The olfactory receptor gene repertoires in secondary-adapted marine vertebrates: evidence for reduction of the functional proportions in cetaceans
Open accessAbstract
An olfactory receptor (OR) multigene family is responsible for the well-developed sense of smell possessed by terrestrial tetrapods. Mammalian OR genes had diverged greatly in the terrestrial environment after the fish–tetrapod split, indicating their importance to land habitation. In this study, we analysed OR genes of marine tetrapods (minke whale Balaenoptera acutorostrata, dwarf sperm whale Kogia sima, Dall's porpoise Phocoenoides dalli, Steller's sea lion Eumetopias jubatus and loggerhead sea turtle Caretta caretta) and revealed that the pseudogene proportions of OR gene repertoires in whales were significantly higher than those in their terrestrial relative cattle and also in sea lion and sea turtle. On the other hand, the pseudogene proportion of OR sequences in sea lion was not significantly higher compared with that in their terrestrial relative (dog). It indicates that secondary perfectly adapted marine vertebrates (cetaceans) have lost large amount of their OR genes, whereas secondary-semi-adapted marine vertebrates (sea lions and sea turtles) still have maintained their OR genes, reflecting the importance of terrestrial environment for these animals.
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Phenotypic convergence is generally believed to be a strong signature of natural selection.
“Phenotypic convergence, in which the same function or morphology evolves multiple times independently, often due to adaption to similar environmental changes, is generally believed to be a strong signature of natural selection”
From Bayesian Detection of Convergent Rate Changes of Conserved Noncoding Elements on Phylogenetic Trees (2019) · cites this paper as Kishida et al. 2007
The paper’s introduction (p. 428) and results discuss olfactory-receptor gene loss in marine vertebrates. Searches for phenotypic convergence and natural selection found no passage in our copy stating that convergence is generally considered a strong signature of natural selection. (LLM, conf=0.72)
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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Buck, L., & Axel, R. (1991) · Cell · doi:10.1016/0092-8674(91)90418-x · Cited by 4,987 · see citing works
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Human olfaction: from genomic variation to phenotypic diversity
Hasin-Brumshtein, Y., Lancet, D., & Olender, T. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.02.002 · Cited by 176 · see citing works
Bayesian Detection of Convergent Rate Changes of Conserved Noncoding Elements on Phylogenetic Trees
Hu, Z., Sackton, T. B., Edwards, S. V., & Liu, J. S. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz049 · Cited by 69 · see citing works
- Authors
- Kishida, T., Kubota, S., Shirayama, Y., & Fukami, H.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Kishida, Takushi
- Venue
- Biology Letters
- Publisher
- The Royal Society
- Published
- 2007-05-29
- Volume
- 3
- Issue
- 4
- Pages
- 428-430
- ISSN
- 1744-9561 (ISSN-L)
- 1744-957X
- PMC
- PMC2390674
- OpenAlex
- W2114555726
- Cited by
- 141
- References
- 1
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 12 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 18 · 2012: 7
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biology Letters (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Physical Sciences › Environmental Science › Ecology › Marine animal studies overview
- Health Sciences › Medicine › Urology › Comparative Animal Anatomy Studies
- Keywords
- olfactory receptor genes, cetaceans, marine adaptation, secondary adaptation, Balaenoptera acutorostrata, dwarf sperm whale, Dall's porpoise, Caretta caretta, gene loss, olfaction, marine mammals, sea lions, sea turtles
- MeSH terms
- Animals, Base Sequence, Cattle, Dogs, Female, Male, Molecular Sequence Data, Mutation, Phylogeny, Pseudogenes, Turtles, Whales, Sequence Analysis, DNA, Receptors, Odorant, Evolution, Molecular, Porpoises, Sea Lions
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