Online effects of transcranial direct current stimulation in real time on human prefrontal and striatal metabolites
Open accessAbstract
Background Studies have reported that transcranial direct current stimulation (tDCS) can modulate human behaviors, symptoms, and neural activity; however, the neural effects during stimulation are unknown. Most studies compared the effects of tDCS before and after stimulation. The objective of our study was to measure the neurobiological effect of a single tDCS dose during stimulation.Methods We conducted an online and offline protocol combining tDCS and magnetic resonance spectroscopy (MRS) in 17 healthy participants. We applied anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS over the right DLPFC for 30 minutes, one of the most common montages used with tDCS. We collected MRS measurements in the left DLPFC and left striatum during tDCS and an additional MRS measurement in the left DLPFC immediately after the end of stimulation.Results During stimulation, active tDCS, as compared with sham tDCS, elevated prefrontal N-acetylaspartate and striatal glutamate + glutamine but did not induce significant differences in prefrontal or striatal gamma-aminobutyric acid level. Immediately after stimulation, active tDCS, as compared with sham tDCS, did not significantly induce differences in glutamate + glutamine, N-acetylaspartate, or gamma-aminobutyric acid levels in the left DLPFC.Conclusions These observations indicate that tDCS over the DLPFC has fast excitatory effects, acting on prefrontal and striatal transmissions, and these effects are short lived. One may postulate that repeated sessions of tDCS might induce similar longer lasting effects of elevated prefrontal N-acetylaspartate and striatal glutamate + glutamine levels, which may contribute to its behavioral and clinical effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
tDCS can modulate both neurotransmission and network connectivity patterns in the subcortical and cortical components of CSTC loops when targeting the salience network via the dlPFC.
“Taken together, these findings suggest that tDCS can indeed modulate both neurotransmission and network connectivity patterns in the subcortical as well as the cortical components of CSTC loops when targeting the SN (i.e., via the dlPFC).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Hone-Blanchet et al., 2015
Active but not sham dlPFC-tDCS increases levels of glutamate and glutamine in the striatum and N-acetylaspartate in the dlPFC.
“Finally, a recent study using magnetic resonance spectroscopy (MRS) has for the first time directly demonstrated that active but not sham dlPFC-tDCS (anodal left, cathodal right) increases levels of glutamate and glutamine in the striatum as well as N-acetylaspartate in the dlPFC itself (Hone-Blanchet et al., 2015).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Hone-Blanchet et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617 · see citing works
Gandiga, P., Hummel, F., & Cohen, L. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.12.003 · Cited by 1,721 · see citing works
Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., Edwards, D. J., Valero-Cabre, A., Rotenberg, A., Pascual-Leone, A., et al. (2012) · Brain stimulation · doi:10.1016/j.brs.2011.03.002 · Cited by 1,445 · see citing works
N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,413 · see citing works
Liebetanz, D. (2002) · Brain · doi:10.1093/brain/awf238 · Cited by 1,383 · see citing works
Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
Urenjak, J., Williams, S. R., Gadian, D. G., & Noble, M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00981.1993 · Cited by 995 · see citing works
Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation
Stagg, C. J., Best, J. G., Stephenson, M. C., O’Shea, J., Wylezinska, M., Kincses, Z. T., Morris, P. G., Matthews, P. M., & Johansen‐Berg, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4432-08.2009 · Cited by 942 · see citing works
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Corticostriatal connectivity and its role in disease
Shepherd, G. M. G. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3469 · Cited by 824 · see citing works
Kelley, A. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.016 · Cited by 773 · see citing works
Schizophrenia, neuroimaging and connectomics
Fornito, A., Zalesky, A., Pantelis, C., & Bullmore, E. T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.090 · Cited by 716 · see citing works
Edden, R. A. E., Puts, N. A. J., Harris, A. D., Barker, P. B., & Evans, J. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24478 · Cited by 625 · see citing works
Self-citationHorvath, J. C., Forte, J. D., & Carter, O. (2015) · Brain Stimulation · doi:10.1016/j.brs.2015.01.400 · Cited by 609 · see citing works
The Sertraline vs Electrical Current Therapy for Treating Depression Clinical Study
Brunoni, A. R., Valiengo, L. D. C. L., Baccaro, A., Zanao, T. A., de Oliveira, J. F., Goulart, A. C., Boggio, P. S., Lotufo, P. A., Benseñor, I. M., & Fregni, F. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.32 · Cited by 602 · see citing works
Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
Mullins, P. G., McGonigle, D. J., Tuura, R., Puts, N. A. J., Vidyasagar, R., Evans, J., & Edden, R. A. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.004 · Cited by 555 · see citing works
Self-citationHorvath, J. C., Forte, J. D., & Carter, O. L. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.11.021 · Cited by 524 · see citing works
Brunelin, J., Mondino, M., Gassab, L., Haesebaert, F., Gaha, L., Suaud-Chagny, M.-F., Saoud, M., Mechri, A., & Poulet, E. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11071091 · Cited by 520 · see citing works
Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial
Loo, C. K., Alonzo, A., Martin, D., Mitchell, P. B., Galvez, V., & Sachdev, P. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.097634 · Cited by 455 · see citing works
Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea
Prasad, B., Radulovacki, M. G., & Carley, D. W. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00001 · Cited by 424 · see citing works
Zaehle, T., Sandmann, P., Thorne, J. D., Jäncke, L., & Herrmann, C. S. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-2 · Cited by 403 · see citing works
George, M. S., & Aston‐Jones, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.87 · Cited by 402 · see citing works
In vivo magnetic resonance spectroscopy of GABA: A methodological review
Puts, N. A. J., & Edden, R. A. E. (2011) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2011.06.001 · Cited by 394 · see citing works
Self-citationConsolidation of Human Motor Cortical Neuroplasticity by D-Cycloserine
Nitsche, M. A., Jaussi, W., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300517 · Cited by 385 · see citing works
GABAergic modulation of DC stimulation‐induced motor cortex excitability shifts in humans
Nitsche, M. A., Liebetanz, D., Schlitterlau, A., Henschke, U., Fricke, K., Frommann, K., Lang, N., Henning, S., Paulus, W., & Tergau, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03398.x · Cited by 368 · see citing works
Wilson, M., Reynolds, G., Kauppinen, R. A., Arvanitis, T. N., & Peet, A. C. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22579 · Cited by 327 · see citing works
Harris, A. D., Puts, N. A. J., & Edden, R. A. E. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24903 · Cited by 298 · see citing works
Self-citationClark, V. P., Coffman, B. A., Trumbo, M., & Gasparovic, C. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.244 · Cited by 284 · see citing works
Effects of non-invasive neurostimulation on craving: A meta-analysis
Jansen, J. M., Daams, J. G., Koeter, M. W. J., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.009 · Cited by 284 · see citing works
In vivo magnetic resonance spectroscopy: basic methodology and clinical applications
van der Graaf, M. (2009) · European Biophysics Journal · doi:10.1007/s00249-009-0517-y · Cited by 274 · see citing works
Steen, R. G., Hamer, R. M., & Lieberman, J. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300850 · Cited by 254 · see citing works
Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.
Kalivas, P. W., Duffy, P., & Barrow, J. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20732-7 · Cited by 215 · see citing works
Glutamate Metabolism in Major Depressive Disorder
Abdallah, C. G., Jiang, L., De Feyter, H. M., Fasula, M., Krystal, J. H., Rothman, D. L., Mason, G. F., & Sanacora, G. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010067 · Cited by 200 · see citing works
Gruber, S., Frey, R., Mlynárik, V., Stadlbauer, A., Heiden, A. M., Kasper, S. F., Kemp, G. J., & Moser, E. (2003) · Investigative Radiology · doi:10.1097/01.rli.0000073446.43445.20 · Cited by 164 · see citing works
Metuki, N., Sela, T., & Michal Lavidor, B. (2012) · Brain stimulation · doi:10.1016/j.brs.2012.03.002 · Cited by 163 · see citing works
Fregni, F., Potvin, K., Silva, D., Wang, X., Lenkinski, R. E., Freedman, S. D., & Pascual‐Leone, Á. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.08.002 · Cited by 107 · see citing works
Nihonsugi, T., Ihara, A. S., & Haruno, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3885-14.2015 · Cited by 91 · see citing works
Punwani, S., Ordidge, R. J., Cooper, C. E., Amess, P., & Clemence, M. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199810)11:6 · Cited by 74 · see citing works
Ertuğrul, A., Salancı, B. V., Başar, K., Oğuz, K. K., Demir, B., Ergün, E. L., Şentürk, S., Erbaş, B., Cila, A., & Uluğ, B. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.04.007 · Cited by 67 · see citing works
Foerde, K., Poldrack, R. A., Knowlton, B. J., Sabb, F. W., Bookheimer, S. Y., Bilder, R. M., Guthrie, D., Granholm, E., Nuechterlein, K. H., Marder, S. R., et al. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.1.100 · Cited by 67 · see citing works
Wiguna, T., Guerrero, A. P. S., Wibisono, S., & Sastroasmoro, S. (2012) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3182452572 · Cited by 53 · see citing works
Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate
Kronenberg, G., Ende, G., Alm, B., Deuschle, M., Heuser, I., & Colla, M. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0810-2 · Cited by 33 · see citing works
N-Acetyl-Aspartate Level is Decreased in the Prefrontal Cortex in Subjects At-Risk for Schizophrenia
Mondino, M., Brunelin, J., & Saoud, M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00099 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A. R., Chen, R. E., Cohen, L. G., Dowthwaite, G., Ellrich, J., Flöel, A., et al. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.001 · Cited by 1,311 · see citing works
Peters, S. K., Dunlop, K., & Downar, J. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00104 · Cited by 611 · see citing works
“Within nodes of the SN, volumetric changes have been identified in the ACC, striatum and thalamus (Gilbert et al., 2008; Hoexter et al., 2012; Hou et al., 2013; Atmaca et al., 2016).”
BackgroundMethodReed, T. L., & Kadosh, R. C. (2018) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-018-0181-4 · Cited by 237 · see citing works
Fonteneau, C., Redoute, J., Haesebaert, F., Le Bars, D., Costes, N., Suaud-Chagny, M.-F., & Brunelin, J. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy093 · Cited by 198 · see citing works
tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults
Antonenko, D., Schubert, F., Bohm, F., Ittermann, B., Aydın, S., Hayek, D., Grittner, U., & Flöel, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0079-17.2017 · Cited by 143 · see citing works
Cognitive Effects of Transcranial Direct Current Stimulation in Healthy and Clinical Populations
Berryhill, M. E., & Martin, D. M. (2018) · Journal of Ect · doi:10.1097/yct.0000000000000534 · Cited by 89 · see citing works
Bunai, T., Hirosawa, T., Kikuchi, M., Fukai, M., Yokokura, M., Ito, S., Takata, Y., Terada, T., & Ouchi, Y. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.12.010 · Cited by 72 · see citing works
Pol, F., Salehinejad, M. A., Baharlouei, H., & Nitsche, M. A. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00245-2 · Cited by 63 · see citing works
Rosa, E. D., Brigadoi, S., Cutini, S., Tarantino, V., Dell’Acqua, R., Mapelli, D., Braver, T. S., & Vallesi, A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116062 · Cited by 59 · see citing works
Pozdniakov, I., Vorobiova, A. N., Galli, G., Rossi, S., & Feurra, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-83449-w · Cited by 59 · see citing works
Transcranial Electrical Stimulation as a Tool to Enhance Attention
Reteig, L. C., Talsma, L. J., van Schouwenburg, M. R., & Slagter, H. A. (2017) · Journal of Cognitive Enhancement · doi:10.1007/s41465-017-0010-y · Cited by 57 · see citing works
Zortéa, M., Ramalho, L., Alves, R. L., Alves, C. F. D. S., Braulio, G., Torres, I. L. D. S., Fregni, F., & Caumo, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01218 · Cited by 57 · see citing works
The impact of a lack of mathematical education on brain development and future attainment
Zacharopoulos, G., Sella, F., & Kadosh, R. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013155118 · Cited by 58 · see citing works
Wörsching, J., Padberg, F., Ertl-Wagner, B. B., Kumpf, U., Kirsch, B., & Keeser, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.001 · Cited by 52 · see citing works
Mishra, R. K., & Thrasher, T. A. (2020) · Gait & Posture · doi:10.1016/j.gaitpost.2020.11.012 · Cited by 50 · see citing works
Li, L. M., Violante, I. R., Leech, R., Hampshire, A., Opitz, A., McArthur, D. A., Carmichael, D. W., & Sharp, D. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.069 · Cited by 45 · see citing works
Heimrath, K., Brechmann, A., Blobel-Lüer, R., Stadler, J., Budinger, E., & Zaehle, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-77111-0 · Cited by 45 · see citing works
Meyer, B., Mann, C., Götz, M., Gerlicher, A., Saase, V., Yuen, K. S. L., Aedo-Jury, F., Gonzalez-Escamilla, G., Stroh, A., & Kalisch, R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.3128-18.2019 · Cited by 43 · see citing works
Mechanisms of Acute and After Effects of Transcranial Direct Current Stimulation
Bikson, M., Paulus, W., Esmaeilpour, Z., Kronberg, G., & Nitsche, M. A. (2019) · Springer eBooks · doi:10.1007/978-3-319-95948-1_3 · Cited by 40 · see citing works
Chang, C.-C., Kao, Y., Chao, C.-Y., Tzeng, N., & Chang, H. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109715 · Cited by 38 · see citing works
Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging
Brem, A., & Sensi, S. L. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.09.009 · Cited by 37 · see citing works
Dickler, M., Lenglos, C., Renauld, E., Ferland, F., Edden, R. A. E., Leblond, J., & Fecteau, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.002 · Cited by 35 · see citing works
Self-citationLin, Y., Chang, C.-C., Huang, C. C., Tzeng, N., Kao, Y., & Chang, H. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.030 · Cited by 35 · see citing works
Stimulating aged brains with transcranial direct current stimulation: Opportunities and challenges.
Habich, A., Fehér, K., Antonenko, D., Boraxbekk, C., Flöel, A., Nissen, C., Siebner, H., Thielscher, A., & Klöppel, S. (2020) · Psychiatry research. Neuroimaging · doi:10.1016/j.pscychresns.2020.111179 · Cited by 32 · see citing works
Predicting learning and achievement using GABA and glutamate concentrations in human development
Zacharopoulos, G., Sella, F., Kadosh, K. C., Hartwright, C. E., Emir, U. E., & Kadosh, R. C. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001325 · Cited by 31 · see citing works
Gann, M. A., King, B. R., Dolfen, N., Veldman, M. P., Chan, K. L., Puts, N. A. J., Edden, R. A. E., Davare, M., Swinnen, S. P., Mantini, D., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118158 · Cited by 27 · see citing works
Self-citationTranscranial Direct Current Stimulation Effects on Semantic Processing in Healthy Individuals
Joyal, M., & Fecteau, S. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.05.003 · Cited by 27 · see citing works
Self-citationFischell, S. A., Ross, T. J., Deng, Z., Salmeron, B. J., & Stein, E. A. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.020 · Cited by 22 · see citing works
Jeong, H. S., Oh, J. K., Choi, E. K., Im, J. J., Yoon, S. J., Knotková, H., Bikson, M., Song, I., Lee, S. H., & Chung, Y. (2021) · Journal of Behavioral Addictions · doi:10.1556/2006.2020.00092 · Cited by 24 · see citing works
Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study
Dennison, O., Gao, J., Lim, L. W., Stagg, C. J., & Aquili, L. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.12.001 · Cited by 25 · see citing works
Chang, C.-C., Lin, Y., Tzeng, N., Kao, Y., & Chang, H. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.008 · Cited by 23 · see citing works
Cheng, J., Zhao, X., Qiu, J. H., Jiang, Y., Ren, J., Sun, S.-Y., Wang, R., & Su, C. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.01.014 · Cited by 24 · see citing works
Hadoush, H., Banihani, S. A., Khalil, H. W., Al-Qaisi, Y., Al‐Sharman, A., & Al-Jarrah, M. D. (2018) · Neurodegenerative Disease Management · doi:10.2217/nmt-2017-0048 · Cited by 23 · see citing works
Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study
Nwaroh, C., Giuffre, A., Cole, L., Bell, T., Carlson, H. L., MacMaster, F. P., Kirton, A., & Harris, A. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0222620 · Cited by 23 · see citing works
The involvement of the striatum in decision making
Goulet, J., Labbé, S., & Fecteau, S. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/sfecteau · Cited by 22 · see citing works
Self-citationWörsching, J., Padberg, F., Goerigk, S. A., Heinz, I., Bauer, C., Plewnia, C., Hasan, A., Ertl-Wagner, B. B., & Keeser, D. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.05.001 · Cited by 22 · see citing works
Mezger, E., Rauchmann, B., Brunoni, A. R., Bulubas, L., Thielscher, A., Werle, J., Mortazavi, M., Karali, T., Stoecklein, S., Ertl-Wagner, B. B., et al. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01177-0 · Cited by 22 · see citing works
Tuura, R., Warnock, G., Ametamey, S. M., Treyer, V., Noeske, R., Buck, A., & Sommerauer, M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.017 · Cited by 20 · see citing works
Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1
Garg, S., Williams, S., Jung, J., Pobric, G., Nandi, T., Lim, B., Vassallo, G., Green, J., Evans, D. G., Stagg, C. J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21907-9 · Cited by 19 · see citing works
No Effects of Anodal tDCS on Local GABA and Glx Levels in the Left Posterior Superior Temporal Gyrus
Dwyer, G. E., Craven, A. R., Hirnstein, M., Kompus, K., Aßmus, J., Ersland, L., Hugdahl, K., & Grüner, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2018.01145 · Cited by 19 · see citing works
Lengu, K., Ryan, S. E., Peltier, S., Tyszkowski, T., Kairys, A. E., Giordani, B., & Hampstead, B. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-201091 · Cited by 18 · see citing works
Schuerbeek, A. V., Vanderhasselt, M., Baeken, C., Pierre, A., Smolders, I. J., Waes, V. V., & Bundel, D. D. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.01.005 · Cited by 18 · see citing works
Ryan, K., Wawrzyn, K., Gati, J. S., Chronik, B. A., Wong, D. Y., Duggal, N., & Bartha, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198053 · Cited by 18 · see citing works
Choi, C., Iordanishvili, E., Shah, N. J., & Binkofski, F. (2021) · Human Brain Mapping · doi:10.1002/hbm.25388 · Cited by 18 · see citing works
Tremblay, S., Lafleur, L.-P., Proulx, S., Beaulé, V., Latulipe-Loiselle, A., Doyon, J., Marjańska, M., & Théoret, H. (2016) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-150569 · Cited by 18 · see citing works
Zappasodi, F., Musumeci, G., Navarra, R., Lazzaro, V. D., Caulo, M., & Uncini, A. (2017) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2017.09.002 · Cited by 17 · see citing works
Habich, A., Slotboom, J., Peter, J., Wiest, R., & Klöppel, S. (2020) · Neural Plasticity · doi:10.1155/2020/8896791 · Cited by 17 · see citing works
Plitman, E., Chavez, S., Nakajima, S., Iwata, Y., Chung, J. K., Caravaggio, F., Kim, J. N., Alshehri, Y., Chakravarty, M. M., Luca, V. D., et al. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.01.004 · Cited by 16 · see citing works
Hirtz, R., Weiß, T., Huonker, R., & Witte, O. W. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24258 · Cited by 16 · see citing works
Gomis-Vicent, E., Thoma, V., Turner, J. J., Hill, K. P., & Pascual‐Leone, Á. (2019) · American Journal on Addictions · doi:10.1111/ajad.12945 · Cited by 16 · see citing works
Chang, C.-C., Kao, Y., Chao, C.-Y., Tzeng, N., & Chang, H. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa063 · Cited by 16 · see citing works
Ji, Y., Ni, X., Zheng, K., Jiang, Y., Ren, C., Zhu, H., Xiao, M., & Wang, T. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110747 · Cited by 16 · see citing works
Wu, J., Zhuang, S., Zhang, X., Wang, L., Ma, X., Jin, H., Mao, C., Chen, J., & Liu, C.-F. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107050 · Cited by 14 · see citing works
Marquardt, L., Kusztrits, I., Craven, A. R., Hugdahl, K., Specht, K., & Hirnstein, M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14932 · Cited by 14 · see citing works
Interactions between tDCS treatment and COMT Val158Met in poststroke cognitive impairment
Ai, Y., Liu, Y., Yin, M., Zhang, L., Luo, J., Zhang, S., Huang, L. K., Zhang, C., Liu, G., Fang, J., et al. (2023) · Clinical Neurophysiology · doi:10.1016/j.clinph.2023.12.011 · Cited by 13 · see citing works
Vural, G., Soldini, A., Padberg, F., Karslı, B., Zinchenko, A., Goerigk, S. A., Soutschek, A., Mezger, E., Stoecklein, S., Bulubas, L., et al. (2024) · Human Brain Mapping · doi:10.1002/hbm.70097 · Cited by 13 · see citing works
Bouchard, A. E., Renauld, E., & Fecteau, S. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1229618 · Cited by 12 · see citing works
Self-citationWards, Y., Ehrhardt, S. E., Filmer, H. L., Mattingley, J. B., Garner, K., & Dux, P. E. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad406 · Cited by 11 · see citing works
Hadoush, H., Alqudah, A., Banihani, S. A., Al-Jarrah, M. D., Amro, A., & Aldajah, S. (2021) · Sleep Science · doi:10.5935/1984-0063.20200083 · Cited by 12 · see citing works
Gibson, B. C., Claus, E. D., Sanguinetti, J., Witkiewitz, K. A., & Clark, V. P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104821 · Cited by 12 · see citing works
He, J., Wang, R., Li, J.-Y., Jiang, X., Zhou, C., & Liu, J. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.06.038 · Cited by 11 · see citing works
Baharlouei, H., Salehinejad, M. A., Talimkhani, A., & Nitsche, M. A. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.01.026 · Cited by 10 · see citing works
Fecteau, S. (2022) · The Neuroscientist · doi:10.1177/10738584211067744 · Cited by 10 · see citing works
Self-citationMoslemi, B., Azmodeh, M., Tabatabaei, M., & Vafa, M. A. (2019) · The Neuroscience Journal of Shefaye Khatam · doi:10.29252/shefa.8.1.129 · Cited by 9 · see citing works
Kraus, C., Hahn, A., Sigurdardottir, H., Spurny‐Dworak, B., Wadsak, W., Mitterhauser, M., Hacker, M., Kasper, S. F., & Lanzenberger, R. R. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00195-4 · Cited by 9 · see citing works
Razza, L. B., da Silva, P. H. R., Busatto, G. F., Duran, F., Pereira, J., Smet, S. D., Klein, I., Zanao, T. A., Luethi, M. S., Baeken, C., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102410 · Cited by 8 · see citing works
Dwyer, G. E., Hugdahl, K., Specht, K., & Grüner, R. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666181130103559 · Cited by 8 · see citing works
Polizzotto, N. R., Ramakrishnan, N., & Cho, R. Y. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00939 · Cited by 8 · see citing works
Wang, Y., Cao, Q., Wei, C., Xu, F., Zhang, P., Zeng, H., Shao, Y., Weng, X., & Meng, R. (2023) · Brain Sciences · doi:10.3390/brainsci13060933 · Cited by 7 · see citing works
Dumont, L., Mouderrib, S. E., & Théoret, H. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-180872 · Cited by 7 · see citing works
Chhabra, H., Thimmashetty, V. H., Shivakumar, V., Venkatasubramanian, G., & Narayanaswamy, J. C. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.14 · Cited by 7 · see citing works
The relation between parietal GABA concentration and numerical skills
Zacharopoulos, G., Sella, F., Emir, U. E., & Kadosh, R. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-95370-3 · Cited by 6 · see citing works
Transcranial Direct Current Stimulation (tDCS)
Ferrucci, R., Ruggiero, F., Mameli, F., Bocci, T., & Priori, A. (2023) · Neuromethods · doi:10.1007/978-1-0716-3263-5_11 · Cited by 7 · see citing works
Razza, L. B., Buchpiguel, C. A., Smet, S. D., Klein, I., Baeken, C., Galhardoni, R., Vanderhasselt, M., & Brunoni, A. R. (2021) · Trends in Psychiatry and Psychotherapy · doi:10.47626/2237-6089-2020-0110 · Cited by 6 · see citing works
tDCS-Pharmacotherapy Interactions
Kuo, M., & Nitsche, M. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-76136-3_38 · Cited by 6 · see citing works
The impact of brain morphometry on tDCS effects on GABA levels
Bouchard, A. E., Dickler, M., Renauld, E., Lenglos, C., Ferland, F., Edden, R. A. E., Rouillard, C., Leblond, J., & Fecteau, S. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.10.013 · Cited by 5 · see citing works
Self-citationZacharopoulos, G., Sella, F., Emir, U. E., & Kadosh, R. C. (2023) · eLife · doi:10.7554/elife.84086 · Cited by 6 · see citing works
Azarnia, S., Ezzati, K., Saberi, A., Naghdi, S., Abdollahi, I., & Jaberzadeh, S. J. (2023) · Brain Sciences · doi:10.3390/brainsci13071100 · Cited by 4 · see citing works
Tuning noninvasive brain stimulation with MRI to cope with intersubject variability
Habich, A., Canals, S., & Klöppel, S. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000353 · Cited by 4 · see citing works
Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms
Bulubas, L., Mezger, E., Keeser, D., Padberg, F., & Brunoni, A. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00031-7 · Cited by 4 · see citing works
Kortteenniemi, A., Ortega‐Alonso, A., Javadi, A., Tolmunen, T., Ali-Sisto, T., Kotilainen, T., Wikgren, J., Karhunen, L. J., Velagapudi, V., & Lehto, S. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00403 · Cited by 4 · see citing works
Zacharopoulos, G., & Kadosh, R. C. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.10.037 · Cited by 4 · see citing works
Hirtz, R., Weiß, T., Huonker, R., & Witte, O. W. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.031 · Cited by 3 · see citing works
Ji, Q., Mei, S., Cai, L., Elmadhoun, O., Ding, Y., & Geng, X. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1713795 · Cited by 3 · see citing works
Effect of Long-term Transcranial Direct Current Stimulation on Glx and GABA: A Pilot Study
Guan, H., Zheng, Y., Wang, M., Zhang, Y., Wang, M., Chen, W., & Zhang, S. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9175996 · Cited by 3 · see citing works
Ugarte, L. M., Bortolini, T., Yao, B., Mikkelsen, M. E., Monteiro, M., Ferreira, A. C. A. D. F., Bramati, I. E., Melo, B. R. P., Hoefle, S., Meireles, F., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-64876-x · Cited by 4 · see citing works
Pharmacological and Non-pharmacological Interventions
Rudroff, T. (2025) · Springer eBooks · doi:10.1007/978-3-031-89474-9_16 · Cited by 3 · see citing works
Imani, H., & Godde, B. (2025) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000349 · Cited by 2 · see citing works
tDCS and Magnetic Resonance Imaging
Johnstone, A., Hinson, E. L., & Stagg, C. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-33967-2_10 · Cited by 2 · see citing works
tDCS and Magnetic Resonance Imaging
Johnstone, A., Hinson, E. L., & Stagg, C. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-76136-3_8 · Cited by 2 · see citing works
Putzolu, M., Botta, A., Cosentino, C., Mezzarobba, S., Bonassi, G., Ravizzotti, E., Terranova, S., Lagravinese, G., Pelosin, E., & Avanzino, L. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x251327758 · Cited by 2 · see citing works
Vöckel, J., Pokorny, L., Rossberg, R., Geist, N., Kühnel, A., Kroemer, N. B., Seernani, D. P., Klein, C., & Bender, S. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03720-w · Cited by 2 · see citing works
Jin, S., Guo, B., Hao, W., Su, X., Zhang, T., & Liu, C. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00582 · Cited by 1 · see citing works
Ironside, M., & Perlo, S. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0138-9 · Cited by 1 · see citing works
Ryan, K. (2018) · Scholarship@Western (Western University) · Cited by 1 · see citing works
Arora, Y., Dutta, A., & Chowdhury, S. R. (2021) · Biosystems & biorobotics · doi:10.1007/978-3-030-70316-5_114 · Cited by 1 · see citing works
Non-Invasive Brain Stimulation Modulates GABAergic Activity In Neurofibromatosis 1Preprint
Garg, S., Williams, S., Jung, J., Pobric, G., Nandi, T., Lim, B., Vassallo, G., Green, J., Evans, D. G., Stagg, C. J., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-885650/v1
Neuroenhancement of the Executive Functions in Addiction
Balconi, M., & Angioletti, L. (2021) · Advances in mental health and addiction · doi:10.1007/978-3-030-82408-2_5
Razza, L. B. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-30032022-082010
Non-invasive Brain Stimulation Modulates GABAergic Activity in Neurofibromatosis 1Preprint
Garg, S., Williams, S., Jung, J., Pobric, G., Nandi, T., Lim, B., Vassallo, G., Green, J., Evans, D. G., Stagg, C. J., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-885650/v2
- Authors
- Hone-Blanchet, A., Edden, R. A., & Fecteau, S.
- Affiliations
- Johns Hopkins University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Fecteau, Shirley
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 80
- Issue
- 6
- Pages
- 432-438
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5512102
- OpenAlex
- W2185428045
- Cited by
- 110
- References
- 43
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 12 · 2022: 6 · 2021: 21 · 2020: 16 · 2019: 11 · 2018: 18 · 2017: 5 · 2016: 7
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (P41EB015909, R01EB016089)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- transcranial direct current stimulation, dorsolateral prefrontal cortex, striatum, N-acetylaspartate, glutamate/glutamine, GABA, brain metabolites, excitatory effects
- MeSH terms
- Adult, Aspartic Acid, Corpus Striatum, Double-Blind Method, Female, gamma-Aminobutyric Acid, Glutamine, Humans, Male, Magnetic Resonance Spectroscopy, Prefrontal Cortex, Glutamic Acid, Young Adult, Healthy Volunteers, Transcranial Direct Current Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
