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Cited by 10Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchTrauma, Hemostasis, Coagulopathy, Resuscitation

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Sugar as a therapeutic target for the cognitive restoration following traumatic brain injury

Kumar, Amit·2019·Current Opinion in Neurology
DOI 10.1097/wco.0000000000000752
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Abstract

Purpose of review: This review aims to discuss examples of changes in glucose (sugar) metabolism after traumatic brain injury (TBI). It will attempt to provide an understanding of what changes in glucose metabolism mean for the injured brain. It will further identify potential therapeutic target(s) emanating from our growing understanding of glucose pathways and their roles in TBI. Recent findings: Although a significant fraction of glucose is utilized for the energy production in the brain, a small fraction is utilized in other, often ignored pathways. Recent studies have unraveled unexpected biological effects of glucose through these pathways, including redox regulation, genetic and epigenetic regulation, glycation of proteins, nucleotide synthesis and amino acid synthesis. Summary: A number of regulatory players in minor glucose metabolic pathways, such as folate and chondroitin sulfate proteoglycans, have recently been identified as potential targets to restore cognitive functions. Targeting of these players should be combined with the supplementation of alternative energy substrates to achieve the maximal cognitive restoration after TBI. This multimodal therapeutic strategy deserves testing in various models of TBI. Video abstract: Supplemental digital video content 1: Video that demonstrates an effective therapeutic strategy for the cognitive restoration after TBI. http://links.lww.com/CONR/A46.

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Metadata

Authors
Kumar, A.
Affiliations
Weill Cornell Medicine (US)
Corresponding author
Kumar, Amit
ORCID
Kumar, Amit
Venue
Current Opinion in Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-12
Volume
32
Issue
6
Pages
815-821
ISSN
  • 1350-7540 (ISSN-L)
  • 1473-6551
DOI
10.1097/wco.0000000000000752
OpenAlex
W2980911281
Cited by
10
References
5
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1
FWCI
0.10
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
traumatic brain injury, glucose metabolism, cognitive restoration, therapeutic target, redox regulation, epigenetic regulation, protein glycation, nucleotide synthesis, amino acid synthesis, folic acid, chondroitin sulfate proteoglycans, brain energy metabolism
MeSH terms
Brain Injuries, Traumatic, Adaptation, Physiological, Glucose, Humans, Metabolic Networks and Pathways

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