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Cited by 464Chronic Disease Management StrategiesMental Health Treatment and AccessMusculoskeletal pain and rehabilitation

The Impact of Comorbidity of Mental and Physical Conditions on Role Disability in the US Adult Household Population

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Merikangas, Kathleen R., Ames, Minnie, Cui, Lihong, Stang, Paul E., Ustun, T. Bedirhan, Von Korff, Michael, Kessler, Ronald C.·2007·Archives of General Psychiatry
DOI 10.1001/archpsyc.64.10.1180PMC PMC2248275
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Abstract

CONTEXT: There is limited information that accounts for comorbidity on the impact of role disability associated with a wide range of mental and physical disorders in population-based samples. OBJECTIVE: To estimate the comparative effects of common mental and physical conditions on role disability in the general population using a novel method that accounts for comorbidity. DESIGN: Direct interviews about physical and mental conditions during the past year. SETTING: The National Comorbidity Survey Replication, a nationally representative series of face-to-face interviews. PATIENTS: A nationally representative sample of adults living in households (N = 5962 respondents, 18 years and older). MAIN OUTCOME MEASURE: Disability in major life roles was assessed with the World Health Organization Disability Assessment Schedule. Simulations that allow for complex interactions among conditions were used to estimate the conditions' effects on disability days, when respondents were completely unable to carry out their usual daily activities because of problems with mental or physical health, in the past 12 months. RESULTS: An estimated 53.4% of US adults have 1 or more of the mental or physical conditions assessed in the survey. These respondents report an average 32.1 more role-disability days in the past year than demographically matched controls, equivalent to nearly 3.6 billion days of role disability in the population. Musculoskeletal disorders and major depression had the greatest effects on disability days. Mental conditions accounted for more than half as many disability days as all physical conditions at the population level. Associations of specific conditions with disability decreased substantially after controlling for comorbidity, suggesting that prior studies, which generally did not control for comorbidity, overestimated disease-specific effects. CONCLUSION: The staggering amount of health-related disability associated with mental and physical conditions should be considered in establishing priorities for the allocation of health care and research resources.

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  1. Spitzer, RL.; Gibbon, M.; Williams, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patient Edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute; 2002.
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Authors
Merikangas, K. R., Ames, M., Cui, L., Stang, P. E., Ustun, T. B., Von Korff, M., & Kessler, R. C.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2007-10-01
Volume
64
Issue
10
Pages
1180
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.64.10.1180
PMC
PMC2248275
OpenAlex
W2166733613
Cited by
464
References
58
Citations by year
2026: 5 · 2025: 6 · 2024: 10 · 2023: 10 · 2022: 16 · 2021: 21 · 2020: 19 · 2019: 15 · 2018: 32 · 2017: 55 · 2016: 26 · 2015: 31 · 2014: 37 · 2013: 22 · 2012: 34
FWCI
22.47
Type
journal article
Language
en
Open access
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
  • John W. Alden Trust (R01-MH069864, R13-MH066849)
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • Pfizer
  • AstraZeneca
  • GlaxoSmithKline
  • Sanofi
  • National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05, R01-MH069864, R13-MH066849)
  • Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849)
  • Pan American Health Organization
  • National Institute of Mental Health (R13-MH-066849, R01‐MH070884, U01-MH-60220, MH60220, MH070884, MH069864, U13MH066849, MH066849, U01MH060220, R01‐MH069864)
  • National Institute on Drug Abuse (K05DA015799, R01DA016558, U01-MH60220)
  • Fogarty International Center (FIRCA R01-TW006481, R01-TW006481, R03TW006481)
Topics
  • Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
comorbidities, mental illness, physical disorders, disability days, musculoskeletal disorders, major depressive disorder, National Comorbidity Survey Replication, healthcare resource allocation
MeSH terms
Activities of Daily Living, Adolescent, Adult, Age Factors, Mental Disorders, Data Collection, Major Depressive Disorder, Disability Evaluation, Persons with Disabilities, Health Priorities, Health Surveys, Humans, Musculoskeletal Diseases, Role, United States, Comorbidity, Prevalence, Cost of Illness, Health Care Reform

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