The human orbitofrontal cortex: linking reward to hedonic experience

Kringelbach, Morten L.

doi:10.1038/nrn1747

Cited by 2,180Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorOlfactory and Sensory Function Studies

The human orbitofrontal cortex: linking reward to hedonic experience

Kringelbach, Morten L.·2005·Nature Reviews Neuroscience

DOI 10.1038/nrn1747

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Abstract

Hedonic experience is arguably at the heart of what makes us human. In recent neuroimaging studies of the cortical networks that mediate hedonic experience in the human brain, the orbitofrontal cortex has emerged as the strongest candidate for linking food and other types of reward to hedonic experience. The orbitofrontal cortex is among the least understood regions of the human brain, but has been proposed to be involved in sensory integration, in representing the affective value of reinforcers, and in decision making and expectation. Here, the functional neuroanatomy of the human orbitofrontal cortex is described and a new integrated model of its functions proposed, including a possible role in the mediation of hedonic experience.

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The conscious subjective experience of pleasure and reward likely takes place in the orbitofrontal cortex, which has reciprocal links with the mesolimbic system.
“The conscious subjective experience of pleasure and reward likely takes place in the orbitofrontal cortex, which has reciprocal links with the mesolimbic system 85, 86.”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [86]
The approach module comprises subcortical and cortical structures that are major sites of dopamine action, primarily striatum and medial/orbital prefrontal cortices.
“This neural system comprises subcortical and cortical structures that are major sites of dopamine action, and include primarily the striatum (caudate nucleus, putamen and nucleus accumbens) (e.g., Di Chiara, 2002; Di Chiara and Bassareo, 2007; McClure et al., 2004; Schultz et al., 1998; Wise, 2004) and the medial and orbital prefrontal cortices (Jensen et al., 2003; Kringelbach, 2005).”
From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Kringelbach, 2005
This pattern is consistent with previous studies related to right lOFC function.
“However, this pattern is consistent with previous studies related to right lOFC function 39 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [39]

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Authors: Kringelbach, M. L.
Affiliations: University of Oxford (GB)
Corresponding author: Kringelbach, Morten L.
ORCID: Kringelbach, Morten L.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-09
Volume: 6
Issue: 9
Pages: 691-702
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1747
OpenAlex: W2006819294
Cited by: 2,180
References: 123
Citations by year: 2026: 67 · 2025: 82 · 2024: 78 · 2023: 99 · 2022: 118 · 2021: 101 · 2020: 137 · 2019: 111 · 2018: 107 · 2017: 121 · 2016: 120 · 2015: 119 · 2014: 145 · 2013: 141 · 2012: 126
FWCI: 5.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords: orbitofrontal cortex, hedonic experience, reward, food reward, sensory integration, decision-making, expectations, functional neuroanatomy
MeSH terms: Brain Mapping, Frontal Lobe, Humans, Magnetic Resonance Imaging, Philosophy, Reward

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The human orbitofrontal cortex: linking reward to hedonic experience

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