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Cited by 121Trace Elements in HealthAutism Spectrum Disorder ResearchHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Serum copper and zinc levels in individuals with autism spectrum disorders

Li, Si-ou, Wang, Jia-liang, Bjørklund, Geir, Zhao, Wei-na, Yin, Chang-hao·2014·NeuroReport
DOI 10.1097/wnr.0000000000000251
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Abstract

Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim of this study was to investigate the serum levels of zinc (Zn) and copper (Cu) in Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed with ASD and 60 healthy sex-matched and age-matched control participants were assessed for serum Zn and Cu content at admission. The severity of ASD was also evaluated using the Childhood Autism Rating Scale (CARS) score. The results indicated that the mean serum Zn levels and Zn/Cu ratio were significantly lower in children with ASD compared with normal cases (P<0.001, respectively), whereas serum Cu levels were significantly higher (P<0.001). There was a significant negative association between Zn/Cu and CARS scores (r=-0.345, P=0.007). On the basis of the receiver operating characteristic curve, the optimal cut-off value of serum levels of Zn/Cu as an indicator for an auxiliary diagnosis of autism was projected to be 0.665, which yielded a sensitivity of 90.0% and a specificity of 91.7%; the area under the curve was 0.968 (95% confidence interval, 0.943-0.993). In conclusion, these results suggested an association between serum levels of Zn and Cu and ASD among Chinese patients, and the Zn/Cu ratio could be considered a biomarker of ASD.

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Crossref · 10.1097/wnr.0000000000000251

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Metadata

Authors
Li, S.-O., Wang, J.-L., Bjørklund, G., Zhao, W.-N., & Yin, C.-H.
Affiliations
Council for Nutritional and Environmental Medicine (NO)
ORCID
Bjørklund, Geir
Venue
NeuroReport
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-10-22
Volume
25
Issue
15
Pages
1216-1220
ISSN
0959-4965 (ISSN-L)
DOI
10.1097/wnr.0000000000000251
OpenAlex
W2134837100
Cited by
121
References
26
Citations by year
2026: 8 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 1
FWCI
8.52
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
autism spectrum disorder, serum zinc, serum copper, copper/zinc ratio, trace elements, biomarkers, autism severity, auxiliary diagnosis, Chinese children
MeSH terms
Blood Chemical Analysis, Child Development Disorders, Pervasive, Child, Preschool, China, Copper, Fasting, Female, Humans, Male, Patient Admission, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity, Zinc, Biomarkers

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