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Possible association between the prolactin receptor gene and callous-unemotional traits among aggressive children
Abstract
This study examined the possible association between prolactin (PRL) system genes and callous-unemotional (CU) traits in childhood-onset aggression. Two markers for the PRL peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped. The participants were assessed on the CU subscale using five items from the Antisocial Process Screening Device. Genotype analysis showed nominally significant results with PRLR_rs187490 (uncorrected P=0.01), with the GG genotype associated with higher CU scores. This is the first paper to evaluate the relationship of PRL system genes with CU traits in childhood-onset aggression.
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“NS for PRL, PRLR SNPs, or two-marker haplotypes”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Hirata [165]
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Genetics of child aggression, a systematic review
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Metadata
- Authors
- Hirata, Y., Zai, C. C., Nowrouzi, B., Shaikh, S. A., Kennedy, J. L., & Beitchman, J. H.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Kennedy, James L.
- Venue
- Psychiatric Genetics
- Published
- 2016-02
- Volume
- 26
- Issue
- 1
- Pages
- 48-51
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2339074466
- Cited by
- 5
- References
- 35
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 2 · 2017: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Foundation for Suicide Prevention
- Centre for Addiction and Mental Health
- Centre for Addiction and Mental Health Foundation
- Eli Lilly Canada
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- prolactin receptor gene, callous-unemotional traits, antisocial behavior, genetic association, Antisocial Process Screening Device
- MeSH terms
- Adolescent, Aggression, Antisocial Personality Disorder, Child, Emotions, Female, Humans, Male, Receptors, Prolactin, Polymorphism, Single Nucleotide, Genetic Association Studies
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