The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Deep brain stimulation for chronic pain investigated with magnetoencephalography
Open accessAbstract
Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.
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“when the stimulator was turned off, worsening symptoms were associated with reduced activity in the same areas”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [59]
In the citing paper
“During stimulation, subjective symptom relief was correlated with significantly increased activity in the left midanterior orbitofrontal cortex and right subgenual cingulate cortex”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [59]
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Cites
Deep Brain Stimulation for Treatment-Resistant Depression
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Subgenual prefrontal cortex abnormalities in mood disorders
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The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180
Self-citationPlacebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
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Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824
Self-citationSignal Processing in Magnetoencephalography
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Deep brain stimulation for pain relief: A meta-analysis
Bittar, R. G., Kar-Purkayastha, I., Owen, S. L. F., Bear, R. E., Green, A. L., Wang, S., & Aziz, T. Z. (2005) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2004.10.005 · Cited by 397
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Johnson, T. D., Mohan, B., Huang, H., Cramer, J., Drees, C. N., Hoerth, M. T., Crepeau, A. Z., Drazkowski, J., Noe, K. H., Baxter, L., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117659
Metadata
- Authors
- Kringelbach, M. L., Jenkinson, N., Green, A. L., Owen, S. L. F., Hansen, P. C., Cornelissen, P. L., Holliday, I. E., Stein, J., & Aziz, T. Z.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Newcastle University (GB)
- Aston University (GB)
- Corresponding author
- Kringelbach, Morten L.
- Aziz, Tipu Z.
- ORCID
- Venue
- NeuroReport
- Published
- 2007-02-12
- Volume
- 18
- Issue
- 3
- Pages
- 223-228
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1964099314
- Cited by
- 101
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 10 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, chronic pain, phantom limb pain, magnetoencephalography, orbitofrontal cortex, subgenual anterior cingulate cortex, treatment-resistant pain, surgical targets
- MeSH terms
- Brain, Brain Mapping, Chronic Disease, Gyrus Cinguli, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Pain, Intractable, Intractable Pain, Phantom Limb, Predictive Value of Tests, Magnetoencephalography, Treatment Outcome, Prefrontal Cortex, Deep Brain Stimulation
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