The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
High Risk of Graft Failure in Patients With Anti-HLA Antibodies Undergoing Haploidentical Stem-Cell Transplantation
Open accessAbstract
BACKGROUND.: Although donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) have been implicated in graft rejection in solid organ transplantation, their role in hematopoietic stem-cell transplantation remains unclear. METHODS.: To address the hypothesis that the presence of DSA contributes to the development graft failure, we tested 24 consecutive patients for the presence of anti-HLA antibodies determined by a sensitive and specific solid-phase/single-antigen assay. The study included a total of 28 haploidentical transplants, each with 2 to 5 HLA allele mismatches, at a single institution, from September 2005 to August 2008. RESULTS.: DSA were detected in five patients (21%). Three of four (75%) patients with DSA before the first transplant failed to engraft, compared with 1 of 20 (5%) without DSA (P=0.008). All four patients who experienced primary graft failure had second haploidentical transplants. One patient developed a second graft failure with persistent high DSA levels, whereas three engrafted, two of them in the absence of DSA. No other known factors that could negatively influence engraftment were associated with the development of graft failure in these patients. CONCLUSIONS.: These results suggest that donor-specific anti-HLA antibodies are associated with a high rate of graft rejection in patients undergoing haploidentical stem-cell transplantation. Anti-HLA sensitization should be evaluated routinely in hematopoietic stem-cell transplantation with HLA mismatched donors.
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Cites
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Self-citationMarrow Transplantation from Related Donors Other Than HLA-Identical Siblings
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Cited by
Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy?
Leonard, A., Tisdale, J., & Abraham, A. (2020) · British Journal of Haematology · doi:10.1111/bjh.16437 · Cited by 45
Metadata
- Authors
- Ciurea, S. O., de Lima, M., Cano, P., Korbling, M., Giralt, S., Shpall, E. J., Wang, X., Thall, P. F., Champlin, R. E., & Fernandez-Vina, M.
- Venue
- Transplantation
- Published
- 2009-10-27
- Volume
- 88
- Issue
- 8
- Pages
- 1019-1024
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2075510710
- Cited by
- 287
- References
- 25
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Ciurea, S. O., de Lima, M., Cano, P., Korbling, M., Giralt, S., Shpall, E. J., Wang, X., Thall, P. F., Champlin, R. E., & Fernandez-Vina, M. (2009). High Risk of Graft Failure in Patients With Anti-HLA Antibodies Undergoing Haploidentical Stem-Cell Transplantation. Transplantation. https://doi.org/10.1097/tp.0b013e3181b9d710
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