Cited by 475Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsPsychedelics and Drug Studies

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

Open access

Campos, Alline Cristina, Moreira, Fabricio Araújo, Gomes, Felipe Villela, Del Bel, Elaine Aparecida, Guimarães, Francisco Silveira·2012·Philosophical Transactions of the Royal Society B: Biological Sciences

DOI 10.1098/rstb.2011.0389PMC PMC3481531

Open this paper in CoChat — free account

Abstract

Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ(9)-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis. Although the pharmacological effects of CBD in different biological systems have been extensively investigated by in vitro studies, the mechanisms responsible for its therapeutic potential are still not clear. Here, we review recent in vivo studies indicating that these mechanisms are not unitary but rather depend on the behavioural response being measured. Acute anxiolytic and antidepressant-like effects seem to rely mainly on facilitation of 5-HT1A-mediated neurotransmission in key brain areas related to defensive responses, including the dorsal periaqueductal grey, bed nucleus of the stria terminalis and medial prefrontal cortex. Other effects, such as anti-compulsive, increased extinction and impaired reconsolidation of aversive memories, and facilitation of adult hippocampal neurogenesis could depend on potentiation of anandamide-mediated neurotransmission. Finally, activation of TRPV1 channels may help us to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD. Considering its safety profile and wide range of therapeutic potential, however, further studies are needed to investigate the involvement of other possible mechanisms (e.g. inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca(2+)) increase, etc.), on CBD behavioural effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1098/rstb.2011.0389

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
The orphan receptor GPR55 is a novel cannabinoid receptor
Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N., Leonova, J., Elebring, T., Nilsson, K., Drmota, T., & Greasley, P. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707460 · Cited by 1,568
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551

Flagged first, then by citations

Show all 135 references

Research works printed but not linked: 1

Campos A. C., 2011, Hippocampal proliferative processes are needed for behavioral effects of cannabidiol, Revista de Neurosciências, 19, 81

Sorted by citations

Items 301–400 of 474

Cannabidiol treatment prevents drug reinstatement and the molecular alterations evoked by amphetamine on receptors and enzymes from dopaminergic and endocannabinoid systems in rats
Metz, V. G., da Rosa, J. L. O., Rossato, D. R., Bürger, M. E., & Pase, C. S. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173427 · Cited by 5
Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults
Raddo, M.-E. D., Milenkovic, M., Sivasubramanian, M., Hasbi, A., Bergman, J., Withey, S. L., Madras, B. K., & George, S. R. (2023) · Current Research in Neurobiology · doi:10.1016/j.crneur.2023.100107 · Cited by 5
Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson’s Disease
Хаспеков, Л. Г., & Illarioshkin, S. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158520 · Cited by 5
Therapeutic Effects of Cannabidiol on Methamphetamine Abuse: A Review of Preclinical Study.
Razavi, Y., Keyhanfar, F., Shabani, R., Haghparast, A., & Mehdizadeh, M. (2021) · PubMed Central · doi:10.22037/ijpr.2021.114918.15106 · Cited by 6
Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity
Macêdo-Souza, C., Maisonnette, S. S., Hallak, J. E. C., Crippa, J. A. S., Zuardi, A. W., Landeira-Fernández, J., & Leite‐Panissi, C. R. A. (2023) · Pharmaceuticals · doi:10.3390/ph16071003 · Cited by 5
Unique treatment potential of cannabidiol for the prevention of relapse to drug use
Weiss, F., & González‐Cuevas, G. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0218-2 · Cited by 5
Are cannabidiol (CBD) levels in consumer food products well tested?—A review
Siddiqui, S. A., Fidan, H., Stankov, S., Mehdizadeh, M., Ambartsumov, T. G., Kharazmi, M., Singh, S., & Jafari, S. M. (2023) · Food Frontiers · doi:10.1002/fft2.308 · Cited by 5
LOTUS: Protocol for a double-blind placebo controlled randomized trial of hemp-derived cannabidiol for the treatment of cannabis use disorder
Bidwell, L. C., Martin‐Willett, R., Melendez, S. N., Rosa, L., Giordano, G., Hutchison, K. E., & Bryan, A. D. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308262 · Cited by 4
Investigation of Cannabidiol's Protective Effects on Cadmium‐Induced Toxicity in Mice
Şahin, S., Mortaş, T., Müderrisoğlu, A., & Türksoy, V. A. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14131 · Cited by 4
Cannabidiol Modulating the Expression of Neurotrophin Signaling Pathways in Chronic Exposure to Methamphetamine in Rats During Abstinence Period
Razavi, Y., Najafi, M., Haghparast, A., Keyhanfar, F., Shabani, R., & Mehdizadeh, M. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.3059.1 · Cited by 4
Evidence For Cannabidiol Modulation of Serotonergic Transmission in a Model of Osteoarthritis via in vivo PET Imaging and Behavioral Assessment
Ding, Y., Wang, J., Kumar, V., Ciaccio, J. A., Dakhel, S., Tan, C. S., Kim, J., Lee, S., Katz-Lichtenstein, H., Youss, Z. B., et al. (2022) · International Journal of Innovative Research in Medical Science · doi:10.23958/ijirms/vol07-i06/1418 · Cited by 4
Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy
Miziak, B., & Czuczwar, S. J. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2150164 · Cited by 5
Behavioral observations, heart rate and heart rate variability in horses following oral administration of a cannabidiol containing paste in three escalating doses (part 1/2)
Eichler, F., Ehrle, A., Jensen, K. C., Baudisch, N., Petersen, H., Bäumer, W., Lischer, C. J., & Wiegard, M. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1305868 · Cited by 4
Molecular Findings Guiding the Modulation of the Endocannabinoid System as a Potential Target to Treat Schizophrenia
Zuccoli, G. S., Brandão‐Teles, C., Vieira, G. M., Gomes, F. V., & Crunfli, F. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-97182-3_7 · Cited by 4
Self-citation
Cannabidiol Attenuates In Vivo Leukocyte Recruitment to the Spinal Cord Microvasculature at Peak Disease of Experimental Autoimmune Encephalomyelitis
da Silva, T. V., Bernardes, D., Oliveira‐Lima, O. C., Pinto, B. F., Filho, M. L., Faraco, C. C. F., Juliano, M. A., Arantes, R. M. E., Moreira, F. A., & Tavares, J. C. (2023) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0103 · Cited by 4
Self-citation
Phytocannabinoids: Tetrahydrocannabinol (THC)
Roychoudhury, P., Wang, N. N., & Narouze, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-69186-8_10 · Cited by 4
Looking ahead after 50 years of research on cannabinoids
Mechoulam, R. (2014) · Wiley eBooks · doi:10.1002/9781118451281.ch1 · Cited by 4
Cannabinoids and Extracellular Vesicles as Potential Biomarkers and Therapeutic Targets in Neuropsychiatric Disorders: A Hypothesis-Driven Review
Marques, B. L., Lirio, P. H. C., Vicente, M. A., Unzueta‐Larrinaga, P., Urigüen, L., & Campos, A. C. (2025) · Pharmaceuticals · doi:10.3390/ph18121817 · Cited by 3
Self-citation
Medicinal cannabis plant extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome
Keating, B. A., Han, V. X., Nishida, H., Aryamanesh, N., Marshall, L. L., Gloss, B., Lau, X., Dissanayake, R., Dervish, S., Graham, M. E., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00828 · Cited by 3
Historical perspective on the therapeutic potential of cannabidiol
Guimarães, F. S. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.03.008 · Cited by 4
Self-citation
Cannabinoids: Drug or Medication?
Giron, L., & Befort, K. (2016) · InTech eBooks · doi:10.5772/63172 · Cited by 4
Evaluation of anxiety-like behaviors following ethanol withdrawal in mice: effects of cannabidiol
Coltri, L. P., Bonassoli, V. T., Milani, H., & de Oliveira, R. M. W. (2020) · Acta Scientiarum Health Sciences · doi:10.4025/actascihealthsci.v42i1.53001 · Cited by 3
Cannabis Sativa: uma revisão integrativa dos aspectos legais, toxicológicos e farmacoterapêuticos
Pessoa, D. D. O. C., Lira, I. V., & Siqueira, L. D. P. (2021) · Research Society and Development · doi:10.33448/rsd-v10i15.22408 · Cited by 4
Cannabidiol in the treatment and prevention of Alzheimer’s disease – a comprehensive overview of in vitro and in vivo studies
Drożak, P., Skrobas, U., & Drożak, M. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.09.097 · Cited by 5
Therapeutic Effects of Medicinal Cannabinoids on the Gastrointestinal System in Pediatric Patients: A Systematic Review
Sunil, M., Karimi, P., Leong, R., Zúñiga-Villanueva, G., & Ratcliffe, E. M. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0192 · Cited by 3
Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus
Chaves, Y. C., Raymundi, A. M., Waltrick, A. P. F., Crippa, J. A. S., Stern, C. A. J., da Cunha, J. M., & Zanoveli, J. M. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.13 · Cited by 3
Pros and Cons of Cannabinoids as a Potential Therapeutic Target for Treating Parkinson's Disease
Pattabhiramaiah, M., Mallikarjunaiah, S., & Sarma, B. B. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5652-1.ch009 · Cited by 3
O USO TERAPÊUTICO DO CANABIDIOL (CBD) NO TRATAMENTO DE TRANSTORNOS DE ANSIEDADE E DEPRESSÃO
Carvalho, M. D. S., Mota, A. D. A. R., da Silva, J. B. M. A., & do Nascimento, G. P. V. (2023) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v4i1.4049 · Cited by 3
The Endocannabinoid System: A Dynamic Signalling System at the Crossroads Between Metabolism and Disease
Witkamp, R. F. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-06151-1_9 · Cited by 3
Canabidiol e suas indicações em psiquiatría
Ramírez, J. F. M. (2021) · Revista Digital Palabra (Universidad Pontificia Bolivariana) · doi:10.18566/medupb.v40n1.a09 · Cited by 3
Overview of Medicinal Cannabis
O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_4 · Cited by 3
A Re-Evaluation of Past to Present-Day Use of the Blissful Neuronal Nutraceutical “Cannabis”
Dhanasekaran, M., Nadar, R. M., McDonald, K. L., DeRuiter, J., Pathak, S., Ramesh, S., Vijayarani, R., Gopal, K., Ramapuram, J. B., Dua, K., et al. (2022) · Journal of Food Nutrition and Metabolism · doi:10.31487/j.jfnm.2022.01.02 · Cited by 3
Cannabis: Innovation Opportunities for its Medical Use
Cuentas, G. L. A., Ramírez-Vergara, J., & Charris-Polo, M. (2018) · Recent Patents on Engineering · doi:10.2174/1872212112666181022155150 · Cited by 3
ОСОБЛИВОСТІ СЕЛЕКЦІЇ НОВИХ СОРТІВ КОНОПЕЛЬ ПОСІВНИХ У ТОВ «ІНСТИТУТ ОРГАНІЧНОГО ЗЕМЛЕРОБСТВА»
Пилипченко, А. В., & Пісковий, М. Б. (2020) · Вісник Полтавської державної аграрної академії · doi:10.31210/visnyk2020.01.01 · Cited by 3
Roles of Cannabidiol in Reversing ProteinopathiesPreprint
Dash, R., Ali, M. C., Jahan, I., Munni, Y. A., Mitra, S., Hannan, M. A., Timalsina, B., Oktaviani, D. F., Choi, H. J., & Moon, I. S. (2020) · Preprints.org · doi:10.20944/preprints202005.0340.v1 · Cited by 3
Comparison between Cannabidiol and Fluoxetine effects on chronic neuropathic pain and depression comorbid in rats
Brito, D. T. P., Medeiros, A. C., Leite‐Panissi, C. R. A., Cárnio, E. C., Machado, H. R., Coimbra, N. C., de Freitas, R. L., & de Medeiros, P. S. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01751-w · Cited by 2
Exploring Membrane Cholesterol Binding to the CB1 Receptor: A Computational Perspective
Vanegas, M. J., Gómez, S., Cappelli, C., & Miscione, G. P. (2025) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c08076 · Cited by 3
Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic‐Like Properties and Memory Interactions
Accioly, M., Rosa, K., Soliani, A. G., Cerutti, S. M., & Raminelli, C. (2025) · ChemBioChem · doi:10.1002/cbic.202500438 · Cited by 2
Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis
Thapa, D., Patil, M., Warne, L. N., Carlessi, R., & Falasca, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167913 · Cited by 2
Cannabidiol for the treatment of positive and negative symptoms in schizophrenia spectrum disorders: a systematic review and meta-analysis
Francesco, A. D., Cutrufelli, P., Chiarenza, C., Zambuto, L., Concerto, C., Mineo, L., Petralia, A., Catalfo, M., Rodolico, A., Samara, M. T., et al. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02249-3 · Cited by 3
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
Jaisankar, D., & Jayaprakash, N. (2026) · Journal of Holistic Integrative Pharmacy · doi:10.1016/j.jhip.2026.05.003 · Cited by 2
Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research
Kayser, R. R., Haney, M., & Simpson, H. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.626150 · Cited by 3
Phytocannabinoids: Cannabidiol (CBD)
Roychoudhury, P., Wang, N. N., & Narouze, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-69186-8_11 · Cited by 2
Pharmacological study of a cannabinoid-containing eyedrop formulation in dogs and mice
Stolf, A. M., Lugarini, D., de Oliveira, A., Sereniki, A., Capitelli, C. S., Tanaka, D. H., Ferreira, F. M., Vital, M. A. B. F., & Acco, A. (2015) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2015.04.005 · Cited by 2
Uso dos canabinóides no tratamento de pessoas portadoras de Alzheimer
Bittes, Y. P., Ribeiro, L. B., Anselmo, G. S., Dantas, T. C. L., Ferreira, M. V. R., Neves, W. C., Barbosa, J. D. S. P., & Silva, D. F. (2021) · Revista de Divulgação Científica Sena Aires · doi:10.36239/revisa.v10.nesp2.p887a898 · Cited by 2
Factors Affecting Performance and Recovery in Team Sports: A Multidimensional Perspective
Bian, C. (2022) · Frontiers research topics · doi:10.3389/978-2-88974-922-5 · Cited by 2
Effect of Broad-Spectrum Hemp Extract on Neurobehavioral Activity on the Immobilization Stress-Induced Model in Sprague Dawley Rats
Shanmugasundaram, D., & Roza, J. M. (2023) · The Scientific World JOURNAL · doi:10.1155/2023/3425576 · Cited by 2
Doenças neurodegenerativas e canabinoides: revisão narrativa
Lopes, C. M., de Camargo, R. W., & de Bitencourt, R. M. (2023) · Revista Neurociências · doi:10.34024/rnc.2023.v31.14952 · Cited by 3
Probing molecular pathways: Illuminating the connection between COVID‐19 and Alzheimer's disease through the endocannabinoid system dynamics
Sun, Q., Gao, J., An, R., Wang, M., & Wang, Y. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29590 · Cited by 2
Terapias farmacológicas e não farmacológicas no tratamento da Doença de Alzheimer – Uma Revisão Narrativa da Literatura
Machado, B. D. S. (2021) · Saúde e Desenvolvimento Humano · doi:10.18316/sdh.v9i3.7098 · Cited by 2
Long-Term Treatment for Unspecified Anxiety Disorders with Cannabidiol: A Retrospective Case Series from Real-World Evidence in Colombia
Galvez-Florez, J. F., Guillen-Burgos, H. F., Flórez-Puentes, C. A., Navarro, C. E., & Moreno‐Sanz, G. (2024) · Medical Cannabis and Cannabinoids · doi:10.1159/000539754 · Cited by 2
Repeated Administration of a Full-Spectrum Cannabidiol Product, Not a Cannabidiol Isolate, Reverses the Lipopolysaccharide-Induced Depressive-Like Behavior and Hypolocomotion in a Rat Model of Low-Grade Subchronic Inflammation
Júnior, L. R. D. N., da Silva, T. V., da Silva, L. M., de Andrade, F. M., da Silva, A. R., Meneguzzo, V., Ramos, S. D. S., Lopes, C. M., Saturnino, A. B., Inserra, A., et al. (2024) · Cannabis and Cannabinoid Research · doi:10.1089/can.2024.0086 · Cited by 2
Cannabidiol (CBD) and Colorectal Tumorigenesis: Potential Dual Modulatory Roles via the Serotonergic Pathway
Liu, Z. (2025) · Current Oncology · doi:10.3390/curroncol32070375 · Cited by 2
Medical food development by dietetic management of the endocannabinoid system through dietary sources of β-caryophyllene
Chiruta, V. (2020) · Traditional Medicine and Modern Medicine · doi:10.1142/s2575900020300039 · Cited by 2
Traditional Plant Compounds for the Treatment of Neuropsychiatric Disorders
Din, I., Anwar, M., Rayees, S., & Malik, F. A. (2020) · Springer eBooks · doi:10.1007/978-981-15-1761-7_18 · Cited by 2
The Use of Marijuana Derivatives in Primary Care: An Evidence-Based Approach to Cannabidiol
Fowler, C. (2021) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2021.07.011 · Cited by 2
Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration
Kajero, J. A., Seedat, S., OHAERI, J. U., Akindele, A. J., & Aina, O. O. (2022) · Discover Mental Health · doi:10.1007/s44192-022-00021-2 · Cited by 2
Different Tokes for Different Folks: Use of Cannabis Products Among a Longitudinal Cohort of People with Heroin Dependence
Wilson, J., Mills, K. L., Sunderland, M., Freeman, T. P., Teesson, M., Haber, P., & Marel, C. (2023) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-023-01071-5 · Cited by 2
Role of hippocampal and prefrontal cortical cholinergic transmission in combination therapy valproate and cannabidiol in memory consolidation in rats: involvement of CREB- BDNF signaling pathways
Fatahi, N., Jafari‐Sabet, M., Vahabzadeh, G., & Komaki‬, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02941-4 · Cited by 2
Topical Cannabidiol and the Progression Rate of Delayed Onset Muscle Soreness.
Alpy, A., Yusuff, G., Simpson, T., Petrizzo, J., Aquino, M., Otto, R. M., & Wygand, J. W. (2023) · PubMed Central · doi:10.70252/kagh6991 · Cited by 2
Medicinal Applications of Cannabidiol from the Genus Cannabis L.
Bag, D., Tabassum, A., Arora, N., Verma, P. K., & Sawant, S. D. (2020) · Springer eBooks · doi:10.1007/978-981-15-5917-4_10 · Cited by 2
Prospective Analysis of Cannabidiol's Effectiveness in Post-Exercise Recovery: An integrative Systematic Review and Research AgendaPreprint
Villalobos-González, C. E., Gómez‐Carmona, C. D., Sánchez‐Ureña, B., Azofeifa-Mora, C., & Rojas‐Valverde, D. (2024) · Preprints.org · doi:10.20944/preprints202405.0517.v1 · Cited by 1
O uso do canabidiol como medicamento no Brasil para tratar doenças crônicas
Morais, C. E. C., Silva, E. P., & Lima, R. S. (2021) · Pubsaúde · doi:10.31533/pubsaude5.a087 · Cited by 1
The Potential Role of Herbal Plants in the Management of Depression: Pre-Clinical and Clinical Evidence
Pannu, A. S., Goyal, R. K., & Sharma, K. (2024) · Current Nutraceuticals · doi:10.2174/0126659786306271240905054531 · Cited by 1
Cannabidiol Pretreatment Reduces Status Epilepticus and Glutamate Uptake Induced by Kainic Acid in Adult Zebrafish
Pickler, K. D. P., de Farias, A. C. S., Lodetti, G., Bernardo, H. T., Baldin, S. L., Dondossola, E. R., Hallak, J. E. C., Crippa, J. A. S., Cararo, J. H., Budni, J., et al. (2025) · Cannabis and Cannabinoid Research · doi:10.1089/can.2024.0189 · Cited by 1
Chronic cannabidiol treatment effects on contextual fear and neuropathic pain in Carioca rats high and low conditioned freezing
Macêdo-Souza, C., Tiballi, A. A. F., Maisonnette, S. S., Rosseti, F. P., Catalão, C. H. R., Hallak, J. E. C., Crippa, J. A. S., Zuardi, A. W., Landeira-Fernández, J., & Leite‐Panissi, C. R. A. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115855 · Cited by 1
Dose- and tissue-dependent effects of cannabidiol on antioxidant status in developing chicken embryos
Muchacka, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-31097-9 · Cited by 1
Unraveling Cannabidiol's Dual Modulatory Role in Schizophrenia: Network Pharmacology and In Vivo Validation of Neuroinflammatory and Behavioral Modulation
Wei, Y., Liu, X., Lin, S., Jia, Z., Liu, L., Wang, B., Liao, L., & Mei, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05608-8 · Cited by 1
The effects of cannabidiol (CBD) in transport water on the behaviour of ornamental fishes
Jones, M. E., Alexander, M. E., Vanderzwalmen, M., Snellgrove, D., Talbot, M., Smith, P., Henriquez, F. L., McLellan, I. S., & Sloman, K. A. (2025) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2025.106897 · Cited by 1
An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol
Costa, G. P. A., Sofuoglu, M., Compton, P. A., Ranganathan, M., Pittman, B. P., & Aquino, J. P. D. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02443-w · Cited by 1
Cannabidiol and epilepsy: therapeutic, mechanistic and clinical significance
Gupta, N., Maan, P., Shrivastava, J., & Ansari, M. H. R. (2026) · Seizure · doi:10.1016/j.seizure.2026.06.014 · Cited by 2
Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling
Acunha, R. M., Domingues, B. R. R., Barros, N., Medeiros, P., Hallak, J. E. C., Coimbra, N. C., Maione, S., & de Freitas, R. L. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07116-6 · Cited by 1
Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent Increased Seizure Susceptibility Following Lithium-Pilocarpine-Induced Status Epilepticus
Gómez, C. T., Fernandez, F., Jara, A., Borda, N., Moscovicz, F., Huamán, Y. Y., Robles, R. J. C., Pacheco‐Otálora, L. F., Lazarowski, A., & Auzmendi, J. (2026) · Brain Sciences · doi:10.3390/brainsci16080851 · Cited by 1
The Ecology of Wild Cannabis sativa
Small, E. (2016) · CRC Press eBooks · doi:10.1201/9781315367583-12 · Cited by 1
Drogen- und Medikamentenabhängigkeit
Majić, T., Mick, I., Kienast, T., Heinz, A., & Soyka, M. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_62-1 · Cited by 1
Cannabis Chemistry: Cannabinoids in Cannabis, Humans, and Other Species
Small, E. (2016) · CRC Press eBooks · doi:10.1201/9781315367583-20 · Cited by 1
Cannabidiol in medicinal usage of stress: Modeling investigations into cocaine
Valverde, O., & García-Fuster, M. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90036-2.00035-1 · Cited by 1
Cannabidiol for the Treatment of Pediatric Epilepsy
Daniel, J. (2023) · Pediatric Annals · doi:10.3928/19382359-20230829-04 · Cited by 1
Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection
Neyestanaki, M. H. K., Gholizadeh, O., Hosseini, F., Akbarzadeh, S., Yasamineh, S., Afkhami, H., & Sedighi, S. (2024) · VirusDisease · doi:10.1007/s13337-024-00871-0 · Cited by 1
Cannabis Use and First-Episode Psychosis Patients (FEP)
González–Ortega, I., Martínez‐Cengotitabengoa, M., & González-Pinto, A. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00030-2 · Cited by 1
Cannabidiol as a Potential Novel Therapeutic Agent for Psychotic Disorders
Deiana, S., & Zamberletti, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804791-0.00014-8 · Cited by 1
SYSTEMIC CANNABIDIOL DOES NOT REDUCE COMPOUND 48/80-INDUCED ITCHING BEHAVIOR IN MICE
Demirel, H., Baksın, E., Özgür, E. Ö., Topuz, R. D., & Ulugöl, A. (2019) · TURKISH MEDICAL STUDENT JOURNAL · doi:10.4274/tmsj.galenos.2019.06.01.02 · Cited by 1
Characteristics of Dispensary Patients that Limit Alcohol after Initiating Cannabis
Hayat, A., & Piper, B. J. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1694199 · Cited by 1
Exploring the Role of Cannabidiol-Monoterpene Formulations in Modulating Anxiety Symptoms
Leu, R. K. L. (2020) · Scholarship@Western (Western University) · Cited by 1
Classification and Analysis of Personal and Commercial CBD Tweets
Turner, J., Kantardzic, M. M., & Vickers‐Smith, R. (2021) · Communications in computer and information science · doi:10.1007/978-3-030-72805-2_10 · Cited by 1
Anxiety
O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_5 · Cited by 1
Cannabinoids and the brain: New hopes for new therapies
Fernández‐Ruíz, J., Hernández, M., & García‐Movellán, Y. (2014) · Wiley eBooks · doi:10.1002/9781118451281.ch6 · Cited by 1
Efeitos do canabidiol no comportamento agressivo induzido por isolamento social em camundongos
dos Santos, A. H. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2017.tde-20072016-151736 · Cited by 1
Cannabidiol pretreatment attenuates locomotor alterations and cytokine production in an autoimmune hepatitis modelPreprint
Mesiakaris, K., Atsopardi, Κ., Margarity, M., & Poulas, K. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.19.440455 · Cited by 1
I Seven International Medical and Nursing Congress
Coelho, P., Rodrigues, F., & Gouveia, A. (2022) · doi:10.56238/sevenmedicalnursing2022 · Cited by 1
Pharmacological actions and associated therapeutic levels of phytocannabinoids Addendum 2021
Arnold, J. C., Allsop, D., Lintzeris, N., & McGregor, I. S. (2016) · doi:10.57022/ovds2305 · Cited by 1
Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der
Bonn, R. F.-W.-U. (2012)
Comparing cannabis control: convergence and divergence in England & Wales and the Netherlands
Brewster, D. (2015) · The Asian Conference on the Social Sciences 2016 - Official Conference Proceedings
Tratamento repetido com canabidiol atenua alterações comportamentais e moleculares em um modelo de esquizofrenia baseado no antagonismo dos receptores NMDA
Gomes, F. V. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2016.tde-05012016-224242
Self-citation
Le cannabis thérapeutique, application à la maladie de Parkinson et essai de mise en forme galénique
Demontoux, J. (2016) · HAL
O Sistema Endocanabinóide - uma perspetiva terapêutica The Endocannabinoid system - a therapeutic perspective
Almada, M., Soares, A. L. P. P. D. P., & Correia‐da‐Silva, G. (2013)
Cannabis Use in Bipolar Disorder
Lagerberg, T. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00049-1
Comparação dos efeitos farmacológicos do canabidiol e seu análogo sintético HU-474
da Silva, N. R. (2017) · doi:10.11606/d.17.2017.tde-20072016-163333
Interviewing and selecting staff: a team approach to interviewing.
Bowden, M., & Carbiener, A. O. (1978) · PubMed
Análise de fatores inflamatórios na discinesia induzida por L-DOPA em modelo de camundongos: caracterização da enzima ciclooxigenase-2
Pereira, M. D. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-24042018-181827

Authors: Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S.
Affiliations: Universidade Federal de Minas Gerais (BR)
Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Avenue Antonio Carlos 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Universidade de São Paulo (BR)
Faculty of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Stomatology, University of São Paulo, Avenue Café s/n, 14040-904, Ribeirão Preto, São Paulo, Brazil
ORCID: Campos, Alline Cristina
Guimarães, Francisco Silveira
Venue: Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher: The Royal Society
Published: 2012-12-05
Volume: 367
Issue: 1607
Pages: 3364-3378
ISSN: 0962-8436 (ISSN-L)
1471-2970
DOI: 10.1098/rstb.2011.0389
PMC: PMC3481531
OpenAlex: W2108265345
Cited by: 475
References: 135
Citations by year: 2026: 21 · 2025: 27 · 2024: 42 · 2023: 39 · 2022: 53 · 2021: 51 · 2020: 50 · 2019: 39 · 2018: 36 · 2017: 35 · 2016: 33 · 2015: 24 · 2014: 15 · 2013: 6 · 2012: 2
FWCI: 1.72
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Locations: Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabidiol, phytocannabinoids, anxiety, depression, psychosis, anxiolytic effects, antidepressant-like effects, 5-HT1A receptor, bed nucleus of the stria terminalis, medial prefrontal cortex, anandamide, TRPV1 channel, antipsychotic effects, bell-shaped dose-response, extinction, memory reconsolidation, adult hippocampal neurogenesis, CB1 receptor antagonism, CB2 receptor, GPR55, PPARγ
MeSH terms: Animals, Antidepressive Agents, Anxiety Disorders, Arachidonic Acids, Cannabidiol, Clinical Trials as Topic, Depression, Dose-Response Relationship, Drug, Humans, Phytotherapy, Synaptic Transmission, Psychotic Disorders, Anti-Anxiety Agents, Receptor, Cannabinoid, CB1, Receptor, Serotonin, 5-HT1A, TRPV Cation Channels, Polyunsaturated Alkamides, Neurogenesis, Endocannabinoids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks