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Estimates of quantal content during 'chemical potentiation' of transmitter release
Abstract
The number of quantal transmitter packets (m), released from motor nerve terminals in response to a single stimulus, has been estimated from the ratio of the amplitudes of endplate currents (e. p. c.) to spontaneous miniature endplate currents (m. e. p. c.), in voltage-clamped endplates of the frog. At 6 °C, the average value of m at normal nerve-muscle junctions was about 300. If allowance is made for the temporal dispersion of quantal transmitter release during the e. p. c., this value is increased by about 30 %. After treatment with diaminopyridine or tetraethylammonium, transmitter release in response to a nerve stimulus is greatly enhanced and values of m exceeding 104 are frequently found. Moreover, the duration of the e. p. c. becomes much longer than that of the m. e. p. cs. The number of packets then liberated during the e. p. c. is much larger than the number of 'active zones' of the endplate and may even exceed the total number of vesicles lined up in twin-files adjacent to the presynaptic membrane.
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Cited by
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Structural changes after transmitter release at the frog neuromuscular junction.
Heuser, J. E., & Reese, T. S. (1981) · The Journal of cell biology · doi:10.1083/jcb.88.3.564 · Cited by 469
The Structural Organization of the Readily Releasable Pool of Synaptic Vesicles
Rizzoli, S. O., & Betz, W. J. (2004) · Science · doi:10.1126/science.1094682 · Cited by 337
Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317
Diamond, J. S., & Jahr, C. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90098-5 · Cited by 301
Metadata
- Authors
- Katz, B., & Miledi, R.
- Venue
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Publisher
- The Royal Society
- Published
- 1979-08-31
- Volume
- 205
- Issue
- 1160
- Pages
- 369-378
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2070366880
- Cited by
- 191
- References
- 0
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Katz, B., & Miledi, R. (1979). Estimates of quantal content during 'chemical potentiation' of transmitter release. Proceedings of the Royal Society of London. Series B. Biological Sciences. https://doi.org/10.1098/rspb.1979.0070
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