The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
On the adaptive significance of stress-induced immunosuppression
Open accessAbstract
We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest an alternative explanation based on the idea that the immune system is tightly regulated by neuroendocrine mechanisms to avoid hyperactivation and ensuing autoimmune responses. We hypothesize that the risk of autoimmune responses increases during heavy physical workload and that the immune system is suppressed to counteract this.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Parasites, Bright Males, and the Immunocompetence Handicap
Folstad, I., & Karter, A. J. (1992) · The American Naturalist · doi:10.1086/285346 · Cited by 2,799
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Exercise and the immune system: a model of the stress response?
Hoffman-Goetz, L., & Pedersen, B. K. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90177-5 · Cited by 481
Glucocorticoids and stress: permissive and suppressive actions
MUNCK, A., & NÁRAY‐FEJES‐TÓTH, A. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39221.x · Cited by 209
KAPCALA, L. P., CHAUTARD, T., & ESKAY, R. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44699.x · Cited by 103
Cited by
Variation in immune defence as a question of evolutionary ecology
Schmid-Hempel, P. (2003) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2002.2265 · Cited by 722
Martin, L. B., Scheuerlein, A., & Wikelski, M. (2003) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2002.2185 · Cited by 513
Testosterone-mediated immune functions and male life histories
Muehlenbein, M. P., & Bribiescas, R. G. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20419 · Cited by 448
Hanssen, S. A., Hasselquist, D., Folstad, I., & Erikstad, K. E. (2005) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2005.3057 · Cited by 339
Self-citationEngler, H., Bailey, M. T., Engler, A., & Sheridan, J. F. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.11.011 · Cited by 209
Metadata
- Authors
- Råberg, L., Grahn, M., Hasselquist, D., & Svensson, E.
- Venue
- Proceedings of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 1998-09-07
- Volume
- 265
- Issue
- 1406
- Pages
- 1637-1641
- ISSN
- 0080-4649 (ISSN-L)
- 0962-8452
- 1471-2954
- OpenAlex
- W2051558840
- Cited by
- 467
- References
- 8
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: On the adaptive significance of stress-induced immunosuppression. https://app.cochat.ai/papers/10.1098/rspb.1998.0482
- The paper
- Råberg, L., Grahn, M., Hasselquist, D., & Svensson, E. (1998). On the adaptive significance of stress-induced immunosuppression. Proceedings of the Royal Society of London. Series B: Biological Sciences. https://doi.org/10.1098/rspb.1998.0482
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
