The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Reduced neural sensitivity to social stimuli in infants at risk for autism
Open accessAbstract
In the hope of discovering early markers of autism, attention has recently turned to the study of infants at risk owing to being the younger siblings of children with autism. Because the condition is highly heritable, later-born siblings of diagnosed children are at substantially higher risk for developing autism or the broader autism phenotype than the general population. Currently, there are no strong predictors of autism in early infancy and diagnosis is not reliable until around 3 years of age. Because indicators of brain functioning may be sensitive predictors, and atypical social interactions are characteristic of the syndrome, we examined whether temporal lobe specialization for processing visual and auditory social stimuli during infancy differs in infants at risk. In a functional near-infrared spectroscopy study, infants aged 4–6 months at risk for autism showed less selective neural responses to social stimuli (auditory and visual) than low-risk controls. These group differences could not be attributed to overall levels of attention, developmental stage or chronological age. Our results provide the first demonstration of specific differences in localizable brain function within the first 6 months of life in a group of infants at risk for autism. Further, these differences closely resemble known patterns of neural atypicality in children and adults with autism. Future work will determine whether these differences in infant neural responses to social stimuli predict either later autism or the broader autism phenotype frequently seen in unaffected family members.
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Cites
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Cognitive neuroscience of human social behaviour
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Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
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Brain structural abnormalities in young children with autism spectrum disorder
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Cited by
Developmental pathways to autism: A review of prospective studies of infants at risk
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Self-citationRogers, S. J., Vismara, L., Wagner, A. L., McCormick, C., Young, G., & Ozonoff, S. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2202-y · Cited by 328
Brain adaptation and alternative developmental trajectories
Johnson, M. H., Jones, E. J. H., & Gliga, T. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000073 · Cited by 213
Self-citationFrom early markers to neuro-developmental mechanisms of autism
Gliga, T., Jones, E. J. H., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Developmental Review · doi:10.1016/j.dr.2014.05.003 · Cited by 150
Self-citationAutism and the Social Brain: The First-Year Puzzle
Elsabbagh, M., & Johnson, M. H. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.019 · Cited by 136
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Metadata
- Authors
- Lloyd-Fox, S., Blasi, A., Elwell, C. E., Charman, T., Murphy, D., & Johnson, M. H.
- Venue
- Proceedings of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2013-05-07
- Volume
- 280
- Issue
- 1758
- Pages
- 20123026
- ISSN
- 0080-4649 (ISSN-L)
- 0962-8452
- 1471-2954
- OpenAlex
- W2118779648
- Cited by
- 181
- References
- 26
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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