Cited by 322Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Self‐administration of drugs in animals and humans as a model and an investigative tool

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Panlilio, Leigh V., Goldberg, Steven R.·2007·Addiction

Abstract

Aim To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self‐administration in animals and humans. Background The use of drug self‐administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self‐administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre‐clinical research that also involves screening with a variety of simpler behavioral techniques, drug self‐administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self‐administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self‐administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction.

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Crossref · 10.1111/j.1360-0443.2007.02011.x

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Authors
Panlilio, L. V., & Goldberg, S. R.
Affiliations
National Institutes of Health (US)
Corresponding author
Goldberg, Steven R.
Venue
Addiction
Publisher
Wiley
Published
2007-11-19
Volume
102
Issue
12
Pages
1863-1870
ISSN
  • 0965-2140 (ISSN-L)
  • 1360-0443
OpenAlex
W2011083127
Cited by
322
References
41
Citations by year
2026: 23 · 2025: 15 · 2024: 22 · 2023: 18 · 2022: 21 · 2021: 18 · 2020: 20 · 2019: 22 · 2018: 25 · 2017: 21 · 2016: 24 · 2015: 20 · 2014: 6 · 2013: 11 · 2012: 12
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Addiction (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (Z99 DA999999)
  • National Institute on Drug Abuse (Z01DA000001)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
self-administration, behavioral reinforcement, animal models of addiction, neurobiology of addiction, drug use behavior
MeSH terms
Animals, Haplorhini, Humans, Reinforcement, Psychology, Self Administration, Behavior, Addictive, Substance-Related Disorders, Models, Animal, Rats

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