The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Biosynthesis and biology of mammalian GPI-anchored proteins
Open accessAbstract
At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side chains. The entire GPI-AP is anchored to the outer leaflet of the lipid bilayer by insertion of fatty chains of phosphatidylinositol. Because of GPI-dependent membrane anchoring, GPI-APs have some unique characteristics. The most prominent feature of GPI-APs is their association with membrane microdomains or membrane rafts. In the polarized cells such as epithelial cells, many GPI-APs are exclusively expressed in the apical surfaces, whereas some GPI-APs are preferentially expressed in the basolateral surfaces. Several GPI-APs act as transcytotic transporters carrying their ligands from one compartment to another. Some GPI-APs are shed from the membrane after cleavage within the GPI by a GPI-specific phospholipase or a glycosidase. In this review, I will summarize the current understanding of GPI-AP biosynthesis in mammalian cells and discuss examples of GPI-dependent functions of mammalian GPI-APs.
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Cites
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Zhang, J., Humphreys, I. R., Pei, J., Kim, J., Choi, C., Yuan, R., Durham, J., Liu, S., Choi, H.-J., Baek, M., et al. (2025) · Science · doi:10.1126/science.adt1630 · Cited by 87
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Fossa, S. L., Anton, B. P., Kneller, D. W., Petralia, L. M. C., Ganatra, M. B., Boisvert, M. L., Vainauskas, S., Chan, S.-H., Hokke, C. H., Foster, J. M., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105437 · Cited by 7
Metadata
- Authors
- Kinoshita, T.
- Venue
- Open Biology
- Publisher
- The Royal Society
- Published
- 2020-03
- Volume
- 10
- Issue
- 3
- Pages
- 190290-190290
- ISSN
- 2046-2441 (ISSN-L)
- OpenAlex
- W3012101911
- Cited by
- 341
- References
- 157
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- gold
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