The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Applications of terahertz spectroscopy to pharmaceutical sciences
Abstract
The application of terahertz pulsed spectroscopy within the US Food and Drug Administration's (FDA's) recent process analytical technology (PAT) initiative is considered. As a case study the potency levels in paracetamol (4-acetamidophenol) and aspirin (acetylsalicylic acid) test tablets have been recovered from the terahertz absorption spectra using a multivariate partial-least-squares (PLS) calibration model. Root-mean-square errors of cross-validation (RMSECVs) of 2.85% and 3.90% were obtained for paracetamol and aspirin, respectively. Information about other excipients can also be obtained; for example, using the strong lactose absorption lines in the tablets, RMSECVs of 3.65% and 4.30% could be recovered from the paracetamol and aspirin samples, respectively. As active ingredients may also change their solid-state form during formulation processing or storage and as this can adversely affect the final dosage performance, monitoring of pharmaceutical ingredients is essential for a 'right-first-time' philosophy within the industry. Terahertz pulse spectroscopy is a high-throughput technique with many areas of potential exploitation in the pharmaceutical industry; these issues are discussed in this paper.
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“Still, the results obtained match the data available in the literature [40], [41].”
From A New Metric for the Comparison of Permittivity Models in Terahertz Time-Domain Spectroscopy (2024) · cites this paper as [41]
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Cites
60-fsec pulse generation from a self-mode-locked Ti:sapphire laser
Spence, D. E., Kean, P. N., & Sibbett, W. (1991) · Optics Letters · doi:10.1364/ol.16.000042 · Cited by 1,558
Subpicosecond photoconducting dipole antennas
Smith, P. R., Auston, D. H., & Nuss, M. C. (1988) · IEEE Journal of Quantum Electronics · doi:10.1109/3.121 · Cited by 805
Chemometrics: Statistics and Computer Application in Analytical Chemistry
(2001) · Microchemical Journal · doi:10.1016/s0026-265x(00)00156-9 · Cited by 753
Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy
Fischer, B. M., Walther, M., & Jepsen, P. U. (2002) · Physics in Medicine and Biology · doi:10.1088/0031-9155/47/21/319 · Cited by 589
Terahertz Pulse Imaging of ex vivo Basal Cell Carcinoma
Woodward, R. M., Wallace, V. P., Pye, R. J., Cole, B. E., Arnone, D. D., Linfield, E. H., & Pepper, M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12013.x · Cited by 434
Free-space electro-optics sampling of mid-infrared pulses
Wu, Q. Y. S., & Zhang, X.-C. (1997) · Applied Physics Letters · doi:10.1063/1.119873 · Cited by 396
Noncovalent intermolecular forces in polycrystalline and amorphous saccharides in the far infrared
Walther, M., Fischer, B. M., & Uhd Jepsen, P. (2003) · Chemical Physics · doi:10.1016/s0301-0104(03)00031-4 · Cited by 369
Walther, M., Płochocka, P., Fischer, B., Helm, H., & Jepsen, P. U. (2002) · Biopolymers · doi:10.1002/bip.10106 · Cited by 326
Taday, P. F., Bradley, I. V., Arnone, D. D., & Pepper, M. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10358 · Cited by 316
Self-citation(2014) · Chemistry International · doi:10.1515/ci.2014.36.4.33a · Cited by 217
Research works printed but not linked: 1
- O'Neill S. 2003 Implementing Process Analytical Technology Conf. 3-6 June 2003 Brussels.
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Terahertz spectroscopy and imaging - Modern techniques and applications
Jepsen, P. U., Cooke, D. G., & Koch, M. (2011) · Laser & Photonics Reviews · doi:10.1002/lpor.201000011 · Cited by 2,091
Terahertz spectroscopy of explosives and drugs
Davies, A. G., Burnett, A. D., Fan, W., Linfield, E. H., & Cunningham, J. E. (2008) · Materials Today · doi:10.1016/s1369-7021(08)70016-6 · Cited by 589
Terahertz Frequency Sensing and Imaging: A Time of Reckoning Future Applications?
WOOLARD, D. L., Brown, R., Pepper, M., & Kemp, M. C. (2005) · Proceedings of the IEEE · doi:10.1109/jproc.2005.853539 · Cited by 447
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
Simon, L. L., Pataki, H., Marosi, G., Meemken, F., Hungerbühler, K., Baiker, A., Tummala, S., Glennon, B., Kuentz, M., Steele, G., et al. (2015) · Organic Process Research & Development · doi:10.1021/op500261y · Cited by 445
Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting - a review
Zeitler, J. A., Taday, P. F., Newnham, D. A., Pepper, M., Gordon, K. C., & Rades, T. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.2.0008 · Cited by 409
Self-citation
Metadata
- Authors
- Taday, P. F.
- Affiliations
- TeraView (United Kingdom) (GB)
- Corresponding author
- Taday, Philip F.
- ORCID
- Taday, Philip F.
- Venue
- Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
- Publisher
- The Royal Society
- Published
- 2003-12-19
- Volume
- 362
- Issue
- 1815
- Pages
- 351-364
- ISSN
- 1364-503X (ISSN-L)
- 1471-2962
- OpenAlex
- W2167697843
- Cited by
- 239
- References
- 17
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 13
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences (publishedVersion)
- PubMed (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Keywords
- terahertz spectroscopy, tablets, paracetamol, aspirin, process analytical technology, partial least squares calibration, terahertz absorption spectra, pharmaceutical quality control, high-throughput analysis
- MeSH terms
- Acetaminophen, Algorithms, Aspirin, Chemistry, Pharmaceutical, Drug Contamination, Infrared Rays, Microwaves, Quality Assurance, Health Care, Sensitivity and Specificity, Spectrophotometry, Infrared, Reproducibility of Results
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