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Cited by 8Pain Mechanisms and TreatmentsAdenosine and Purinergic SignalingIon Channels and Receptors

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Upregulation of P2X2 and P2X3 receptors in rats with hyperalgesia induced by heroin withdrawal

Leng, Changlong, Chen, Lin, Gong, Xiaokang, Ma, Baomiao, Gan, Weimin, Si, Yuanren, Xiao, Huaqiao, Li, Chaoying·2018·NeuroReport
DOI 10.1097/wnr.0000000000001018
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Abstract

Drug dependence and withdrawal syndrome induced by abrupt cessation of opioid administration remain a severe obstacle in the clinical treatment of chronic pain and opioid drug addiction. One of the key symptoms during opioid withdrawal is hyperalgesia. The mechanism of opioid withdrawal-induced hyperalgesia remains unclear. P2X2 and P2X3 receptors, members of P2X receptor subunits, act as the integrator of multiple forms of noxious stimuli and play an important role in nociception transduction of chronic neuropathic and inflammatory pain. The process of P2X2 and P2X3 receptor antagonism inhibits inflammatory hyperalgesia, involving the spinal opioid system. However, the role of P2X receptors involved in opioid withdrawal-induced hyperalgesia has seldom been discussed. To explore the role of P2X2 and P2X3 receptors in the opioid-induced hyperalgesia, heroin self-administration rats were adopted, and the thermal and mechanical nociceptive thresholds were evaluated using the paw withdrawal test after abstinence from heroin for 8 days. In addition, the expressions of P2X2 and P2X3 receptors in dorsal root ganglia were analyzed by immunofluorescence. The results showed that after 8 days of abstinence, heroin self-administration rats showed thermal hyperalgesia and mechanical allodynia. Meanwhile, the expressions of the P2X2 and P2X3 receptors in dorsal root ganglia were increased. These results suggest that upregulation of P2X2 and P2X3 receptors might partially play a role in heroin withdrawal-induced hyperalgesia.

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Metadata

Authors
Leng, C., Chen, L., Gong, X., Ma, B., Gan, W., Si, Y., Xiao, H., & Li, C.
Affiliations
Jianghan University (CN)
ORCID
Venue
NeuroReport
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-05-23
Volume
29
Issue
8
Pages
678-684
ISSN
0959-4965 (ISSN-L)
DOI
10.1097/wnr.0000000000001018
OpenAlex
W2800162166
Cited by
8
References
2
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • China Scholarship Council
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
P2X2 receptor, P2X3 receptor, P2X receptors, opioid withdrawal, heroin withdrawal, thermal hyperalgesia, mechanical allodynia, dorsal root ganglia, nociception, opioid use disorder
MeSH terms
Analgesics, Opioid, Animals, Heroin, Disease Models, Animal, Ganglia, Spinal, Hot Temperature, Heroin Dependence, Hyperalgesia, Male, Self Administration, Substance Withdrawal Syndrome, Touch, Up-Regulation, Rats, Sprague-Dawley, Pain Threshold, Receptors, Purinergic P2X2, Receptors, Purinergic P2X3

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