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Cited by 522

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The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis

Miyata, Toshio, Takeda, Junji, Iida, Yoshiyasu, Yamada, Norio, Inoue, Norimitsu, Takahashi, Minoru, Maeda, Kenji, Kitani, Teruo, Kinoshita, Taroh·1993·Science
DOI 10.1126/science.7680492
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Abstract

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N -acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

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Metadata

Authors
Miyata, T., Takeda, J., Iida, Y., Yamada, N., Inoue, N., Takahashi, M., Maeda, K., Kitani, T., & Kinoshita, T.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-02-26
Volume
259
Issue
5099
Pages
1318-1320
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7680492
OpenAlex
W2054323447
Cited by
522
References
0
FWCI
10.99
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis. https://app.cochat.ai/papers/10.1126/science.7680492
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Miyata, T., Takeda, J., Iida, Y., Yamada, N., Inoue, N., Takahashi, M., Maeda, K., Kitani, T., & Kinoshita, T. (1993). The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis. Science. https://doi.org/10.1126/science.7680492

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.