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The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents
Abstract
OBJECTIVE: Gene-environment interactions that moderate aggressive behavior have been identified in association with the MAOA (monoamine oxidase A) gene. The present study examined the moderating effect of MAOA-VNTR (variable number of tandem repeats) on aggression behavior relating to child abuse among Chinese adolescents. MATERIALS AND METHODS: A sample of 507 healthy Chinese male adolescents completed the Child Trauma Questionnaire-Short Form (CTQ-SF) and Youth Self-report of the Child Behavior Checklist. The participants' buccal cells were sampled and subjected to DNA analysis. The effects of childhood abuse (CTQ-SF scores), MAOA-VNTR [high-activity allele (H) versus low-activity allele (L)], and their interaction in aggressive behaviors were analyzed by linear regression. RESULTS: Child maltreatment was found to be a significant independent factor in the manifestation of aggressive behavior, whereas MAOA activity was not. There was a significant interaction between MAOA-VNTR and childhood maltreatment in the exhibition of aggressive behaviors. In the context of physical or emotional abuse, boys in the MAOA-L group showed a greater tendency toward aggression than those in the MAOA-H group. CONCLUSION: Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood maltreatment experienced, among Chinese adolescents.
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“significant interaction MAOA x total abuse (β = −0.258, t = −2.687, P = 0.008): Among those with childhood maltreatment, L (3 or 5 repeats) group associated with higher aggression scores vs H (3.5 or 4 repeats) group”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
In the citing paper
“NS main effect of MAOA VNTR”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
In the citing paper
“also MAOA x physical abuse (β = −0.273, t = −2.114, P = 0.035) and MAOA x emotional abuse (β = −0.255, t = −2.240, P = 0.026)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [50]
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Metadata
- Authors
- Zhang, Y., Ming, Q., Wang, X., & Yao, S.
- Affiliations
- Central South University (CN)
- Corresponding author
- Yao, Shuqiao
- Venue
- Psychiatric Genetics
- Published
- 2016-06
- Volume
- 26
- Issue
- 3
- Pages
- 117-123
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2294535673
- Cited by
- 28
- References
- 60
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Technologies Research and Development Program
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- monoamine oxidase A, childhood abuse, child abuse, aggression, gene-environment interaction, moderating effect, physical abuse, emotional abuse, Chinese adolescents, adolescent boys
- MeSH terms
- Adolescent, Adolescent Behavior, Aggression, Child Abuse, China, Genotype, Humans, Male, Monoamine Oxidase, Cohort Studies, Case-Control Studies, Minisatellite Repeats
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