Cited by 239Terahertz technology and applicationsSpectroscopy and Chemometric AnalysesAnalytical Methods in Pharmaceuticals

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Applications of terahertz spectroscopy to pharmaceutical sciences

Taday, Philip F.·2004·Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences

DOI 10.1098/rsta.2003.1321

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Abstract

The application of terahertz pulsed spectroscopy within the US Food and Drug Administration's (FDA's) recent process analytical technology (PAT) initiative is considered. As a case study the potency levels in paracetamol (4-acetamidophenol) and aspirin (acetylsalicylic acid) test tablets have been recovered from the terahertz absorption spectra using a multivariate partial-least-squares (PLS) calibration model. Root-mean-square errors of cross-validation (RMSECVs) of 2.85% and 3.90% were obtained for paracetamol and aspirin, respectively. Information about other excipients can also be obtained; for example, using the strong lactose absorption lines in the tablets, RMSECVs of 3.65% and 4.30% could be recovered from the paracetamol and aspirin samples, respectively. As active ingredients may also change their solid-state form during formulation processing or storage and as this can adversely affect the final dosage performance, monitoring of pharmaceutical ingredients is essential for a 'right-first-time' philosophy within the industry. Terahertz pulse spectroscopy is a high-throughput technique with many areas of potential exploitation in the pharmaceutical industry; these issues are discussed in this paper.

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Authors: Taday, P. F.
Affiliations: TeraView (United Kingdom) (GB)
Corresponding author: Taday, Philip F.
ORCID: Taday, Philip F.
Venue: Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
Publisher: The Royal Society
Published: 2003-12-19
Volume: 362
Issue: 1815
Pages: 351-364
ISSN: 1364-503X (ISSN-L)
1471-2962
DOI: 10.1098/rsta.2003.1321
OpenAlex: W2167697843
Cited by: 239
References: 17
Citations by year: 2026: 6 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 13
FWCI: 7.35
Type: journal article
Language: en
Open access: closed
Locations: Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences (publishedVersion)
PubMed (publishedVersion)
Science and Technology Facilities Council (submittedVersion)
Topics: Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
Keywords: terahertz spectroscopy, tablets, paracetamol, aspirin, process analytical technology, partial least squares calibration, terahertz absorption spectra, pharmaceutical quality control, high-throughput analysis
MeSH terms: Acetaminophen, Algorithms, Aspirin, Chemistry, Pharmaceutical, Drug Contamination, Infrared Rays, Microwaves, Quality Assurance, Health Care, Sensitivity and Specificity, Spectrophotometry, Infrared, Reproducibility of Results

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Applications of terahertz spectroscopy to pharmaceutical sciences

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