The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents
Abstract
OBJECTIVE: Gene-environment interactions that moderate aggressive behavior have been identified in association with the MAOA (monoamine oxidase A) gene. The present study examined the moderating effect of MAOA-VNTR (variable number of tandem repeats) on aggression behavior relating to child abuse among Chinese adolescents. MATERIALS AND METHODS: A sample of 507 healthy Chinese male adolescents completed the Child Trauma Questionnaire-Short Form (CTQ-SF) and Youth Self-report of the Child Behavior Checklist. The participants' buccal cells were sampled and subjected to DNA analysis. The effects of childhood abuse (CTQ-SF scores), MAOA-VNTR [high-activity allele (H) versus low-activity allele (L)], and their interaction in aggressive behaviors were analyzed by linear regression. RESULTS: Child maltreatment was found to be a significant independent factor in the manifestation of aggressive behavior, whereas MAOA activity was not. There was a significant interaction between MAOA-VNTR and childhood maltreatment in the exhibition of aggressive behaviors. In the context of physical or emotional abuse, boys in the MAOA-L group showed a greater tendency toward aggression than those in the MAOA-H group. CONCLUSION: Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood maltreatment experienced, among Chinese adolescents.
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“significant interaction MAOA x total abuse (β = −0.258, t = −2.687, P = 0.008): Among those with childhood maltreatment, L (3 or 5 repeats) group associated with higher aggression scores vs H (3.5 or 4 repeats) group”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
In the citing paper
“NS main effect of MAOA VNTR”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
In the citing paper
“also MAOA x physical abuse (β = −0.273, t = −2.114, P = 0.035) and MAOA x emotional abuse (β = −0.255, t = −2.240, P = 0.026)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
Citations
Cites
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079
Duncan, L. E., & Keller, M. C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020191 · Cited by 1,032
Child abuse and neglect and the brain–a review
Glaser, D. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963099004990 · Cited by 827
DE BELLIS, M. D. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003078 · Cited by 816
Physical Maltreatment Victim to Antisocial Child: Evidence of an Environmentally Mediated Process.
Jaffee, S. R., Caspi, A., Moffitt, T. E., & Taylor, A. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.44 · Cited by 454
Research works printed but not linked: 1
- Li, 2005, The investigation of urban child abuse and influencing factors in Xinyu, Chin J Gen Pract, 4, 502
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Kolla, N. J., & Bortolato, M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101875 · Cited by 138
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33
Metadata
- Authors
- Zhang, Y., Ming, Q., Wang, X., & Yao, S.
- Affiliations
- Central South University (CN)
- Corresponding author
- Yao, Shuqiao
- Venue
- Psychiatric Genetics
- Published
- 2016-06
- Volume
- 26
- Issue
- 3
- Pages
- 117-123
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2294535673
- Cited by
- 28
- References
- 60
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Technologies Research and Development Program
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- monoamine oxidase A, childhood abuse, child abuse, aggression, gene-environment interaction, moderating effect, physical abuse, emotional abuse, Chinese adolescents, adolescent boys
- MeSH terms
- Adolescent, Adolescent Behavior, Aggression, Child Abuse, China, Genotype, Humans, Male, Monoamine Oxidase, Cohort Studies, Case-Control Studies, Minisatellite Repeats
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- Zhang, Y., Ming, Q., Wang, X., & Yao, S. (2016). The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents. Psychiatric Genetics. https://doi.org/10.1097/ypg.0000000000000125
