The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Long-Term Survival After Pancreatoduodenectomy for Pancreatic Adenocarcinoma: Is Cure Possible?
Abstract
OBJECTIVE: To determine long-term survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma and to identify clinical factors associated with long-term survival. SUMMARY BACKGROUND DATA: The prognosis for long-term survival even after potentially curative resection for pancreatic adenocarcinoma is thought to be poor. Clinical factors determining short-term survival after pancreatic resection are well studied, but prognostic factors predicting long-term survival with a potential for cure are poorly understood. METHODS: A case-control study was conducted of 357 patients who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 1981 and 2001. Histologic specimens were reanalyzed to confirm diagnosis. Follow-up was at least 5 years or until death. RESULTS: There was an improved survival throughout the observation period (P = 0.004). We found 62 actual 5-year survivors of whom 21 patients survived greater than 10 years, for a 5- and 10-year survival rate of 18% and 13%, respectively. Cohort analysis comparing patients with short-term (<5 years, n = 295) and long-term (> or =5 years, n = 62) survival showed that more advanced disease (greatest tumor diameter, lymph node metastasis) and decreased serum albumin concentration were unfavorable for long-term survival (all P < 0.05). In contrast, the extent of resection and more aggressive histologic features did not correlate with long-term survival (all P > 0.05). En-bloc resection (P = 0.005) but not resection margin status (P > 0.05) was associated with long-term survival. Adjuvant chemoradiation therapy did not significantly influence long-term survival. Multivariate analysis identified lymph node status (OR 0.36, 95% CI 0.14-0.89, P = 0.03) as a prognostic factor for long-term survival. Five-year survival was no guarantee of cure because 16% of this subset died of pancreatic cancer up to 7.8 years after operation. CONCLUSION: Pancreatoduodenectomy for adenocarcinoma in the head of pancreas can provide long-term survival in a subset of patients, particularly in the absence of lymph node metastasis. One of 8 patients can achieve 10-year survival with a potential for cure.
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Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer
Neoptolemos, J. P., Stocken, D. D., Friess, H., Bassi, C., Dunn, J. A., Hickey, H., Beger, H., Fernandez-Cruz, L., Dervenis, C., Lacaine, F., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032295 · Cited by 2,716
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1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience
Winter, J. M., Cameron, J. L., Campbell, K. A., Arnold, M. A., Chang, D. C., Coleman, J., Hodgin, M. B., Sauter, P. K., Hruban, R. H., Riall, T. S., et al. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.08.018 · Cited by 1,489
Wagner, M., Redaelli, C., Lietz, M., Seiler, C. A., Friess, H., & Büchler, M. W. (2004) · British Journal of Surgery · doi:10.1002/bjs.4484 · Cited by 844
Conlon, K. C., Klimstra, D. S., & Brennan, M. F. (1996) · Annals of Surgery · doi:10.1097/00000658-199603000-00007 · Cited by 709
Long-Term Survival After Resection for Ductal Adenocarcinoma of the Pancreas Is It Really Improving?
Nitecki, S. S., Sarr, M. G., Colby, T. V., & van Heerden, J. A. (1995) · Annals of Surgery · doi:10.1097/00000658-199501000-00007 · Cited by 586
Self-citationLim, J. E., Chien, M. W., & Earle, C. C. (2003) · Annals of Surgery · doi:10.1097/00000658-200301000-00011 · Cited by 586
National Failure to Operate on Early Stage Pancreatic Cancer
Bilimoria, K. Y., Bentrem, D. J., Ko, C. Y., Stewart, A. K., Winchester, D. P., & Talamonti, M. S. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e3180691579 · Cited by 554
Richter, A., Niedergethmann, M., Sturm, J. W., Lorenz, D., Post, S., & Trede, M. (2003) · World Journal of Surgery · doi:10.1007/s00268-002-6659-z · Cited by 401
Cited by
Preoperative Biliary Drainage for Cancer of the Head of the Pancreas
van der Gaag, N. A., Rauws, E. A. J., van Eijck, C. H. J., Bruno, M. J., van der Harst, E., Kubben, F. J. G. M., Gerritsen, J. J. G. M., Greve, J. W., Gerhards, M. F., de Hingh, I. H. J. T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0903230 · Cited by 1,049
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784
“Long-term survival can be achieved by resecting small non-metastatic PCs, 59 60 particularly if margins are negative for invasive PC (R0 resection).”
BackgroundGroot, V. P., Rezaee, N., Wu, W., Cameron, J. L., Fishman, E. K., Hruban, R. H., Weiss, M. J., Zheng, L., Wolfgang, C. L., & He, J. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002234 · Cited by 757
Margin Clearance and Outcome in Resected Pancreatic Cancer
Chang, D. K., Johns, A. L., Merrett, N. D., Gill, A. J., Colvin, E. K., Scarlett, C. J., Nguyen, N. Q., Leong, R. W. L., Cosman, P. H., Kelly, M. I., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.5104 · Cited by 309
Recurrence After Liver Transplantation for Hepatocellular Carcinoma: A New MORAL to the Story
Halazun, K. J., Najjar, M., Abdelmessih, R. M., Samstein, B., Griesemer, A. D., Guarrera, J. V., Kato, T., Verna, E. C., Emond, J. C., & Brown, R. S. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000001966 · Cited by 281
Metadata
- Authors
- Schnelldorfer, T., Ware, A. L., Sarr, M. G., Smyrk, T. C., Zhang, L., Qin, R., Gullerud, R. E., Donohue, J. H., Nagorney, D. M., & Farnell, M. B.
- Venue
- Annals of Surgery
- Published
- 2008-03
- Volume
- 247
- Issue
- 3
- Pages
- 456-462
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2113662908
- Cited by
- 458
- References
- 18
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schnelldorfer, T., Ware, A. L., Sarr, M. G., Smyrk, T. C., Zhang, L., Qin, R., Gullerud, R. E., Donohue, J. H., Nagorney, D. M., & Farnell, M. B. (2008). Long-Term Survival After Pancreatoduodenectomy for Pancreatic Adenocarcinoma: Is Cure Possible? Annals of Surgery. https://doi.org/10.1097/sla.0b013e3181613142
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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