The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Out-of-hospital Hypertonic Resuscitation After Traumatic Hypovolemic Shock: A Randomized, Placebo Controlled Trial
Open accessAbstract
OBJECTIVE: To determine whether out-of-hospital administration of hypertonic fluids would improve survival after severe injury with hemorrhagic shock. BACKGROUND: Hypertonic fluids have potential benefit in the resuscitation of severely injured patients because of rapid restoration of tissue perfusion, with a smaller volume, and modulation of the inflammatory response, to reduce subsequent organ injury. METHODS: Multicenter, randomized, blinded clinical trial, May 2006 to August 2008, 114 emergency medical services agencies in North America within the Resuscitation Outcomes Consortium. INCLUSION CRITERIA: injured patients, age ≥ 15 years with hypovolemic shock (systolic blood pressure ≤ 70 mm Hg or systolic blood pressure 71-90 mm Hg with heart rate ≥ 108 beats per minute). Initial resuscitation fluid, 250 mL of either 7.5% saline per 6% dextran 70 (hypertonic saline/dextran, HSD), 7.5% saline (hypertonic saline, HS), or 0.9% saline (normal saline, NS) administered by out-of-hospital providers. Primary outcome was 28-day survival. On the recommendation of the data and safety monitoring board, the study was stopped early (23% of proposed sample size) for futility and potential safety concern. RESULTS: : A total of 853 treated patients were enrolled, among whom 62% were with blunt trauma, 38% with penetrating. There was no difference in 28-day survival-HSD: 74.5% (0.1; 95% confidence interval [CI], -7.5 to 7.8); HS: 73.0% (-1.4; 95% CI, -8.7-6.0); and NS: 74.4%, P = 0.91. There was a higher mortality for the postrandomization subgroup of patients who did not receive blood transfusions in the first 24 hours, who received hypertonic fluids compared to NS [28-day mortality-HSD: 10% (5.2; 95% CI, 0.4-10.1); HS: 12.2% (7.4; 95% CI, 2.5-12.2); and NS: 4.8%, P < 0.01]. CONCLUSION: Among injured patients with hypovolemic shock, initial resuscitation fluid treatment with either HS or HSD compared with NS, did not result in superior 28-day survival. However, interpretation of these findings is limited by the early stopping of the trial. CLINICAL TRIAL REGISTRATION: Clinical Trials.gov, NCT00316017.
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Preventable or Potentially Preventable Mortality at a Mature Trauma Center
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Colloids versus crystalloids for fluid resuscitation in critically ill patients
Perel, P., Roberts, I., & Ker, K. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000567.pub6 · Cited by 1,115
Gonzalez, E., Moore, E. E., Moore, H. B., Chapman, M. P., Chin, T. L., Ghasabyan, A., Wohlauer, M. V., Barnett, C. C., Bensard, D. D., Biffl, W. L., et al. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001608 · Cited by 641
Colloids versus crystalloids for fluid resuscitation in critically ill people
Lewis, S. R., Pritchard, M. W., Evans, D. J., Butler, A. R., Alderson, P., Smith, A. F., & Roberts, I. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000567.pub7 · Cited by 315
Self-citationMartin, G. S., & Bassett, P. (2019) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.11.031 · Cited by 141
Tarabichi, Y., Cheng, A., Bar-Shain, D., McCrate, B. M., Reese, L. H., Emerman, C., Siff, J., Wang, C., Kaelber, D. C., Watts, B., et al. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005267 · Cited by 76
Metadata
- Authors
- Bulger, E. M., May, S., Kerby, J. D., Emerson, S., Stiell, I. G., Schreiber, M. A., Brasel, K. J., Tisherman, S. A., Coimbra, R., Rizoli, S., Minei, J. P., Hata, J. S., Sopko, G., Evans, D. C., & Hoyt, D. B.
- Venue
- Annals of Surgery
- Published
- 2011-03
- Volume
- 253
- Issue
- 3
- Pages
- 431-441
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2164315467
- Cited by
- 284
- References
- 32
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Bulger, E. M., May, S., Kerby, J. D., Emerson, S., Stiell, I. G., Schreiber, M. A., Brasel, K. J., Tisherman, S. A., Coimbra, R., Rizoli, S., Minei, J. P., Hata, J. S., Sopko, G., Evans, D. C., & Hoyt, D. B. (2011). Out-of-hospital Hypertonic Resuscitation After Traumatic Hypovolemic Shock: A Randomized, Placebo Controlled Trial. Annals of Surgery. https://doi.org/10.1097/sla.0b013e3181fcdb22
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
