The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Structure and mechanism of ATP-binding cassette transporters
Open accessAbstract
ATP-binding cassette (ABC) transporters constitute a large superfamily of integral membrane proteins that includes both importers and exporters. In recent years, several structures of complete ABC transporters have been determined by X-ray crystallography. These structures suggest a mechanism by which binding and hydrolysis of ATP by the cytoplasmic, nucleotide-binding domains control the conformation of the transmembrane domains and therefore which side of the membrane the translocation pathway is exposed to. A basic, conserved two-state mechanism can explain active transport of both ABC importers and ABC exporters, but various questions remain unresolved. In this article, I will review some of the crystal structures and the mechanistic insight gained from them. Future challenges for a better understanding of the mechanism of ABC transporters will be outlined.
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Citations
Cites
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985
Structure of a bacterial multidrug ABC transporter
Dawson, R. J. P., & Locher, K. P. (2006) · Nature · doi:10.1038/nature05155 · Cited by 1,279
Self-citationThe E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
Locher, K. P., Lee, A. T., & Rees, D. C. (2002) · Science · doi:10.1126/science.1071142 · Cited by 1,023
Self-citationStructure and Function of the CFTR Chloride Channel
SHEPPARD, D. N., & WELSH, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,018
The ABC protein turned chloride channel whose failure causes cystic fibrosis
Gadsby, D. C., Vergani, P., & Csanády, L. (2006) · Nature · doi:10.1038/nature04712 · Cited by 703
Structure and mechanism of ABC transporter proteins
Hollenstein, K., Dawson, R. J., & Locher, K. P. (2007) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.07.003 · Cited by 671
Self-citationATP-Binding Cassette Transporters in Bacteria
Davidson, A. L., & Chen, J. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073626 · Cited by 666
The ABC transporter structure and mechanism: perspectives on recent research
Jones, P. M., & George, A. M. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-3336-9 · Cited by 578
Crystal structure of a catalytic intermediate of the maltose transporter
Oldham, M. L., Khare, D., Quiocho, F. A., Davidson, A. L., & Chen, J. (2007) · Nature · doi:10.1038/nature06264 · Cited by 508
Cited by
ABC transporters: the power to change
Rees, D. C., Johnson, E., & Lewinson, O. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2646 · Cited by 1,450
Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Locher, K. P. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3216 · Cited by 804
Self-citationEngaging neuroscience to advance translational research in brain barrier biology
Neuwelt, E. A., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O'Donnell, M. E., Povlishock, J. T., et al. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2995 · Cited by 579
Stieger, B. (2011) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-14541-4_5 · Cited by 269
Recent insights into iron import by bacteria
Braun, V., & Hantke, K. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.01.005 · Cited by 264
Metadata
- Authors
- Locher, K. P.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2008-10-28
- Volume
- 364
- Issue
- 1514
- Pages
- 239-245
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2155590507
- Cited by
- 414
- References
- 34
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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