The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder
Open accessAbstract
Stress increases the risk for major depressive disorder (MDD), overeating, and alcohol dependence (AD). The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the neuropeptide Y receptor Y2 (NPY2R). The functional NPY2R variant rs6857715 (C-599T) has been implicated in both obesity and AD, but with opposing alleles. The present study explored whether rs6857715 is also associated with MDD. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C [P=0.020, odds ratio (OR) (C-allele)=1.18]. The association remained significant after excluding MDD patients with AD/alcohol abuse [P=0.038, OR (C-allele)=1.18]; increased weight/appetite [P=0.006, OR (C-allele)=1.23]; or both [P=0.008, OR (C-allele)=1.25]. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD.
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“This review highlighted the myriad ways of measuring depression and its determinants [66,85,281,298,451,485].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [85]
Citations
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Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
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N6-methyladenosine and Neurological Diseases
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A Systematic Review of Candidate Genes for Major Depression
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Wang, W., Xu, T., Chen, X., Dong, K., Du, C., Sun, J., Shi, C., Li, X., Yang, Y., Li, H., et al. (2019) · Mediators of Inflammation · doi:10.1155/2019/7898095 · Cited by 24
Metadata
- Authors
- Treutlein, J., Strohmaier, J., Frank, J., Witt, S. H., Rietschel, L., Forstner, A. J., Lang, M., Degenhardt, F., Dukal, H., Herms, S., Streit, F., Hoffmann, P., Cichon, S., Nöthen, M. M., & Rietschel, M.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Rietschel, Liz
- Rietschel, Marcella
- ORCID
- Venue
- Psychiatric Genetics
- Published
- 2017-02
- Volume
- 27
- Issue
- 1
- Pages
- 34-37
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2517258138
- Cited by
- 18
- References
- 27
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Psychiatric Genetics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
- Open Access CRIS of the University of Bern
- Funders
- Deutsche Forschungsgemeinschaft (NO246/10-1, SFB 636, FOR 2107, RI 908/11-1)
- Universität Heidelberg
- Bundesministerium für Bildung und Forschung (01ZX1311A, 01ZX1314G, 01GS08147, 01GS08144, 01ZX1314A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- major depressive disorder, NPY2R, promoter polymorphism, genetic association, alcoholism, alcohol abuse, stress response, appetite, weight gain, obesity
- MeSH terms
- Adult, Alcoholism, Alleles, Major Depressive Disorder, Female, Germany, Humans, Male, Middle Aged, Neuropeptide Y, Obesity, Promoter Regions, Genetic, Odds Ratio, Case-Control Studies, Receptors, Neuropeptide Y, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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