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Cited by 14Adrenal Hormones and DisordersStress Responses and CortisolNeuropeptides and Animal Physiology

The anomalous effect of some ACTH-fragments missing the amino acid sequence 1-10 on the corticosteroidogenesis in purified isolated rat adrenal cells

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Goverde, H.J.M., Smals, A.G.H.·1984·FEBS Letters
DOI 10.1016/0014-5793(84)81009-1
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Abstract

The corticosteroidogenicity of ACTH-derived peptides was tested in a purified isolated rat adrenal cell system. The activity was related to the activity of standard ACTH (synthetic hACTH; potency fixed at 100). The peptides ACTH NH2 and ACTH showed steroidogenicity at pharmacological doses (potencies: 0.00067 and 0.00032, respectively). None of the peptides tested inhibited or potentiated the ACTH-induced steroidogenesis at low doses (0.5-50 000 pg). The results suggest the presence of a second center within the ACTH molecule capable of inducing steroidogenesis.

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Crossref · 10.1016/0014-5793(84)81009-1

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16 of 16 references verified0 citation errors · 0 not checkable

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  • Goverde and Smals demonstrated some steroidogenesis with ACTH [11-24].

    “Goverde and Smals (53) demonstrated some steroidogenesis with this peptide.”

    From ACTH Antagonists (2016) · cites this paper as [53]

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Authors
Goverde, H. J. M., & Smals, A. G. H.
Affiliations
Radboud University Nijmegen (NL)
Venue
FEBS Letters
Publisher
Wiley
Published
1984-07-23
Volume
173
Issue
1
Pages
23-26
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/0014-5793(84)81009-1
OpenAlex
W1973596394
Cited by
14
References
16
Citations by year
2020: 1 · 2019: 1 · 2016: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6311 d)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
ACTH fragments, corticosteroid synthesis, adrenal cells, steroidogenic activity
MeSH terms
Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Amino Acid Sequence, Animals, Cells, Cultured, Peptide Fragments, Structure-Activity Relationship, Rats

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