The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Oxidants, antioxidants and the current incurability of metastatic cancers
Open accessAbstract
The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antioxidants that effectively block otherwise highly effective oxidant therapies. Also key to better understanding is why and how the anti-diabetic drug metformin (the world's most prescribed pharmaceutical product) preferentially kills oxidant-deficient mesenchymal p53 − − cells. A much faster timetable should be adopted towards developing more new drugs effective against p53 − − cancers.
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Cites
1 retracted
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RetractedTargeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
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Cited by
Cellular mechanisms and physiological consequences of redox-dependent signalling
Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093
Antioxidants Accelerate Lung Cancer Progression in Mice
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Metadata
- Authors
- Watson, J.
- Venue
- Open Biology
- Publisher
- The Royal Society
- Published
- 2013-01
- Volume
- 3
- Issue
- 1
- Pages
- 120144
- ISSN
- 2046-2441 (ISSN-L)
- OpenAlex
- W1980763538
- Cited by
- 354
- References
- 11
- FWCI
- 25.01
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
