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Cited by 219Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Reichelt, Amy C., Hare, Dominic J., Bussey, Timothy J., Saksida, Lisa M.·2019·Trends in Neurosciences
DOI 10.1016/j.tins.2019.04.003
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Abstract

The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.

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  • Newly formed memory traces can interfere with the fidelity and recall of previously learned information, as evident by impaired reconsolidation and recall of remote memories following perineuronal net ablation.

    “newly formed memory traces can interfere with the fidelity and recall of previously learned information [20], as evident by impaired reconsolidation and recall of remote memories following PNN ablation [25, 26].”

    From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [20]

  • Enhanced plasticity and learning can impair storage and recall of remote memories due to interference from new memory traces, and so enhancement of these factors following PNN loss would still be consistent with impaired reconsolidation and recall of remote, long-term memories.

    “On the other hand, enhanced plasticity and learning can impair the storage and recall of remote memories due to interference from new memory traces [20], and so the enhancement of these factors following PNN loss would still be consistent with the consequently impaired reconsolidation and recall of remote, long-term memories reported by others [25, 26].”

    From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [20]

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Authors
Reichelt, A. C., Hare, D. J., Bussey, T. J., & Saksida, L. M.
Affiliations
  • Western University (CA)
  • The University of Melbourne (AU)
Corresponding author
Reichelt, Amy C.
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2019-07
Volume
42
Issue
7
Pages
458-470
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2019.04.003
OpenAlex
W2948487620
Semantic Scholar
1f56e157b8de6315ec7412f54fba23df9b9e6d9a
Cited by
219
References
29
Citations by year
2026: 28 · 2025: 41 · 2024: 42 · 2023: 28 · 2022: 30 · 2021: 28 · 2020: 18 · 2019: 4
FWCI
2.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Scholarship@Western (Western University) (submittedVersion)
  • UTS ePRESS (University of Technology Sydney) (submittedVersion)
Funders
  • Canada First Research Excellent Fund
  • Australian Research Council (DP180101974)
  • National Health and Medical Research Council (1122981)
  • Canadian Institute for Advanced Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
perineuronal nets, neuroplasticity, synaptic plasticity, parvalbumin interneurons, critical period, neuroprotection, cognitive decline, neurodegeneration, neurotoxins
MeSH terms
Animals, Brain, Cognition, Extracellular Matrix, Humans, Nerve Net, Neuronal Plasticity

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