Alterations of Global Gastrointestinal Motility After Sleeve Gastrectomy: A Prospective Study
Abstract
OBJECTIVES: To evaluate the role of sleeve gastrectomy (SG) in gastrointestinal motility. BACKGROUND: SG is a widely used bariatric operation leading to weight loss and early improvement of patient's metabolic profile. Current data indicate faster postoperative gastric emptying, but detailed studies on alterations in small bowel motility are missing. DESIGN: We evaluated 21 morbidly obese patients who underwent laparoscopic SG before and 4 months after the procedure. After consumption of a semisolid radiolabeled meal, their gastric and intestinal transit times were studied with a gamma camera. Particularly the times of 10% gastric emptying, 50% gastric emptying, maximal intestinal filling, 10% terminal ileum filling, duodenal to terminal ileum transit, cecal filling initiation, and ileocecal valve transit (T ICVt) were studied pre- and postoperatively. RESULTS: Ten percent gastric emptying and 50% gastric emptying were decreased postoperatively as well as maximal intestinal filling, indicating faster gastric emptying and intestinal filling. Duodenal to terminal ileum transit and 10% terminal ileum filling also decreased as small bowel transit time accelerated and the meal reached the terminal ileum more rapidly. Contrary opening of the ileocecal valve and food transit through it were delayed, with postoperative increase in cecal filling initiation and T ICVt, respectively. CONCLUSIONS: SG accelerates gastric emptying and small bowel transit of semisolids. In addition, it delays the initiation of cecal filling and T ICVt. This early and prolonged contact of food with the distal small bowel mucosa may explain the metabolic effects of SG occurring before substantial weight loss.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sleeve gastrectomy aids expedition of nutrients out of the stomach and through the proximal small bowel to quickly reach the ileum.
“Nuclear imaging studies tracking the transit of a mixed meal have shown that sleeve gastrectomy aids expedition of nutrients out of the stomach and through the proximal small bowel to quickly reach the ileum [133].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [133]
Cites
Bariatric Surgery: A Systematic Review and Meta-analysis
Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) · JAMA · doi:10.1001/jama.292.14.1724 · Cited by 6,800 · see citing works
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works
Overweight, Obesity, and Health Risk
National Task Force on the Prevention and Treatment of Obesity (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.7.898 · Cited by 963 · see citing works
Karamanakos, S. N., Vagenas, K., Kalfarentzos, F. E., & Alexandrides, T. K. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318156f012 · Cited by 814 · see citing works
McTigue, K. M., Harris, R., Hemphill, B., Lux, L. J., Sutton, S. F., Bunton, A. J., & Lohr, K. N. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00013 · Cited by 601 · see citing works
Systematic review of sleeve gastrectomy as staging and primary bariatric procedure
Brethauer, S. A., Hammel, J., & Schauer, P. R. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.05.011 · Cited by 535 · see citing works
Laparoscopic Sleeve Gastrectomy: A Multi-purpose Bariatric Operation
Baltasar, A., Serra, C., Pérez, N., Bou, R., Bengochea, M., & Ferri, L. (2005) · Obesity Surgery · doi:10.1381/0960892055002248 · Cited by 498 · see citing works
Abell, T. L., Camilleri, M., Donohoe, K. J., Hasler, W. L., Lin, H. C., Maurer, A. H., McCallum, R. W., Nowak, T. V., Nusynowitz, M. L., Parkman, H. P., et al. (2008) · Journal of Nuclear Medicine Technology · doi:10.2967/jnmt.107.048116 · Cited by 441 · see citing works
Medicinal strategies in the treatment of obesity
Bray, G. A., & Tartaglia, L. A. (2000) · Nature · doi:10.1038/35007544 · Cited by 432 · see citing works
Laparoscopic Sleeve Gastrectomy—Volume and Pressure Assessment
Yehoshua, R. T., Eidelman, L., Stein, M., Fichman, S., Mazor, A., Chen, J., Bernstine, H., Singer, P., Dickman, R., Beglaibter, N., et al. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9576-x · Cited by 415 · see citing works
Sleeve Gastrectomy — A Restrictive Procedure?
Melissas, J., Koukouraki, S., Askoxylakis, J., Stathaki, M., Daskalakis, M., Perisinakis, K., & Karkavitsas, N. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9006-5 · Cited by 402 · see citing works
Self-citationThird International Summit: current status of sleeve gastrectomy
Deitel, M., Gagner, M., Erickson, A. L., & Crosby, R. D. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.07.017 · Cited by 391 · see citing works
Overweight and Obesity Worldwide now Estimated to Involve 1.7 Billion People
Deitel, M. (2003) · Obesity Surgery · doi:10.1381/096089203765887598 · Cited by 380 · see citing works
Influence of ghrelin on interdigestive gastrointestinal motility in humans
Tack, J., Depoortere, I., Bisschops, R., Delporte, C., Coulie, B., Meulemans, A., Janssens, J., & Peeters, T. (2005) · Gut · doi:10.1136/gut.2004.060426 · Cited by 359 · see citing works
Gastrointestinal hormones regulating appetite
Chaudhri, O. B., Small, C. J., & Bloom, S. R. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1856 · Cited by 347 · see citing works
Human gastric pacesetter potential
Hinder, R. A., & Kelly, K. A. (1977) · The American Journal of Surgery · doi:10.1016/0002-9610(77)90187-8 · Cited by 291 · see citing works
Longitudinal Gastrectomy as a Treatment for the High-Risk Super-Obese Patient
Almogy, G., Crookes, P. F., & Anthone, G. J. (2004) · Obesity Surgery · doi:10.1381/096089204323013479 · Cited by 287 · see citing works
Sleeve Gastrectomy—A “Food Limiting” Operation
Melissas, J., Daskalakis, M., Koukouraki, S., Askoxylakis, I., Metaxari, M., Dimitriadis, E., Stathaki, M., & Papadakis, J. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9634-4 · Cited by 280 · see citing works
Self-citationVidal, J., Ibarzábal, A., Romero, F., Delgado, S., Momblan, D. N. D. M., Flores, L., & Lacy, A. M. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9547-2 · Cited by 272 · see citing works
Deitel, M., Gawdat, K., & Melissas, J. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9116-0 · Cited by 267 · see citing works
Self-citationNeurohumoral control of gastrointestinal motility
Hansen, M. (2003) · Physiological Research · doi:10.33549/physiolres.930255 · Cited by 246 · see citing works
Braghetto, I., Davanzo, C., Korn, O., Csendes, A., Valladares, H., Herrera, E., González, P., & Papapietro, K. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9954-z · Cited by 235 · see citing works
Mechanisms of early improvement / resolution of type 2 diabetes after bariatric surgery
Mingrone, G., & Castagneto‐Gissey, L. (2009) · Diabetes & Metabolism · doi:10.1016/s1262-3636(09)73459-7 · Cited by 171 · see citing works
Alterations of Gastrointestinal Motility in Obesity
Xing, J., & Chen, J. D. Z. (2004) · Obesity Research · doi:10.1038/oby.2004.213 · Cited by 160 · see citing works
Shah, S. S., Shah, P. S., Todkar, J. S., Gagner, M., Sonar, S. J., & Solav, S. V. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.11.019 · Cited by 153 · see citing works
Read, N. W., Al-Janabi, M., Holgate, A. M., et al. (1986) · Gut · doi:10.1136/gut.27.3.300 · Cited by 140 · see citing works
Bernstine, H., Tzioni-Yehoshua, R., Groshar, D., Beglaibter, N., Shikora, S., Rosenthal, R., & Rubin, M. (2009) · Obesity Surgery · doi:10.1007/s11695-008-9791-5 · Cited by 136 · see citing works
Early Postoperative Insulin-Resistance Changes After Sleeve Gastrectomy
Rizzello, M., Abbatini, F., Casella, G., Alessandri, G., Fantini, A., Leonetti, F., & Basso, N. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0017-2 · Cited by 130 · see citing works
Alterations in Gut Hormones After Laparoscopic Sleeve Gastrectomy
Dimitriadis, E., Daskalakis, M., Kampa, M., Peppe, A., Papadakis, J. A., & Melissas, J. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31826e1846 · Cited by 122 · see citing works
Self-citationWisén, O., & Johansson, C. (1992) · Metabolism · doi:10.1016/0026-0495(92)90073-j · Cited by 119 · see citing works
Greenstein, R. J., & Deitel, M. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9218-8 · Cited by 108 · see citing works
Motility of the ileocolonic junction.
Phillips, S. F., Quigley, E. M. M., Kumar, D., et al. (1988) · Gut · doi:10.1136/gut.29.3.390 · Cited by 105 · see citing works
Baumann, T., Kuesters, S., Grueneberger, J., Marjanovic, G., Zimmermann, L., Schaefer, A., Hopt, U., Langer, M., & Karcz, W. (2011) · Obesity Surgery · doi:10.1007/s11695-010-0317-6 · Cited by 101 · see citing works
Short-term Effects of Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Severely Obese Subjects
Vidal, J., Ibarzábal, A., Nicolau, J. C., Vidov, M., Delgado, S., Martinez, G., Balust, J., Morı́nigo, R., & Lacy, A. M. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9180-5 · Cited by 101 · see citing works
Manometric Characteristics of the Human Ileocecal Junctional Zone
Cohen, S., Harris, L. D., & Levitan, R. (1968) · Gastroenterology · doi:10.1016/s0016-5085(68)80040-x · Cited by 91 · see citing works
Santoro, S., Milléo, F. Q., Malzoni, C. E., Klajner, S., Borges, P. C. M., Santo, M. A., Campos, F. G., & Artoni, R. F. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9371-0 · Cited by 82 · see citing works
Scopinaro, N., Papadia, F. S., Marinari, G. M., Camerini, G. B., & Adami, G. F. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9045-y · Cited by 80 · see citing works
Evaluation of small-bowel transit for solid and liquid test meal in healthy men and women
Bennink, R. J., Peeters, M., den Maegdenbergh, V. V., Geypens, B. J., Rutgeerts, P. J., Roo, M. D., & Mortelmans, L. A. (1999) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050495 · Cited by 70 · see citing works
Islet Amyloid Polypeptide in the Gut and Pancreas
Mulder, H., Ekelund, M., Ekblad, E., & Sundler, F. (1997) · Peptides · doi:10.1016/s0196-9781(97)00008-9 · Cited by 54 · see citing works
Radionuclide Evaluation of the Lower Gastrointestinal Tract
Mariani, G., Pauwels, E. K. J., AlSharif, A. A., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.040113 · Cited by 54 · see citing works
Interdigestive Gastroduodenal Motility and Cycling of Putative Regulatory Hormones in Severe Obesity
Pieramico, O., Malfertheiner, P., Nelson, D. K., Glasbrenner, B., & DITSCHUNEIT, H. H. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209000117 · Cited by 43 · see citing works
Altered intestinal motility in leptin-deficient obese mice1
Kiely, J. M., Noh, J. H., Graewin, S. J., et al. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2004.10.005 · Cited by 40 · see citing works
Amylin is associated with delayed gastric emptying in critically ill children
Mayer, A.-P. T., Durward, A., Turner, C., Skellett, S., Dalton, N. R., Tibby, S. M., & Murdoch, I. A. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1224-7 · Cited by 37 · see citing works
The surgical significance of the ileo-caecal junction.
Jc, G. (1968) · PubMed · Cited by 36 · see citing works
Standardization and quantification of radionuclide solid gastric-emptying studies.
Ziessman, H. A., Fahey, F. H., Atkins, F., et al. (2004) · PubMed · Cited by 34 · see citing works
Pressure responses of canine ileocolonic junctional zone to intestinal distention
Ml, K., Gordon, E. S., & Deweese, J. (1966) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1966.211.3.614 · Cited by 32 · see citing works
Anastomotic leaks after bariatric surgery: it is the host response that matters
Al-Sabah, S. K., Ladouceur, M., & Christou, N. V. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2007.12.010 · Cited by 27 · see citing works
Fundic Balloon Distension Stimulates Antral and Duodenal Motility in Man
Rao, S. S. C., Vemuri, S., Harris, B., & Schulze, K. S. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1015077721427 · Cited by 26 · see citing works
The surgical significance of the ileo-caecal junction
Corkery, J. J. (1969) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(69)90231-0 · Cited by 18 · see citing works
Assessment of gastric emptying and myoelectric activity in the morbidly obese patient
McCallum, R. W., Jones, T. F., Lin, Z., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)81439-4 · Cited by 10 · see citing works
Assessment of gastric emptying and myoelectric activity in the morbidly obese patient
McCallum, R. W., JONES, T., LIN, Z., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)81439-6 · Cited by 6 · see citing works
Ca2+ activated Cl− but not K+ channels in NCM460 cells
Jones, H. M., Moyer, M. P., Lance, P., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)82619-4 · Cited by 4 · see citing works
Melcher, R., Luehrs, H., Menzel, T. P., et al. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)81441-2 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects
Biobaku, F., Ghanim, H., Monte, S. V., Caruana, J. A., & Dandona, P. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa049 · Cited by 68 · see citing works
Do Gut Hormones Contribute to Weight Loss and Glycaemic Outcomes after Bariatric Surgery?
Papamargaritis, D., & le Roux, C. W. (2021) · Nutrients · doi:10.3390/nu13030762 · Cited by 68 · see citing works
- Authors
- Melissas, J., Leventi, A., Klinaki, I., Perisinakis, K., Koukouraki, S., de Bree, E., & Karkavitsas, N.
- Affiliations
- University of Crete (GR)
- University Hospital of Heraklion (GR)
- Corresponding author
- Melissas, John
- Leventi, Aikaterini
- Venue
- Annals of Surgery
- Published
- 2013-12
- Volume
- 258
- Issue
- 6
- Pages
- 976-982
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2053712359
- Cited by
- 155
- References
- 54
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 15 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 22 · 2014: 6 · 2013: 7
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- sleeve gastrectomy, gastrointestinal motility, gastric emptying, small intestinal transit, morbid obesity, bariatric surgery
- MeSH terms
- Adult, Female, Gastrectomy, Gastrointestinal Motility, Humans, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
