Cited by 306Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsPsychedelics and Drug Studies

Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

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García-Gutiérrez, María S., Navarrete, Francisco, Gasparyan, Ani, Austrich-Olivares, Amaya, Sala, Francisco, Manzanares, Jorge·2020·Biomolecules

Abstract

The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric disorders due to the relative lack of efficacy of the current treatments. Numerous studies have been carried out using the main phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD displays an interesting pharmacological profile without the potential for becoming a drug of abuse, unlike THC. In this review, we focused on the anxiolytic, antidepressant, and antipsychotic effects of CBD found in animal and human studies. In rodents, results suggest that the effects of CBD depend on the dose, the strain, the administration time course (acute vs. chronic), and the route of administration. In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB1r and CB2r), 5-HT1A receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile. These promising results support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders.

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  1. [2]Whiteford H. Ferrari A.J. Degenhardt L. Feigin V. Vos T. Chapter 2 Global burden of mental, neurological and substance use disorder: An analysis from the global burden of disease study 2010 Mental, Neurological, and Substance Use Disorders: Disease Control Priorities 3rd ed. Patel V. Laxminarayan R. Medina-Mora M.L. Dua T. Chisholm D. The International Bank for Reconstruction and Development Washington, DC, USA 2016 Volume 4 27227244
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Authors
García-Gutiérrez, M. S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J.
Affiliations
  • Neurosciences Institute, University Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Manzanares, Jorge
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-11-19
Volume
10
Issue
11
Pages
1575
ISSN
2218-273X (ISSN-L)
OpenAlex
W3101299715
Cited by
306
References
213
Citations by year
2026: 24 · 2025: 79 · 2024: 62 · 2023: 66 · 2022: 46 · 2021: 29
FWCI
4.62
Type
journal article
Language
en
Open access
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords
cannabidiol, anxiety, depression, psychosis, anxiolytic effects, antidepressant effects, antipsychotic effects, tetrahydrocannabinol, phytocannabinoids, cannabinoid receptors, CB1 receptor, CB2 receptor, 5-HT1A receptor, neurogenesis, dose-dependent effects, route of administration, clinical trials, risk-benefit profile
MeSH terms
Animals, Anxiety, Cannabidiol, Depression, Dose-Response Relationship, Drug, Drug Administration Routes, Humans, Psychotic Disorders, Treatment Outcome

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