The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Antibiotic-decorated titanium with enhanced antibacterial activity through adhesive polydopamine for dental/bone implant
Open accessAbstract
Implant-associated infections, which are normally induced by microbial adhesion and subsequent biofilm formation, are a major cause of morbidity and mortality. Therefore, practical approaches to prevent implant-associated infections are in great demand. Inspired by adhesive proteins in mussels, here we have developed a novel antibiotic-decorated titanium (Ti) material with enhanced antibacterial activity. In this study, Ti substrate was coated by one-step pH-induced polymerization of dopamine followed by immobilization of the antibiotic cefotaxime sodium (CS) onto the polydopamine-coated Ti through catechol chemistry. Contact angle measurement and X-ray photoelectron spectroscopy confirmed the presence of CS grafted on the Ti surface. Our results demonstrated that the antibiotic-grafted Ti substrate showed good biocompatibility and well-behaved haemocompatibility. In addition, the antibiotic-grafted Ti could effectively prevent adhesion and proliferation of Escherichia coli (Gram-negative) and Streptococcus mutans (Gram-positive). Moreover, the inhibition of biofilm formation on the antibiotic-decorated Ti indicated that the grafted CS could maintain its long-term antibacterial activity. This modified Ti substrate with enhanced antibacterial activity holds great potential as implant material for applications in dental and bone graft substitutes.
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“The resulting PDA–AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [66]
In the citing paper
“Importantly, the presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.31,66,67”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [66]
Citations
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Banerjee, I., Pangule, R. C., & Kane, R. S. (2010) · Advanced Materials · doi:10.1002/adma.201001215 · Cited by 2,795
Watnick, P. I., & Kolter, R. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.10.2675-2679.2000 · Cited by 1,434
The significance of infection related to orthopedic devices and issues of antibiotic resistance
Campoccia, D., Montanaro, L., & Arciola, C. R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.044 · Cited by 1,113
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
Polydopamine—a nature-inspired polymer coating for biomedical science
Lynge, M. E., van der Westen, R., Postma, A., & Städler, B. (2011) · Nanoscale · doi:10.1039/c1nr10969c · Cited by 907
Jacobsen, S. M., Stickler, D. J., Mobley, H. L. T., & Shirtliff, M. E. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00019-07 · Cited by 853
Advances in polymers for anti-biofouling surfaces
Krishnan, S., Weinman, C. J., & Ober, C. K. (2008) · Journal of Materials Chemistry · doi:10.1039/b801491d · Cited by 825
Jiang, J., Zhu, L., Zhu, L., Zhu, B., & Xu, Y. (2011) · Langmuir · doi:10.1021/la202877k · Cited by 750
General functionalization route for cell adhesion on non-wetting surfaces
Ku, S. H., Ryu, J., Hong, S. K., Lee, H., & Park, C. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.020 · Cited by 687
Gottenbos, B., van der Mei, H. C., Klatter, F. A., Nieuwenhuis, P., & Busscher, H. J. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00263-0 · Cited by 505
Peri-implant Inflammation Defined by the Implant-Abutment Interface
Broggini, N., McManus, L. M., Hermann, J. S., Medina, R., Schenk, R., Buser, D., & Cochran, D. L. (2006) · Journal of Dental Research · doi:10.1177/154405910608500515 · Cited by 481
Systematic review of survival rates for implants placed in the grafted maxillary sinus
FABBRO, M. D., Testori, T., Francetti, L. A., & Weinstein, R. (2005) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2005.04.024 · Cited by 470
Chen, C. Z., Beck-Tan, N. C., Dhurjati, P., van Dyk, T. K., LaRossa, R. A., & Cooper, S. L. (2000) · Biomacromolecules · doi:10.1021/bm0055495 · Cited by 443
Sileika, T. S., Kim, H., Maniak, P., & Messersmith, P. B. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am200978h · Cited by 377
Kazemzadeh‐Narbat, M., Lai, B., Ding, C., Kizhakkedathu, J. N., Hancock, R. E. W., & Wang, R. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.036 · Cited by 361
Yang, K., Lee, J. S., Kim, J., Lee, Y. B., Shin, H., Um, S. H., Kim, J. B., Park, K. I., Lee, H., & Cho, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.067 · Cited by 346
Ding, X., Yang, C. H., Lim, T.-P., Hsu, L. Y., Engler, A. C., Hedrick, J. L., & Yang, Y. Y. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.001 · Cited by 339
Immobilized antibiotics to prevent orthopedic implant infections
Hickok, N., & Shapiro, I. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.015 · Cited by 289
Albers, C. E., Hofstetter, W., Siebenrock, K. A., Landmann, R. M., & Klenke, F. M. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.626538 · Cited by 261
The Peri‐Implantitis: Implant Surfaces, Microstructure, and Physicochemical Aspects
Mouhyi, J., Ehrenfest, D. M. D., & Albrektsson, T. O. (2009) · Clinical Implant Dentistry and Related Research · doi:10.1111/j.1708-8208.2009.00244.x · Cited by 239
The effect of VEGF functionalization of titanium on endothelial cells in vitro
Poh, C. K., Shi, Z., Lim, T. Y., Neoh, K. G., & Wang, W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.042 · Cited by 236
Shukla, S. K., & Quraishi, M. A. (2009) · Corrosion Science · doi:10.1016/j.corsci.2009.02.024 · Cited by 234
Vasiliu, S., Bunia, I., Racoviță, Ș., & Neagu, V. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.02.039 · Cited by 210
Rim, N. G., Kim, S. J., Shin, Y. M., Jun, I., Lim, D. W., Park, J. H., & Shin, H. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.10.057 · Cited by 201
DeJong, J. T., Soga, K., Banwart, S. A., Whalley, W. R., Ginn, T. R., Nelson, D. C., Montoya, B. M., Martinez, B. C., & Barkouki, T. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0270 · Cited by 201
Surface modification of PVDF porous membranes via poly(DOPA) coating and heparin immobilization
Zhu, L.-P., Yu, J.-Z., Xu, Y., Xi, Z., & Zhu, B. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.11.011 · Cited by 197
Luo, R., Tang, L., Wang, J., Zhao, Y., Tu, Q., Weng, Y., Shen, R., & Huang, N. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.01.033 · Cited by 185
Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)
Aslan, S., Loebick, C. Z., Kang, S., Elimelech, M., Pfefferle, L. D., & Tassel, P. R. V. (2010) · Nanoscale · doi:10.1039/c0nr00329h · Cited by 152
Wang, R., Neoh, K. G., Shi, Z., Kang, E. T., Tambyah, P. A., & Chiong, E. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23342 · Cited by 152
Systematic review of survival rates for implants placed in the grafted maxillary sinus.
FABBRO, M. D., Testori, T., Francetti, L. A., & Weinstein, R. (2004) · PubMed · Cited by 127
Wagner, V., Koberstein, J. T., & Bryers, J. D. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.020 · Cited by 124
Wei, Q., Li, B., Yi, N., Su, B., Yin, Z., Zhang, F., Li, J., & Zhao, C. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32956 · Cited by 113
Bactericidal strontium-releasing injectable bone cements based on bioactive glasses
Brauer, D. S., Karpukhina, N. G., Kedia, G., Bhat, A. R., Law, R. V., Radecka, I., & Hill, R. G. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0647 · Cited by 107
Desai, D. G., Liao, K. S., Cevallos, M. E., & Trautner, B. W. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.07.036 · Cited by 105
Maggot Excretions Inhibit Biofilm Formation on Biomaterials
Cazander, G., van de Veerdonk, M. C., Vandenbroucke‐Grauls, C. M. J. E., Schreurs, M. W. J., & Jukema, G. N. (2010) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-010-1309-5 · Cited by 98
Sun, Y., Deng, Y., Ye, Z., Liang, S., Tang, Z., & Wei, S. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.05.037 · Cited by 95
Self-citationAntibacterial burst-release from minimal Ag-containing plasma polymer coatings
Guimond-Lischer, S., Körner, E., Balazs, D. J., Shen, D., Wick, P., Grieder, K., Haas, D., Heuberger, M. P., & Hegemann, D. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0596 · Cited by 90
Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemical deposition
Lu, X., Zhang, B., Wang, Y., Zhou, X., Weng, J., Qu, S., Feng, B., Watari, F., Ding, Y., & Leng, Y. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0366 · Cited by 90
Saidin, S., Chevallier, P., Kadir, M. R. A., Hermawan, H., & Mantovani, D. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.07.026 · Cited by 89
Shin, Y. M., Lee, Y. B., & Shin, H. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.05.004 · Cited by 89
Mussel-Inspired Anchoring for Patterning Cells Using Polydopamine
Sun, K., Xie, Y., Ye, D., Zhao, Y., Cui, Y., Long, F., Zhang, W., & Jiang, X. (2012) · Langmuir · doi:10.1021/la2041967 · Cited by 87
Safety of parenteral third-generation cephalosporins
Fekety, F. R. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90326-9 · Cited by 72
Observations on the adherence of Proteus mirabilis onto polymer surfaces
Stickler, D. J., Lear, J. C., Morris, N., Macleod, S. M., Downer, A., Cadd, D. H., & Feast, W. J. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02840.x · Cited by 71
RAAD, I. I., Reitzel, R. A., Jiang, Y., Chemaly, R. F., Dvorak, T. L., & Hachem, R. Y. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn281 · Cited by 70
Ren, N., Li, R., Chen, L., Wang, G., Liu, D., Wang, Y., Zheng, L., Tang, W., Yu, X., Jiang, H., et al. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm32434b · Cited by 66
Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans
Hunt, P. R., Marquis, B. J., Tyner, K. M., Conklin, S. D., Olejnik, N., Nelson, B. C., & Sprando, R. L. (2013) · Journal of Applied Toxicology · doi:10.1002/jat.2872 · Cited by 65
Sharma, R., Choudhary, S., & Kishore, N. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.03.007 · Cited by 56
Deng, Y., Zhang, X., Zhao, X., Li, Q. T., Ye, Z., Li, Z., Liu, Y., Zhou, Y., Ma, H., Pan, G., et al. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.07.017 · Cited by 54
Self-citationNie, F. L., Zheng, Y., Wei, S., Wang, D. S., Yu, Z., Salimgareeva, G., Polyakov, A. V., & Valiev, R. Z. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34472 · Cited by 48
Self-citationThe effect of adhesive ligands on bacterial and fibroblast adhesions to surfaces
He, T., Shi, Z., Fang, N., Neoh, K. G., Kang, E. T., & Chan, V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.049 · Cited by 48
A new method for evaluating the most-stable contact angle using mechanical vibration
Rodríguez-Valverde, M. A., Ruiz‐Cabello, F. J. M., & Cabrerizo-Vílchez, M. Á. (2010) · Soft Matter · doi:10.1039/c0sm00939c · Cited by 37
Therapy in two cases of neonatal foal septicaemia and meningitis with cefotaxime sodium
Morris, D. D., RUTKOWSKI, J., & Lloyd, K. C. K. (1987) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1987.tb02614.x · Cited by 34
An X-ray and neutron reflectometry study of ‘PEG-like’ plasma polymer films
Menzies, D. J., Nelson, A. R. J., Shen, H., McLean, K. M., Forsythe, J. S., Gengenbach, T. R., Fong, C., & Muir, B. W. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0509 · Cited by 27
Dzhekieva, L., Kumar, I., & Pratt, R. F. (2012) · Biochemistry · doi:10.1021/bi300148v · Cited by 26
Tan, X. W., Lakshminarayanan, R., Liu, S. P., Goh, E. T. L., Tan, D. T.-H., Beuerman, R. W., & Mehta, J. S. (2012) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.32774 · Cited by 22
Safety of cefotaxime and other new -lactam antibiotics
Parker, R. H., & Park, S.-Y. (1984) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/14.suppl_b.331 · Cited by 20
Quality of cefotaxime sodium preparations.
Wetterich, U., & Mutschler, E. (1995) · PubMed · Cited by 11
My, N. H., Hirao, H., Van, D. U., & Morokuma, K. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci2004175 · Cited by 10
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Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality
Han, L., Yan, L., Wang, K., Fang, L., Zhang, H., Tang, Y., Ding, Y., Weng, L., Xu, J., Weng, J., et al. (2017) · NPG Asia Materials · doi:10.1038/am.2017.33 · Cited by 599
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Zhang, E., Zhao, X., Hu, J., Wang, R., Fu, S., & Qin, G. W. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.030 · Cited by 562
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Fu, Y., Yang, L., Zhang, J., Hu, J., Duan, G., Liu, X., Li, Y., & Gu, Z. (2021) · Materials Horizons · doi:10.1039/d0mh01985b · Cited by 546
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Batul, R., Tamanna, T., Khaliq, A., & Yu, A. (2017) · Biomaterials Science · doi:10.1039/c7bm00187h · Cited by 300
Metadata
- Authors
- He, S., Zhou, P., Wang, L., Xiong, X., Zhang, Y., Deng, Y., & Wei, S.
- Affiliations
- Peking University (CN)
- Capital Medical University (CN)
- Corresponding author
- Deng, Yi
- Wei, Shicheng
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2014-06-06
- Volume
- 11
- Issue
- 95
- Pages
- 20140169
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- PMC
- PMC4006258
- OpenAlex
- W2137999805
- Cited by
- 142
- References
- 59
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 14 · 2015: 4 · 2014: 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of The Royal Society Interface (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- polydopamine coating, cefotaxime sodium, antibacterial activity, implant-associated infection, biofilm inhibition, bacterial adhesion, catechol chemistry, dental implants, bone implants, hemocompatibility, biocompatibility, Escherichia coli, Streptococcus mutans
- MeSH terms
- Anti-Bacterial Agents, Bacterial Adhesion, Cefotaxime, Escherichia coli, Humans, Materials Testing, Streptococcus mutans, Titanium, Dental Implants, Biofilms, Coated Materials, Biocompatible
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