.20130049 · DOI
  24. Eguia, 2019, Risk factors for infection and evaluation of Sepsis-3 in patients with trauma, XXXX, 218, 851
  25. Shepherd, 2017, Contemporary patterns of multiple organ dysfunction in trauma, Shock, 47, 429, 10.1097/SHK.0000000000000779 · DOI
  26. Menéndez, 2019, Simultaneous depression of immunological synapse and endothelial injury is associated with organ dysfunction in community-acquired pneumonia, J Clin Med, 8, 1404, 10.3390/jcm8091404 · DOI
  27. Haffner, 1996, Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells, Proc Natl Acad Sci, 93, 3037, 10.1073/pnas.93.7.3037 · DOI
  28. Llewelyn, 2004, HLA class II polymorphisms determine responses to bacterial superantigens, J Immunol, 172, 1719, 10.4049/jimmunol.172.3.1719 · DOI
  29. Wang, 2020, iCn3D, a web-based 3D viewer for sharing 1D/2D/3D representations of biomolecular structures, Bioinformatics, 36, 131, 10.1093/bioinformatics/btz502 · DOI
  30. Badrinath, 2014, A micropolymorphism altering the residue triad 97/114/156 determines the relative levels of tapasin independence and distinct peptide profiles for HLA-A ∗ 24 allotypes, J Immunol Res, 2014, 298145, 10.1155/2014/298145 · DOI
  31. Wafaisade, 2011, Epidemiology and risk factors of sepsis after multiple trauma: an analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery, Crit Care Med, 39, 621, 10.1097/CCM.0b013e318206d3df · DOI
  32. Mersha, 2015, Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities, Hum Genomics, 9, 1, 10.1186/s40246-014-0023-x · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Horn, D. L., Mindrinos, M., Anderson, K., Krishnakumar, S., Wang, C., Li, M., Hollenbach, J., & O’Keefe, G. E.
Affiliations
  • University of Washington, Seattle, Washington
  • Stanford University, Stanford, California
  • University of California, San Francisco, California.
  • Immucor, Peachtree Corners, Georgia
Venue
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-05-18
Volume
275
Issue
1
Pages
203-207
ISSN
  • 0003-4932
  • 1528-1140
DOI
10.1097/sla.0000000000003932
PMC
PMC10060028
Cited by
8
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review