The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Long-term prescription opioid utilization, substance use disorders, and opioid overdoses after adolescent trauma
Open accessAbstract
BACKGROUND: Injured adolescents have a 56% increased risk of developing a substance use disorder (SUD) within 3 years of their injury. The transition from medical prescription opioid use to nonmedical use in adolescent trauma patients has not been longitudinally studied long-term. The aim of this study is to describe 5-year patterns of opioid use in a cohort of injured adolescents as well as the proportion of patients experiencing overdose and SUD diagnoses. METHODS: Our retrospective cohort study consisted of 736 patients aged 12 years to 18 years who were admitted for trauma from 2011 to 2013. We examined up to 5 years of regional health information exchange data containing information on prescription fills as well as diagnoses from inpatient, outpatient, and emergency department encounters. RESULTS: At 1 year, over 20% of adolescents filled more than two opioid prescriptions after being discharged for their injury; and at 4 years, over 13% had received more than eight opioid fills. Over the 5-year period, 11% received an opioid antagonist injection, 14% received an SUD diagnosis, and 8% had an overdose diagnosis. Relatively few patients had diagnoses for other mental health conditions including depression (5.5%), posttraumatic stress disorder (2.1%), and chronic pain (3.6%). CONCLUSION: Opioid usage remains high for multiple years in a subset of the adolescent trauma population. Mental health diagnosis rates were substantially lower in injured adolescents than what has been reported in adults. However, overdose and SUD diagnoses occur in over 1 in 10 adolescents within 5 years of their injury. LEVEL OF EVIDENCE: Prognostic and epidemiological study, level IV.
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“Of high school students reporting opioid misuse, 80% reported they were initially prescribed to them by a physician, and persistent opioid prescriptions and substance use disorders are high 4 years after traumatic injury [51, 52].”
From Adolescent Suicide—Understanding Unique Risks and Opportunities for Trauma Centers to Recognize, Intervene, and Prevent a Leading Cause of Death (2022) · cites this paper as [52]
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“Of high school students reporting opioid misuse, 80% reported they were initially prescribed to them by a physician, and persistent opioid prescriptions and substance use disorders are high 4 years after traumatic injury [51, 52].”
From Adolescent Suicide—Understanding Unique Risks and Opportunities for Trauma Centers to Recognize, Intervene, and Prevent a Leading Cause of Death (2022) · cites this paper as [52]
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Cites
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Initiation into prescription opioid misuse amongst young injection drug users
Lankenau, S. E., Teti, M., Silva, K., Bloom, J. J., Harocopos, A., & Treese, M. (2012) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2011.05.014 · Cited by 440 · cited 1×
“Instead, the use of prescription opioids obtained from friends and family members, in addition to the use of illicit drugs, may present a greater risk for this population.(30) Identification of risk factors for using illicit drugs, SUDs, and future overdoses will provide greater insight into providers' opportunities f…”
BackgroundThe Indiana Network For Patient Care: A Working Local Health Information Infrastructure
McDonald, C. J., Overhage, J. M., Barnes, M., Schadow, G., Blevins, L., Dexter, P. R., Mamlin, B., & the INPC Management Committee (2005) · Health Affairs · doi:10.1377/hlthaff.24.5.1214 · Cited by 330
Psychoactive Substance Use Disorders Among Seriously Injured Trauma Center Patients
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Medical and Nonmedical Use of Prescription Drugs among Secondary School Students
McCabe, S. E., Boyd, C. J., & Young, A. M. (2006) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2006.07.016 · Cited by 189
Zatzick, D. F., Jurkovich, G. J., Fan, M.-Y., Grossman, D., Russo, J., Katon, W., & Rivara, F. P. (2008) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.162.7.642 · Cited by 163
Medical and Nonmedical Use of Prescription Opioids Among High School Seniors in the United States
McCabe, S. E. (2012) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2012.85 · Cited by 158
Drug Overdose Deaths Among Adolescents Aged 15-19 in the United States: 1999-2015.
Curtin, S. C., Tejada‐Vera, B., & Warmer, M. (2017) · PubMed · Cited by 136
Manchikanti, L., Abdi, S., Atluri, S. L., Balog, C. C., Benyamin, R. M., Boswell, M. V., Brown, K. R., Bruel, B. M., Bryce, D. A., Burks, P. A., et al. (2012) · PubMed · Cited by 129
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Hink, A. B., Killings, X., Bhatt, A., Ridings, L. E., & Andrews, A. L. (2022) · Current Trauma Reports · doi:10.1007/s40719-022-00223-7 · Cited by 67
Metadata
- Authors
- Bell, T. M., Raymond, J., Vetor, A., Mongalo, A., Adams, Z., Rouse, T., & Carroll, A.
- Affiliations
- Indiana University Health (US)
- Venue
- Journal of Trauma and Acute Care Surgery
- Published
- 2019-03-19
- Volume
- 87
- Issue
- 4
- Pages
- 836-840
- ISSN
- 2163-0755 (ISSN-L)
- 2163-0763
- PMC
- PMC6745292
- OpenAlex
- W2931455384
- Cited by
- 28
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Trauma: Injury, Infection, and Critical Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health (KL2TR002530, TL1TR001107, UL1TR002529)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD097452)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
- Keywords
- prescription opioid use, adolescent trauma, substance use disorders, opioid overdose, nonmedical opioid use, mental health diagnoses, post-traumatic stress disorder, chronic pain, depression, pediatric trauma
- MeSH terms
- Long Term Adverse Effects, Adolescent, Analgesics, Opioid, Female, Humans, Male, Opioid-Related Disorders, Prognosis, Retrospective Studies, United States, Wounds and Injuries, Cohort Studies, Inappropriate Prescribing, Chronic Pain, Drug Overdose
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