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Effect of 12-Week Administration of 20-mg Long-Acting Methylphenidate on Glu/Cr, NAA/Cr, Cho/Cr, and mI/Cr Ratios in the Prefrontal Cortices of School-Age Children in Indonesia: A Study Using 1H Magnetic Resonance Spectroscopy (MRS)
Abstract
Objectives Recent studies on the neurobiology of attention-deficit/hyperactivity disorder (ADHD) have suggested that there is dysregulation of dopamine-mediated neurotransmission, particularly in the prefrontal cortex and basal ganglia, and that treatment with methylphenidate reverses this dysregulation. Using methodology similar to previous studies involving putative markers of brain functioning, we used 1H magnetic resonance spectroscopy to study the effect of 12-week treatment with daily 20-mg long-acting methylphenidate on the glutamate/creatine, N-acetyl-aspartate/creatine, choline/creatine, and myoinositol/creatine ratios in the prefrontal cortices of medication-naive children with ADHD. Method This was a prospective study, using a pretest and posttest design, on a single group of 21 children (mean age, 8.52 years; 17 males and 4 females) with a diagnosis of ADHD. A low time echo (TE) magnetic resonance spectroscopic scans sampled voxels of interest (1.5 × 1.5 × 2.0) from both the right and left prefrontal cortices. Results After treatment, the N-acetyl-aspartate/creatine ratio increased 18.8% in the right prefrontal cortex (P = 0.001) and 10% in the left prefrontal cortex (P = 0.007); the glutamate/creatine ratio decreased 15% in the right prefrontal cortex (P = 0.005) and 14.1% in the left prefrontal cortex (P = 0.005); the choline/creatine ratio decreased 12.4% in the right prefrontal cortex (P = 0.037) and 16% in the left prefrontal cortex (P = 0.006); and the myoin…
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“In addition, stimulants also decrease glutamate levels in the PFC of children with ADHD (Wiguna et al, 2012).”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Wiguna et al, 2012
In the citing paper
“Results of the few studies that have examined the effect of stimulants on left PFC glutamate levels are inconsistent and have shown that stimulants either decrease (Wiguna et al, 2012) or have no effect (Carrey et al, 2002; Husarova et al, 2014b) on glutamate concentrations.”
From Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties (2017) · cites this paper as Wiguna et al, 2012
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Research works printed but not linked: 12
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Dosage of methylphenidate and traumatic brain injury in ADHD: a population-based study in Taiwan
Liao, Y.-T., Yang, Y.-H., Kuo, T.-Y., Liang, H.-Y., Huang, K.-Y., Wang, T.-N., Lee, Y., McIntyre, R. S., & Chen, V. C.-H. (2018) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1042-7 · Cited by 24
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Self-citation
Metadata
- Authors
- Wiguna, T., Guerrero, A. P. S., Wibisono, S., & Sastroasmoro, S.
- Venue
- Clinical Neuropharmacology
- Published
- 2012-03
- Volume
- 35
- Issue
- 2
- Pages
- 81-85
- ISSN
- 0362-5664
- Cited by
- 46
- References
- 0
- Language
- en
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