Combined neuromodulatory approaches in the central nervous system for treatment of spinal cord injury

Harnessing neuroplasticity for clinical applications

Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259

Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study

Harkema, S., Gerasimenko, Y., Hodes, J., Burdick, J., Angeli, C., Chen, Y., Ferreira, C., Willhite, A., Rejc, E., Grossman, R. G., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60547-3 · Cited by 1,229

Deep brain stimulation for Parkinson’s disease

Benabid, A. L. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.11.001 · Cited by 1,047

Spinal Cord Injury Facts and Figures at a Glance

(2013) · Journal of Spinal Cord Medicine · doi:10.1179/1079026813z.000000000136 · Cited by 900

Translational principles of deep brain stimulation

Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853

Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease

Stefani, A., Lozano, A. M., Peppe, A., Stanzione, P., Galati, S., Tropepi, D., Pierantozzi, M., Brusa, L., Scarnati, E., & Mazzone, P. (2007) · Brain · doi:10.1093/brain/awl346 · Cited by 805

[Control of walking and running by means of electric stimulation of the midbrain].

Shik, M. L., Fv, S., & Gn, O. (1966) · PubMed · Cited by 760

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

Courtine, G., Gerasimenko, Y., van den Brand, R., Yew, A., Musienko, P., Zhong, H., Song, B., Ao, Y., Ichiyama, R. M., Lavrov, I., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2401 · Cited by 706

Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury

Angeli, C. A., Boakye, M., Morton, R. A., Vogt, J., Benton, K., Chen, Y., Ferreira, C. K., & Harkema, S. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803588 · Cited by 670

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

Gill, M. L., Grahn, P. J., Calvert, J. S., Linde, M. B., Lavrov, I. A., Strommen, J. A., Beck, L. A., Sayenko, D. G., Van Straaten, M. G., Drubach, D. I., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0175-7 · Cited by 574 · cited 1×

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

Hirsch, É. C., Graybiel, A. M., Duyckaerts, C. J., & Javoy-Agid, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5976 · Cited by 554

Distribution of Networks Generating and Coordinating Locomotor Activity in the Neonatal Rat Spinal CordIn Vitro: A Lesion Study

Kjærulff, O., & Kiehn, O. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05777.1996 · Cited by 521

The use of pigs in neuroscience: Modeling brain disorders

Lind, N. M., Moustgaard, A., Jelsing, J., Vajta, G., Cumming, P. D., & Hansen, A. K. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.003 · Cited by 515

Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease

Ferraye, M., Debu, B. H. G., Fraix, V., Goetz, L., Ardouin, C., Yelnik, J., Henry-Lagrange, C., Seigneuret, É., Piallat, B., Krack, P., et al. (2009) · Brain · doi:10.1093/brain/awp229 · Cited by 475

Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease

Plaha, P., & Gill, S. S. (2005) · Neuroreport · doi:10.1097/01.wnr.0000187637.20771.a0 · Cited by 451

Midbrain circuits that set locomotor speed and gait selection

Caggiano, V., Leiras, R., Goñi-Erro, H., Masini, D., Bellardita, C., Bouvier, J., Caldeira, V., Fisone, G., & Kiehn, O. (2018) · Nature · doi:10.1038/nature25448 · Cited by 447

Unilateral pedunculopontine stimulation improves falls in Parkinson's disease

Moro, E., Hamani, C., Poon, Y., Alkhairallah, T. S., Dostrovsky, J. O., Hutchison, W. D., & Lozano, A. M. (2009) · Brain · doi:10.1093/brain/awp261 · Cited by 424

Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction

Takakusaki, K., Habaguchi, T., Ohtinata-Sugimoto, J., Saitoh, K., & Sakamoto, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00095-2 · Cited by 423

Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease

Mazzone, P. A. M., Lozano, A. M., Stanzione, P., Galati, S., Scarnati, E., Peppe, A., & Stefani, A. (2005) · Neuroreport · doi:10.1097/01.wnr.0000187629.38010.12 · Cited by 420

Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia

Roseberry, T. K., Lee, A. M., Lalive, A. L., Wilbrecht, L., Bonci, A., & Kreitzer, A. C. (2016) · Cell · doi:10.1016/j.cell.2015.12.037 · Cited by 390

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324

Stereotaxic atlas of the pig brain

Félix, B., Leger, M. E., Albe-Fessard, D., Marcilloux, J.-C., Rampin, O., Laplace, J.-P., Duclos, A., Fort, F., Gougis, S., Costa, M., et al. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00012-x · Cited by 317

Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials

Minassian, K., Jilge, B., Rattay, F., Pinter, M. M., Binder, H., Gerstenbrand, F., & Dimitrijevic, M. R. (2004) · Spinal Cord · doi:10.1038/sj.sc.3101615 · Cited by 307

Mechanisms and Targets of Deep Brain Stimulation in Movement Disorders

Johnson, M. D., Miocinovic, S., McIntyre, C. C., & Vitek, J. L. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.01.010 · Cited by 302

Imaging human supraspinal locomotor centers in brainstem and cerebellum

Jahn, K., Deutschlander, A. B., Stephan, T., Kalla, R., Wiesmann, M., Strupp, M. L., & Brandt, T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.047 · Cited by 299

Initiation of locomotion in mammals

JORDAN, L. M. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09040.x · Cited by 289

Closed-loop Neurostimulation: The Clinical Experience

Sun, F. T., & Morrell, M. J. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0280-3 · Cited by 288

The pig model in brain imaging and neurosurgery

Sauleau, P., Lapouble, E., Val‐Laillet, D., & Malbert, C. (2009) · animal · doi:10.1017/s1751731109004649 · Cited by 253

Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review

Thevathasan, W., Debu, B. H. G., Aziz, T. Z., Bloem, B. R., Blahak, C., Butson, C. R., Czernecki, V., Foltynie, T., Fraix, V., Grabli, D., et al. (2017) · Movement Disorders · doi:10.1002/mds.27098 · Cited by 237

Does Functional Electrical Stimulation for Foot Drop Strengthen Corticospinal Connections?

Everaert, D. G., Thompson, A. K., Chong, S. L., et al. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968309349939 · Cited by 227

Balance and Ambulation Improvements in Individuals With Chronic Incomplete Spinal Cord Injury Using Locomotor Training–Based Rehabilitation

Harkema, S. J., Schmidt-Read, M., Lorenz, D. J., Edgerton, V. R., & Behrman, A. L. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.01.024 · Cited by 226

Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus

García‐Rill, E., Houser, C. R., Skinner, R. D., Smith, W. L., & Woodward, D. J. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90208-5 · Cited by 226

Transcutaneous Spinal Cord Stimulation Restores Hand and Arm Function After Spinal Cord Injury

İnanıcı, F., Brighton, L. N., Samejima, S., Hofstetter, C. P., & Moritz, C. T. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3049133 · Cited by 219

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury.

Wenger, N., Moraud, E. M., Raspopovic, S., Bonizzato, M., DiGiovanna, J., Musienko, P., Morari, M., Micera, S., & Courtine, G. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008325 · Cited by 209

Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review

Collomb‐Clerc, A., & Welter, M. (2015) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2015.07.001 · Cited by 200

Distinct contributions of mesencephalic locomotor region nuclei to locomotor control in the freely behaving mouse

Josset, N., Roussel, M., Lemieux, M., Lafrance-Zoubga, D., Rastqar, A., & Bretzner, F. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.007 · Cited by 194

Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia

Gad, P. N., Gerasimenko, Y., Zdunowski, S., Turner, A. E., Sayenko, D. G., Lu, D. C.-T., & Edgerton, V. R. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00333 · Cited by 172

Engaging Cervical Spinal Cord Networks to Reenable Volitional Control of Hand Function in Tetraplegic Patients

Lu, D. C.-T., Edgerton, V. R., Modaber, M., AuYong, N., Morikawa, E., Zdunowski, S., Sarino, M. E., Sarrafzadeh, M., Nuwer, M. R., Roy, R. R., et al. (2016) · Neurorehabilitation and neural repair · doi:10.1177/1545968316644344 · Cited by 170

And yet it moves: Recovery of volitional control after spinal cord injury

Taccola, G., Sayenko, D., Gad, P., Gerasimenko, Y., & Edgerton, V. R. (2018) · Progress in neurobiology · doi:10.1016/j.pneurobio.2017.10.004 · Cited by 166

Deep brain stimulation in neurological diseases and experimental models: From molecule to complex behavior

Gubellini, P., Salin, P., Goff, L. K., & Baunez, C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.06.003 · Cited by 165

A Novel Porcine Model of Traumatic Thoracic Spinal Cord Injury

Lee, J. H. T., Jones, C. F., Okon, E. B., Anderson, L., Tigchelaar, S., Kooner, P., Godbey, T., Chua, B. A., Gray, G., Hildebrandt, R., et al. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2386 · Cited by 153

Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease

Lee, K. H., Blaha, C. D., Harris, B. T., Cooper, S., Hitti, F. L., Leiter, J. C., Roberts, D. W., & Kim, U. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04638.x · Cited by 144

Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation in Humans with Tetraplegia

Benavides, F. D., Jo, H. J., Lundell, H., Edgerton, V. R., Gerasimenko, Y. P., & Pérez, M. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2374-19.2020 · Cited by 140

Astasia and gait failure with damage of the pontomesencephalic locomotor region

Masdeu, J. C., Alampur, U., Cavaliere, R., & Tavoulareas, G. P. (1994) · Annals of Neurology · doi:10.1002/ana.410350517 · Cited by 135

Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes

Anderson, D. N., Osting, B., Vorwerk, J., Dorval, A. D., & Butson, C. R. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaa14b · Cited by 128

Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats

Bachmann, L. C., Matiş, A., Lindau, N. T., Felder, P., Gullo, M., & Schwab, M. E. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005972 · Cited by 127

Mechanism for Activation of Locomotor Centers in the Spinal Cord by Stimulation of the Mesencephalic Locomotor Region

Noga, B. R., Kriellaars, D. J., Brownstone, R. M., & Jordan, L. M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00034.2003 · Cited by 127

Translational Research in Spinal Cord Injury: A Survey of Opinion from the SCI Community

Kwon, B. K., Hillyer, J. E., & Tetzlaff, W. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2009.1048 · Cited by 124

Initiation of Locomotor Activity in Spinal Cats by Epidural Stimulation of the Spinal Cord

Gerasimenko, Y. P., Avelev, V. D., Nikitin, O. A., & Lavrov, I. A. (2003) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1022199214515 · Cited by 110

Functional diversity for body actions in the mesencephalic locomotor region

Ferreira-Pinto, M. J., Kanodia, H., Falasconi, A., Sigrist, M., Esposito, M. S., & Arber, S. (2021) · Cell · doi:10.1016/j.cell.2021.07.002 · Cited by 105

Modulation of motor behavior by the mesencephalic locomotor region

Dautan, D., Kovács, A., Bayasgalan, T., Diaz-Acevedo, M. A., Pál, B. Z., & Mena‐Segovia, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109594 · Cited by 100

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

Bretzner, F., & Brownstone, R. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5231-12.2013 · Cited by 99

Long-Term Spinal Cord Stimulation After Chronic Complete Spinal Cord Injury Enables Volitional Movement in the Absence of Stimulation

Pino, I. P., Hoover, C., Venkatesh, S., Ahmadi, A., Sturtevant, D., Patrick, N., Freeman, D., Parr, A. M., Samadani, U., Balser, D. Y., et al. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00035 · Cited by 96

Spinal and Supraspinal Control of the Direction of Stepping during Locomotion

Евгеньевич, М. П., Zelenin, P. V., Lyalka, V. F., Gerasimenko, Y., Orlovsky, G. N., & Deliagina, T. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3757-12.2012 · Cited by 83

Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons

Piallat, B., Chabardès, S., Torres-Martinez, N., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.046 · Cited by 76

Combined Transcutaneous Spinal Stimulation and Locomotor Training to Improve Walking Function and Reduce Spasticity in Subacute Spinal Cord Injury: A Randomized Study of Clinical Feasibility and Efficacy

Estes, S. P., Zarkou, A., Hope, J. M., Suri, C., & Field-Fote, E. C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061167 · Cited by 74

Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: MRI-Based Anatomoclinical Correlations and Optimal Target

Goetz, L., Bhattacharjee, M., Ferraye, M., Fraix, V., Maineri, C., Nosko, D., Fenoy, A. J., Piallat, B., Torres-Martinez, N., Krainik, A., et al. (2018) · Neurosurgery · doi:10.1093/neuros/nyy151 · Cited by 72

A review of methods for achieving upper limb movement following spinal cord injury through hybrid muscle stimulation and robotic assistance

Dunkelberger, N., Schearer, E. M., & O’Malley, M. K. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113274 · Cited by 69

Coupling between lumbar and sacral motor networks in the neonatal rat spinal cord

Cazalets, J., & Bertrand, S. S. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00169.x · Cited by 68

Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region

van der Zouwen, C. I., Boutin, J., Fougère, M., Flaive, A., Vivancos, M., Santuz, A., Akay, T., Sarret, P., & Ryczko, D. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.639900 · Cited by 66

Spinal Cord Stimulation and Augmentative Control Strategies for Leg Movement after Spinal Paralysis in Humans

Minassian, K., & Hofstoetter, U. S. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12530 · Cited by 65

Feasibility and utility of transcutaneous spinal cord stimulation combined with walking-based therapy for people with motor incomplete spinal cord injury

McHugh, L. V., Miller, A. A., Leech, K. A., Salorio, C. F., & Martin, R. H. (2020) · Spinal Cord Series and Cases · doi:10.1038/s41394-020-00359-1 · Cited by 65

Non-invasive approaches to functional recovery after spinal cord injury: Therapeutic targets and multimodal device interventions

Pizzolato, C., Gunduz, M. A., Palipana, D. B., Wu, J., Grant, G. D., Hall, S., Dennison, R., ZAFONTE, R. D., Lloyd, D. G., & Teng, Y. D. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113612 · Cited by 64

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Bonizzato, M., James, N. D., Pidpruzhnykova, G., Pavlova, N., Shkorbatova, P. Y., Baud, L., Martinez‐Gonzalez, C., Squair, J. W., DiGiovanna, J., Barraud, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22137-9 · Cited by 64

Analysis of current density and related parameters in spinal cord stimulation

Wesselink, W. A., Holsheimer, J., & Boom, H. B. K. (1998) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.681186 · Cited by 63

[Structures of the brain stem responsible for evoked locomotion].

Shik, M. L., Fv, S., & Gn, O. (1967) · PubMed · Cited by 59

Therapeutic Stimulation for Restoration of Function After Spinal Cord Injury

Ievins, A., & Moritz, C. T. (2017) · Physiology · doi:10.1152/physiol.00010.2017 · Cited by 58

Clinical deep brain stimulation strategies for orientation-selective pathway activation

Slopsema, J. P., Peña, E., Patriat, R., Lehto, L. J., Gröhn, O. H. J., Mangia, S., Harel, N., Michaeli, S., & Johnson, M. D. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aad978 · Cited by 57

Interaction of paired cortical and peripheral nerve stimulation on human motor neurons

Poon, D. E., Roy, F. D., Gorassini, M. A., & Stein, R. B. (2008) · Experimental Brain Research · doi:10.1007/s00221-008-1334-8 · Cited by 54

Epidural and transcutaneous spinal electrical stimulation for restoration of movement after incomplete and complete spinal cord injury

Mayr, W., Krenn, M. J., & Dimitrijevic, M. R. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000382 · Cited by 53

Complications of epidural spinal stimulation: lessons from the past and alternatives for the future

Taccola, G., Barber, S. M., Horner, P. J., Bazo, H. A. C., & Sayenko, D. G. (2020) · Spinal Cord · doi:10.1038/s41393-020-0505-8 · Cited by 53

Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor Region

Noga, B. R., Turkson, R. P., Xie, S., Taberner, A. M., Pinzón, A., & Hentall, I. D. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00059 · Cited by 50

Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury

Cardenas, D. D., Ditunno, J. F., Graziani, V., McLain, A., Lammertse, D. P., Potter, P. J., Alexander, M. S., Cohen, R., & Blight, A. R. (2013) · Spinal Cord · doi:10.1038/sc.2013.137 · Cited by 48

Epidural and transcutaneous spinal cord stimulation facilitates descending inputs to upper-limb motoneurons in monkeys

Guiho, T., Baker, S. N., & Andrew, J. O. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abe358 · Cited by 48

Activation of Brainstem Neurons During Mesencephalic Locomotor Region-Evoked Locomotion in the Cat

Opriș, I. C., Dai, X., Johnson, D. M. G., Sanchez, F. J., Villamil, L. M., Xie, S., Lee-Hauser, C. R., Chang, S. J., Jordan, L. M., & Noga, B. R. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00069 · Cited by 47

Efficacy and Safety of Pedunculopontine Nuclei (PPN) Deep Brain Stimulation in the Treatment of Gait Disorders: A Meta-Analysis of Clinical Studies

Golestanirad, L., Elahi, B., Graham, S. J., et al. (2015) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2015.318 · Cited by 46

LFP Oscillations in the Mesencephalic Locomotor Region during Voluntary Locomotion

Noga, B. R., Sanchez, F. J., Villamil, L. M., O’Toole, C., Kasicki, S., Olszewski, M., Cabaj, A. M., Majczyński, H., Sławińska, U., & Jordan, L. M. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00034 · Cited by 45

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig

Chang, S. J., Santamaría, A. J., Sanchez, F. J., Villamil, L. M., Saraiva, P. P., Benavides, F. D., Nunez-Gomez, Y., Solano, J. P., Opriș, I. C., Guest, J. D., et al. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.02.017 · Cited by 42

Feasibility of closed-loop controller for righting seated posture after spinal cord injury

Murphy, J. O., BSE, Audu, M. L., Lombardo, L. M., Foglyano, K. M., BSE, & Triolo, R. J. (2014) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2013.09.0200 · Cited by 40

Optical stimulation of neural tissue

Richardson, R. T., Ibbotson, M. R., Thompson, A. C., Wise, A. K., & Fallon, J. B. (2020) · Healthcare Technology Letters · doi:10.1049/htl.2019.0114 · Cited by 40

Normal and pathological neuronal distribution of the human mesencephalic locomotor region

Sébille, S. B., Rolland, A., Faillot, M., et al. (2018) · Movement Disorders · doi:10.1002/mds.27578 · Cited by 38

Spinal Epidural Stimulation Strategies: Clinical Implications of Locomotor Studies in Spinal Rats

Shah, P. K., & Lavrov, I. A. (2017) · The Neuroscientist · doi:10.1177/1073858417699554 · Cited by 37

Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury

Pulverenti, T. S., Zaaya, M., Grabowski, M., Grabowski, E., Islam, M. A., Li, J., Murray, L. M., & Knikou, M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.627975 · Cited by 36

Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation

Chang, S. J., Cajigas, I., Opriș, I. C., Guest, J. D., & Noga, B. R. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00064 · Cited by 34

Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury

Radhakrishna, M., Steuer, I., Prince, F., Roberts, M., Mongeon, D., Kia, M., Holzinger, S. D., Matte, G. G., Vaillancourt, M., & Guertin, P. A. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161227152200 · Cited by 33

Promotion of Recovery From Thoracic Spinal Cord Contusion in Rats by Stimulation of Medullary Raphe or Its Midbrain Input

Hentall, I. D., & Gonzalez, M. M. C. (2011) · Neurorehabilitation and neural repair · doi:10.1177/1545968311425178 · Cited by 31

Spinal cord stimulation for the restoration of bladder function after spinal cord injury

Steadman, C. J., & Grill, W. M. (2020) · Healthcare Technology Letters · doi:10.1049/htl.2020.0026 · Cited by 31

Characterization of Motor and Somatosensory Evoked Potentials in the Yucatan Micropig Using Transcranial and Epidural Stimulation

Benavides, F. D., Santamaría, A. J., Bodoukhin, N., Guada, L. G., Solano, J. P., & Guest, J. D. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4511 · Cited by 27

Dichotomous Locomotor Recoveries Are Predicted by Acute Changes in Segmental Blood Flow after Thoracic Spinal Contusion Injuries in Pigs

Santamaría, A. J., Benavides, F. D., Padgett, K. R., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.6087 · Cited by 27

Neurons labeled from locomotor‐related ventrolateral funiculus stimulus sites in the neonatal rat spinal cord

Antonino-Green, D. M., Cheng, J., & Magnuson, D. S. K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.10081 · Cited by 26

Using EMG to deliver lumbar dynamic electrical stimulation to facilitate cortico-spinal excitability

Taccola, G., Gad, P. N., Culaclii, S., Ichiyama, R. M., Liu, W., & Edgerton, V. R. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.09.013 · Cited by 26

Burst spinal cord stimulation for pain and motor function in Parkinson's disease: A case series

Furusawa, Y., Matsui, A., Kobayashi-Noami, K., Kojima, Y., Tsubouchi, A., Todoroki, D., Abe, K., Ishihara, T., Nishikawa, N., Sakamoto, T., et al. (2020) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2020.100043 · Cited by 25

Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

Wang, M., Jia, L., Wu, X., Sun, Z., Xu, Z., Kong, C., Ma, L., Zhao, R., & Lu, S. (2020) · World Neurosurgery · doi:10.1016/j.wneu.2020.05.029 · Cited by 24

Electromagnetic Fields and Stem Cell Fate: When Physics Meets Biology

Tamrin, S. H., Majedi, F. S., Tondar, M., Sanati‐Nezhad, A., & Hasani‐Sadrabadi, M. M. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2016_4 · Cited by 22

A meta-analysis of the pedunculopontine nucleus deep-brain stimulation effects on Parkinson’s disease

Wang, H., Gao, H., Jiao, T., et al. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000697 · Cited by 20

Deep brain stimulation of the Cuneiform nucleus for levodopa-resistant freezing of gait in Parkinson’s disease: study protocol for a prospective, pilot trial

Chang, S. J., Cajigas, I., Guest, J. D., Noga, B. R., Widerström-Noga, E. G., Haq, I. U., Fisher, L., Luca, C. C., & Jagid, J. R. (2021) · Pilot and Feasibility Studies · doi:10.1186/s40814-021-00855-7 · Cited by 19

Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury

Taccola, G., Gad, P. N., Culaclii, S., Wang, P., Liu, W., & Edgerton, V. R. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113246 · Cited by 18

MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson’s Disease Patient With Levodopa-Resistant Freezing of Gait

Chang, S. J., Cajigas, I., Guest, J. D., Noga, B. R., Widerström-Noga, E. G., Haq, I. U., Fisher, L., Luca, C. C., & Jagid, J. R. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.676755 · Cited by 18

Rostral lumbar segments are the key controllers of hindlimb locomotor rhythmicity in the adult spinal rat

Gerasimenko, Y., Preston, C., Zhong, H., Roy, R. R., Edgerton, V. R., & Shah, P. K. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00810.2018 · Cited by 17

Comparison of operation of spinal locomotor networks activated by supraspinal commands and by epidural stimulation of the spinal cord in cats

Евгеньевич, М. П., Lyalka, V. F., Gorskii, O., Merkulyeva, N. S., Gerasimenko, Y. P., Deliagina, T. G., & Zelenin, P. V. (2020) · The Journal of Physiology · doi:10.1113/jp279460 · Cited by 16

MRI brain templates of the male Yucatan minipig

Norris, C., Lisinski, J. M., McNeil, E. M., VanMeter, J. W., VandeVord, P. J., & LaConte, S. M. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118015 · Cited by 16

Subject-specific computational modeling of DBS in the PPTg area

Verbick, L. Z., Teplitzky, B. A., Yager, P., Hudson, H. M., Brintz, K., Duchin, Y., Harel, N., Vitek, J. L., Baker, K. B., & Johnson, M. D. (2015) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2015.00093 · Cited by 13

Modulation of motor behavior by the mesencephalic locomotor regionPreprint

Dautan, D., Kovács, A., Bayasgalan, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.25.172296 · Cited by 12

In vivo Population Averaged Stereotaxic T2w MRI Brain Template for the Adult Yucatan Micropig

Chang, S. J., Santamaría, A. J., Sanchez, F. J., Villamil, L. M., Saraiva, P. P., Rodriguez, J., Nunez-Gomez, Y., Opriș, I. C., Solano, J. P., Guest, J. D., et al. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.599701 · Cited by 11

The micropig model of neurosurgery and spinal cord injury in experiments of motor control

Noga, B. R., Santamaría, A. J., Chang, S. J., Benavides, F. D., Sanchez, F. J., Villamil, L. M., Saraiva, P. M., Opriș, I. C., Solano, J. P., & Guest, J. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816477-8.00014-4 · Cited by 9

Freely behaving mice can brake and turn during optogenetic stimulation of the Mesencephalic Locomotor RegionPreprint

van der Zouwen, C. I., Boutin, J., Fougère, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.30.404525 · Cited by 7

A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats

Yousefpour, A., & Erfanian, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-82933-7 · Cited by 6

Editorial: Neuromodulatory Control of Spinal Function in Health and Disease

Noga, B. R., Hochman, S., & Hultborn, H. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00084 · Cited by 2

Walking naturally after spinal cord injury using a brain–spine interface

Lorach, H., Galvez, A., Spagnolo, V., Martel, F., Karakas, S., Intering, N., Vat, M., Faivre, O., Harte, C., Komi, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06094-5 · Cited by 631

The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease

Ryczko, D. (2024) · The Neuroscientist · doi:10.1177/10738584221139136 · Cited by 31