Treatment of Dual Diagnosis Disorders
Abstract
PURPOSE OF REVIEW: Treatment of dual diagnosis [co-occurrence of a substance use disorder (SUD) in patients with mental illness] poses several challenges for mental health professionals. This article seeks to review the recent advances in dual diagnosis treatment with respect to pharmacotherapy and psychosocial approaches. RECENT FINDINGS: Atypical antipsychotics are commonly used for comorbid schizophrenia and SUD. Whereas there is no difference between risperidone and olanzapine, clozapine appears to have a distinct advantage in reducing psychotic symptoms as well as substance abuse (including smoking). There is emerging evidence that quetiapine is beneficial in dually diagnosed patients, particularly using alcohol, cocaine and amphetamine. A combination of naltrexone and sertraline was found to be effective in patients with depressive disorder and alcohol dependence. Effectiveness of atomoxetine is yet to be established in patients with comorbid adult attention-deficit/hyperactivity disorder with respect to decrease in substance abuse. Integrated intervention is the choice of treatment for patients with dual diagnosis. SUMMARY: In spite of the high association between substance use and psychiatric disorders, there is a surprising paucity of studies related to treatment and outcome. A few well-designed studies have been recently published and more studies of this nature are required in order to address the challenges posed in the treatment of dual disorders.
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Integrated care models, which combine SUD and mental health treatment, have demonstrated efficacy in improving outcomes for individuals with comorbid SUDs and psychiatric disorders.
“Integrated care models, which combine SUD and mental health treatment, have demonstrated efficacy in improving outcomes for this complex population [18].”
From Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review (2024) · cites this paper as [18]
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- Authors
- Murthy, P., & Chand, P.
- Affiliations
- National Institute of Mental Health and Neurosciences (IN)
- Corresponding author
- Murthy, Pratima
- Venue
- Current Opinion in Psychiatry
- Published
- 2012-05
- Volume
- 25
- Issue
- 3
- Pages
- 194-200
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2067425226
- Cited by
- 115
- References
- 42
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 15 · 2013: 10
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- dual diagnosis, substance use disorders, psychiatric comorbidity, pharmacotherapy, psychosocial interventions, atypical antipsychotics, clozapine, risperidone, olanzapine, quetiapine, naltrexone, sertraline, atomoxetine, integrated intervention, alcoholism, smoking, cocaine, amphetamine, attention deficit hyperactivity disorder
- MeSH terms
- Mental Disorders, Drug Therapy, Combination, Humans, Narcotic Antagonists, Psychotherapy, Antipsychotic Agents, Comorbidity, Diagnosis, Dual (Psychiatry), Substance-Related Disorders
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