Structure and function in neuropeptides
Abstract
This report reviews some aspects of the organization of molecular information, structure-activity relations and receptor interactions of three members of a family of neuroactive and hormonal peptides, adrenocorticotrophin (ACTH), alpha-melanotrophin (alpha-MSH) and the enkephalins, as they are presently being investigated in the author's laboratory (in collaboration with H. W. Kosterlitz, D. Schulster and P. W. Schiller). It has been established that ACTH acts on two different steroidogenically responsive receptors in rat adrenocortical cells: one that stimulates steroidogenesis without cyclic AMP synthesis and one that induces cyclic AMP production. This finding is a further example of the pleiotropic action of the opiocortin gene through different mechanisms. Another recent discovery, also related to the organization of ACTH information, reveals an unexpected interaction of ACTH(1-24) with lipid bilayer membranes: the molecule binds to the membranes in a reversible fashion and penetrates them. Parts of the hormonal message are exposed on the side of the membrane opposite to that to which the hormone was added. New 'fat' amino acids like carboranylalanine and adamantylalanine, as well as t-butylglycine, have been used to establish structure-activity relations and the influence of strongly enhanced lipophilicity on the biological activity of the enkephalins. An address/potentiator function of the two C-terminal amino acids is suggested. Tobacco mosaic virus (TMV) has been used as a carrier for covalently attached peptide hormones. Attachment of large numbers of hormone molecules endows these conjugates with the properties of superpotency, superaffinity and prolonged action on the target cell. Some of these properties are illustrated by TMV-enkephalin conjugates.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The most N-terminal region (Ser-Tyr-Ser) has been reported to potentiate the action of the HFRW sequence.
“The most N-terminal region (Ser–Tyr–Ser) has been reported to potentiate the action of the HFRW sequence (46).”
From ACTH Antagonists (2016) · cites this paper as [46]
Cites
Substituent constants for correlation analysis in chemistry and biology
Hansch, C. H., & Leo, A. J. (1979) · Medical Entomology and Zoology · Cited by 2,910 · see citing works
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
Nakanishi, S., Inoue, A., Kita, T., Inoue, A., Nakamura, M., Chang, A. C. Y., Cohen, S. N., & Numa, S. (1979) · Nature · doi:10.1038/278423a0 · Cited by 1,760 · see citing works
ACTH: a short introductory review
Schwyzer, R. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb41843.x · Cited by 394 · see citing works
Self-citationStructure-Activity Relationships of Enkephalin-Like Peptides
Morley, J. S. (1980) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.20.040180.000501 · Cited by 281 · see citing works
Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptor
Schiller, P. W., Lipton, A., Horrobin, D. F., et al. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91149-x · Cited by 133 · see citing works
Henschen, A., Lottspeich, F., Brantl, V., & Teschemacher, H. (1979) · PubMed · Cited by 129 · see citing works
An analysis of the “pleiotropic” effects of a new lethal mutation in the rat ( Mus norvegicus )
Grüneberg, H. (1938) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1938.0017 · Cited by 94 · see citing works
A Simplifying Concept in Tumor Virology: Virus-specific "Pleiotropic Effectors"Preprint
Weil, R., Salomon, C., May, E., et al. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.039.01.050 · Cited by 87 · see citing works
L ‐o‐Carboranylalanine, a Boron Analogue of Phenylalanine
Leukart, O., Caviezel, M., Eberlé, A. N., et al. (1976) · Helvetica Chimica Acta · doi:10.1002/hlca.19760590630 · Cited by 77 · see citing works
Podesta, E. J., Milani, A., Steffen, H., et al. (1979) · Biochemical Journal · doi:10.1042/bj1800355 · Cited by 69 · see citing works
Chemical structure and biological activity in the field of polypeptide hormones
Schwyzer, R. (1963) · Pure and Applied Chemistry · doi:10.1351/pac196306030265 · Cited by 67 · see citing works
Self-citationFischli, W., Leukart, O., & Schwyzer, R. (1977) · Helvetica Chimica Acta · doi:10.1002/hlca.19770600326 · Cited by 50 · see citing works
Self-citationBristow, A. F., Gleed, C., Fauchère, J., et al. (1980) · Biochemical Journal · doi:10.1042/bj1860599 · Cited by 49 · see citing works
BUGBEE, E. P., SIMOND, A. E., & GRIMES, H. M. (1931) · Endocrinology · doi:10.1210/endo-15-1-41 · Cited by 40 · see citing works
Eberlé, A. N., Leukart, O., Schiller, P. W., et al. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80612-1 · Cited by 33 · see citing works
Synthetische Polypeptide mit physiologischer Wirkung
Schwyzer, R. (1963) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bf02259177 · Cited by 32 · see citing works
Self-citationLang, U., Karlaganis, G., Vogel, R., & Schwyzer, R. (1974) · Biochemistry · doi:10.1021/bi00709a024 · Cited by 27 · see citing works
Self-citationKriwaczek, V. M., Eberlé, A. N., Müller, M., et al. (1978) · Helvetica Chimica Acta · doi:10.1002/hlca.19780610405 · Cited by 25 · see citing works
Kim, Q., Thanei, P., Caviezel, M., et al. (1979) · Helvetica Chimica Acta · doi:10.1002/hlca.19790620405 · Cited by 25 · see citing works
SEELIG, S. A., Lindley, B. D., & Sayers, G. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(75)39031-9 · Cited by 25 · see citing works
Schlegel, W., & Schwyzer, R. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11266.x · Cited by 24 · see citing works
Self-citationBodanszky, M., Henes, J. B., Yiotakis, A., et al. (1977) · Journal of Medicinal Chemistry · doi:10.1021/jm00221a019 · Cited by 24 · see citing works
Sayers, G., SEELIG, S. A., Kumar, S., Karlaganis, G., Schwyzer, R., & Fujino, M. (1974) · Experimental Biology and Medicine · doi:10.3181/00379727-145-37772 · Cited by 22 · see citing works
Self-citationLang, U., Fauchère, J., Pelican, G., et al. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80514-5 · Cited by 21 · see citing works
DISTRIBUTION AND DEGRADATION OF TWO TRITIUM-LABELLED CORTICOTROPHIN ANALOGUES IN THE RAT
Bennett, H. P. J., & McMartin, C. (1979) · Journal of Endocrinology · doi:10.1677/joe.0.0820033 · Cited by 16 · see citing works
Ways, D. K., MAHAFFEE, D. D., & Ontjes, D. A. (1979) · Endocrinology · doi:10.1210/endo-104-4-1028 · Cited by 14 · see citing works
Kriwaczek, V. M., Bonnafous, J., Müller, M., et al. (1978) · Helvetica Chimica Acta · doi:10.1002/hlca.19780610406 · Cited by 14 · see citing works
Elliott, D. A., Draper, M. W., & Rizack, M. A. (1977) · Journal of Medicinal Chemistry · doi:10.1021/jm00214a028 · Cited by 13 · see citing works
An alternative to the cAMP second messenger concept
Schwyzer, R. (1974) · Pure and Applied Chemistry · doi:10.1351/pac197437030299 · Cited by 11 · see citing works
Self-citationEberlé, A. N., & Schwyzer, R. (1976) · Springer eBooks · doi:10.1007/978-1-4684-2772-1_20 · Cited by 9 · see citing works
Self-citationStudies on polypeptide receptors : a critical view on the mechanism of ACTH action
Schwyzer, R. (1978) · PubMed · doi:10.5169/seals-308157 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Clark, A. J., Forfar, R., Hussain, M., Jerman, J., McIver, E., Taylor, D., & Chan, L. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00101 · Cited by 49 · see citing works
“The most N-terminal region (Ser–Tyr–Ser) has been reported to potentiate the action of the HFRW sequence (46).”
BackgroundGoverde, H. J. M., & Smals, A. G. H. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)81009-1 · Cited by 14 · see citing works
- Authors
- Schwyzer, R.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Schwyzer, R.
- Venue
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Publisher
- The Royal Society
- Published
- 1980-10-29
- Volume
- 210
- Issue
- 1178
- Pages
- 5-20
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2018317190
- Cited by
- 38
- References
- 31
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2013: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the Royal Society B Biological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- neuropeptides, ACTH, enkephalin, structure-activity relationship, cyclic AMP, adrenocortical cells, membrane binding, lipophilicity, C-terminal amino acids, tobacco mosaic virus, peptide conjugates
- MeSH terms
- Adrenocorticotropic Hormone, Amino Acid Sequence, Binding Sites, Biological Transport, Endorphins, Enkephalins, Lipid Bilayers, Melanocyte-Stimulating Hormones, Peptide Fragments, Receptors, Cell Surface, Solubility, Structure-Activity Relationship, Tobacco Mosaic Virus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
